Althea D. Kessler

Use of a quadruple sulfonamide mixture in acutebacterial infections of infancy and childhood

Summary A mixture containing four derivativesof sulfanilamide, namely, sulfadiazine, Sulfapyrazine, sulfamerazine, and Sulfamethazine, was employed in the treatment of common acute bacterial infections in children. The drug was administered to twenty-one patients in dosage of 0.1 Gm. per kilogram of body weight as the initial dose, followed by 0.025 Gm. per kilogram of body weight every six hours. The clinical and laboratory response to the drug was satisfactory and there were no toxic manifestations or untoward reactions noted.