Amorim Gomes

THERMAL STABILITY OF PREDNISONE DRUG AND TABLETS

TG and DSC data were used to determine the thermal parameters of prednisone drug and tablets. Two formulations of prednisone 20 mg were analysed in the form of tablets. The TG curves of prednisone drug and tablets A and B displayed six, eight and seven thermal decomposition processes, respectively. Analysis of the DSC data pointed to chemical interactions between prednisone drug and the excipients of tablets A and B, suggested by alterations in the melting temperature of prednisone. The analysis revealed that prednisone drug is more stable than tablets A and B.

Thermal behavior of anti-hypertensives drugs in solution and human plasma using DSC-cooling

The present study proposes the use of DSC-cooling as a fast tool to evaluate the drug behavior in biofluids submitted to freeze-thaw studies. Captopril, captopril+ascorbic acid and propranolol in plasma were submitted to 3 cycles of freeze-thaw using DSC-cooling up to 243 K. Captopril-plasma has suffered calorimetric alteration and revealed a considerable interaction front to freezing and heating processes. The presence of additive can stabilize the analyte in plasma. Propranolol-plasma presented reducing in phase transition enthalpy comparable to the plasma denatured by perchloric acid in the last cycles of freezing. DSC-cooling data demonstrated great potentiality for the freeze-thaw studies of drugs in biofluids.