Allan L. Lorincz

Trigerninal trophic syndrome: A case and review

A 26-year-old woman developed a well-circumscribed, bleeding ulcer at the right nasolabial area 28 months after the recurrence of a posterior fossa meningioma. To our knowledge, this is the first reported case of trigeminal trophic syndrome following an intracranial meningioma. Clinical data from sixty-three cases of trigeminal trophic syndrome in the English literature are reviewed, and etiologic factors are discussed.

Unilateral linear nevoidal syringoma

We here report the unusual occurrence of syringoma in a unilateral linear nevoid distribution in a 32-year-old woman. The papules were located on the right side of the chest and right arm. These lesions need to be distinguished from other linear papular eruptions.

Eruptive nevocytic nevi following erythema multiforme

A patient with erythema multiforme developed many nevocytic nevi, including a large cluster of such lesions at the sites of healed blisters. The development of eruptive nevocytic nevi in this pattern suggests that cutaneous injury plays a role in their pathogenesis.

Cutaneous manifestations of angioimmunoblastic lymphadenopathy

Angioimmunoblastic lymphadenopathy (AIL) is an uncommon immunoproliferative disorder with a presentation similar to malignant lymphoma but with a benign histopathologic picture. We report a case of a 49-year-old woman with AIL who manifested a pruritic maculopapular eruption as her presenting complaint and whose disease pursued an aggressive clinical course. Forty-four percent of patients with AIL experience a nonspecific dermatitis that in general is maculopapular and precedes other clinical symptoms by at least several weeks. AIL should be included in the differential diagnosis of any maculopapular eruption of unknown etiology accompanied by lymphadenopathy.

Dacarbazine-induced photosensitivity reaction

Dacarbazine (DTIC-Dome) is a widely used chemotherapeutic agent employed in the therapy of malignant melanoma. In this communication, we present two patients who developed photosensitivity skin reactions immediately after its administration. Physicians using dacarbazine should be aware of this side effect and should instruct patients to avoid solar exposure following infusions of this drug.

Genital herpes simplex—concepts and treatment

Genital herpes simplex is an increasingly common venereal disease caused by either herpes simplex virus type 1 or 2. The disease can be manifested in a primary and/or recurrent form, the clinical features and complications of which are reviewed. Potential problems include psychosocial difficulties, neonatal herpes simplex infections, and the possibility of an oncogenic role in cervical cancer. Diagnostic modalities, prophylactic measures, and management technics are discussed.

Pigmentary changes in Seckel’s syndrome

Seckels syndrome consists of multiple congenital anomalies, including bird-headed dwarfism, mental deficiency, and skeletal and ophthalmic defects. We report a patient with this syndrome who demonstrated pigmentary changes, including streaks of brown pigmentation on the neck, groin, and axillae. Histologic examination revealed pigment incontinence.

A Case of Primary Cutaneous Histoplasmosis in a Patient with Diabetes and Multi-Infarct Dementia

We report a case of primary cutaneous histoplasmosis in a fifty‐year‐old African‐American woman with diabetes and multi‐infarct dementia. The patient developed fever and crusted, nodulo‐ulcerative lesions of the skin after accidental superficial trauma to the forehead. The biopsy revealed suppurative granulomatous inflammation with intracellular and extracellular yeast‐like cells with associated clear halo measuring 3–4 μm in size. Systemic involvement was not found. The lesions cleared after treatment with itraconazole 200 mg twice a day for 3 weeks. The medication was continued for a total period of 3 months, with no signs of recurrence after one‐year of follow‐up.

Late onset chronic mucocutaneous candidiasis with lymphoma and specific serum inhibitory factor.

A patient with late onset chronic mucocutaneous candidiasis developed lymphocytic lymphoma. A specific inhibitor of in vitro lymphoproliferative responses to candidal antigen was detected in her serum which persisted following clinical remission of candidiasis after combined amphotericin‐B and 5‐Fluorocystosine therapy. It is unclear whether the combined therapy was exclusively anticandidal, nonspecific immunostimulant or cytotoxic affecting the underlying incipient lymphoma.

Pheomycotic cyst in an immunosuppressed host

Abstract A case of pheomycotic cyst due to Exophiala jeanselmei is reported in a patient having chronic lymphocytic leukemia and systemic lupus erythematosus. Isolation and identification of the organism causing pheomycotic cyst is important in terms of prognosis and treatment of this condition.