Amanda Katarinny Goes Gonzaga

Importance of GLUT1 in differential diagnosis of vascular anomalies

Vascular anomalies (VAs) include a group of distinct lesions, such as vascular system congenital malformations, as well as benign and malignant vascular tumors. These lesions may present similar clinical and histopathological features, leading to mistaken diagnoses and incorrect treatment choices. It is important that professionals responsible for monitoring the development of VAs conduct precise investigations and use the appropriate terminology. The human glucose transporter protein isoform 1 (GLUT1) has been proposed as a tool to aid in differential diagnosis between different VAs, given that it is a sensitive and specific marker for identification of infantile hemangiomas (HIs) in any organ. This article presents a review of the literature on this protein as an effective tool for identification and possible differential diagnosis between several VAs.

Ocorrência de Injúrias Orofaciais em Praticantes de Esportes de Luta

Resumen pt: Objetivo: Analisar a ocorrencia de lesoes orofaciais em praticantes de esportes de luta. Metodo: Realizou-se um estudo transversal, descritivo-analitico,...

Subgemmal neurogenous plaque of the tongue: a report of three cases

Subgemmal neurogenous plaque (SNP) is a biphasic neural structure associated with the taste buds. Clinically, SNP usually presents as an asymptomatic, normally colored, papule located in the posterior lateral border of the tongue. Accurate diagnosis is based only on histopathological examination, which shows a superficial neurofibroma-like pattern and a neuroma-like in the deep zone. Appropriate recognition of clinical and morphological aspects of SNPs can avoid their misdiagnosis as neural neoplasms. We report three cases of SNP with detailed clinical, histopathological, and immunohistochemical features.

Temporomandibular joint disk adhesion: evidence from magnetic resonance images

This case report has the aim to present an adhesion of the temporomadibular disc to the articular eminence, diagnosed on magnetic resonance imaging images. A 37-year-old female patient with TMJ (temporomandibular joint) disk adhesion on the left side and complaining of bilateral otalgia over the last 2 years is reported in the present article. The patient did not complain of articular pain or clicking, or any other noises of any nature. Clinical observation showed that the patient had restricted jaw opening, with mandibular deviation the left side without correction during mandibular movement. Our diagnostic impression was of partial anterior disk displacement with reduction of the right side disc; and partial anterior disk displacement with reduction and disc disk adhesion with hypo-mobility of the condyle, on the left temporomandibular joint. The peculiarity of this reported case is the fact that besides the bilateral partial anterior disc displacement, there was also found an adhesion of the disc on the left side. In conclusion, the magnetic resonance imaging exam of the temporomandibular joint can be considered an exam of choice for the evaluation of disc positioning and its morphological alterations.

Eagle's Sydrome: Diagnosis and Incidence in a Brazilian Population

288 Objetivo: estabelecer a incidência da síndrome de Eagle (SE) no curso de Odontologia da Universidade de Fortaleza durante o período de três anos. Materiais e métodos: foram analisadas 945 radiografias panorâmicas. A avaliação foi realizada por dois examinadores em ambiente sem iluminação e com a utilização de negatoscópio. Um paquímetro digital foi utilizado para a mensuração dos casos com alongamento do processo estiloide, sendo considerados alongados os casos a partir de 30 mm. Resultados: das 945 radiografias analisadas, notou-se crescimento do processo estiloide superior a 30 mm em 75 panorâmicas (7,9%), sendo 51 (68%) mulheres e 24 (32%) de homens. Em 43 casos (57,3%), o alongamento foi encontrado bilateralmente, em 23 casos (30,7%) foi encontrado apenas no lado esquerdo e em 9 casos (12%) apenas no lado direito. Os 75 pacientes que possuíam o alongamento do osso foram submetidos a um questionário semiestruturado e 11 pacientes relataram sintomatologia dolorosa, com frequência variável de surgimento da dor. Uma detalhada anamnese e um exame físico desses pacientes permitiram o diagnóstico da SE em quatro deles. Conclusão: o trauma na região craniofacial foi o fator etiológico mais evidente nos pacientes diagnosticados com a SE. Os sinais e sintomas inerentes à SE eram semelhantes aos observados nas desordens craniomandibulares, podendo ocasionar falsos diagnósticos e tratamentos equivocados.

Participation of cyclooxygenase-2 in lip carcinogenesis

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Immune response and evasion mechanisms in lip carcinogenesis: an immunohistochemical study

OBJECTIVES Programmed death ligand-1 (PD-L1) and human leukocyte antigen-G (HLA-G) are considered immune checkpoint molecules that inhibit T-cell effectiveness, contributing to tumor immune escape. This study investigated PD-L1, HLA-G, CD8, and granzyme B (GrB) expression at different stages of lip carcinogenesis. DESIGN AND RESULTS Forty cases of lip squamous cell carcinoma (LSCC), 55 actinic cheilitis (AC), and 10 healthy lip mucosa (HLM) were submitted to immunohistochemistry. Semiquantitative (PD-L1, HLA-G), and quantitative (CD8, GrB) analysis were performed. PD-L1 and HLA-G expression in neoplastic cells/keratinocytes and stroma/connective tissue was significantly higher in LSCC and AC, compared to HLM (p<0.05). PD-L1 was not associated with clinicopathological features of the lesions. HLA-G expression by malignant cells was significantly higher in LSCCs with distant metastasis (p = 0.041).CD8+ and GrB+ cell numbers progressively increased from HLMs to LSCC, with AC exhibiting intermediate numbers (p<0.01). Most LSCCs showed coexistence of PD-L1+ and CD8+ cells (72.5%). PD-L1 was directly correlated to CD8+ and GrB+ lymphocytic infiltration in LSCCs (p<0.05). Low cytotoxic immune response was associated with lymph node metastasis in LSCC (p<0.05). CONCLUSIONS PD-L1 and HLA-G-mediated immune evasion mechanisms are likely to occur from early pre-malignant to advanced malignant stages of lip carcinogenesis, which might provide a rationale for therapeutic blockade of these pathways. PD-L1 expression in LSCCs was correlated with the cytotoxic markers, suggesting that PD-L1 may appear as an escape mechanism in response to an active antitumor response.

The effect of different exposure parameters on proximal caries detection using the Kodak 9000 3D CBCT system

Objective The objective of study was to evaluate the diagnostic quality of CBCT images for caries lesions detection using different exposure parameters. Methods Sixty extracted human teeth were selected and scanned using Kodak 9000 3D CBCT system, with the following exposure parameters combinations: 74 kV, 10mA; 74 kV, 12mA; 74 kV, 8 mA; 70 kV, 10 mA; 70kV, 12 mA; 70 kV e 8 mA; 70 kV, 6.3 mA. Two observers evaluated the images for caries presence using CS 3D Imaging Software. Each observer scored the proximal surfaces of each tooth on a 5-point scale. The scores were compared to histological sections used as gold standard. Accuracy for caries lesion detection was assessed for each exposure parameter combination and evaluated by means of ROC curve analysis. Results The mean values for the areas under the ROC curves for each exposure parameter combination varied from 0.35 to 0.60. There was no statistical significant difference among protocols 1, 2, 4, 6 and 7. However, protocols 3 and 5 differed from all protocols. Conclusion Although the highest dose protocol was the most efficient for proximal caries detection, the lowest dose protocol should be chosen based on the ALADA principle. Indexing terms: Dental caries. Radiation dosage. Radiography, dental. Tomography, x-ray computed.

Hiperplasia angiolinfoide com eosinofilia: um caso raro em cavidade oral

Resumo A hiperplasia angiolinfoide com eosinofilia (HALE) é considerada uma lesão vascular benigna rara que acomete, principalmente, o tecido cutâneo e subcutâneo da região de cabeça e pescoço, mas incomum na cavidade oral. Sua etiopatogenia permanece indefinida, sendo descrita como proliferação vascular reacional, malformação vascular ou neoplasia. Tem como principal diagnóstico diferencial a doença de Kimura. Este trabalho relata um caso de um paciente do sexo masculino, de 50 anos, que exibia aumento de volume nodular na mucosa do lábio superior, com 3 cm de dimensão e 7 anos de evolução. Após a biópsia excisional, o exame histopatológico mostrou lesão bem encapsulada multilobulada com proliferação de capilares sanguíneos com células endoteliais de aspecto epitelioide, infiltrado inflamatório difuso com linfócitos, plasmócitos, inúmeros eosinófilos e presença de folículos linfoides. A análise imuno-histoquímica revelou positividade para CD34 e Ki-67, o que, juntamente com o exame morfológico, direcionou o diagnóstico para HALE.