Amrit Goswami

Microbial reduction of ω-bromoacetophenones in the presence of surfactants

Abstract Several ω-bromoacetophenone derivatives 6a – f were reduced to ( R )-(−)-2-bromo-1-(phenyl/substituted phenyl) ethanol derivatives 7a – f with whole cell biocatalysts in good yields. The enantiomeric excesses were increased to 95% using an anionic surfactant under an inert atmosphere in an aqueous medium.

A convenient stereoselective synthesis of (R)-(−)-denopamine and (R)-(−)-salmeterol

Abstract β-Adrenoreceptor agonists ( R )-(−)-denopamine ( R )- 1 and ( R )-(−)-salmeterol ( R )- 2 have been prepared in good overall yield and high enantioselectivity through a biotransformative pathway.

NEW DIRECT SYNTHESIS OF THIOAMIDES FROM CARBOXYLIC ACIDS

Abstract The synthesis of a series of thiomides by a novel one-pot reaction between carboxylic acids and amines in the presence of O , O -diethyl dithiophosphoric acid (DDTPA) is described.

A water based method for hydroxymethylation of phenols and phenolic ketones

A water based eco-friendly method for the hydroxymethylation of phenols and phenolic ketones has in good yield been developed.

An Efficient Method for One-Pot Reductive Cleavage of Acetals to Primary Alcohols Using a Bimetal Redox Couple CoCl2.6H2O-Zn

Acyclic or cyclic O,O-acetals and O,S-acetals underwent reductive cleavage to give primary alcohols efficiently on treatment with Zn-CoCl2.6H2O-bimetal redox system in dry tetrahydrofuran at ambient temperature to give good to excellent yields.