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Dive into the research topics where Ana Araceli Peña Fernández is active.

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Featured researches published by Ana Araceli Peña Fernández.


Nephrology Dialysis Transplantation | 2011

HIV infection and renal transplantation

A. Mazuecos; Ana Araceli Peña Fernández; Amado Andrés; E. Gómez; Sofia Zarraga; D. Burgos; Carlos Jiménez; Javier Paul; Alberto Rodriguez-Benot; Constantino Fernández

BACKGROUND Some aspects of kidney transplant outcome in human immunodeficiency virus (HIV)-infected patients are still controversial. Besides, published experience is scarce in Europe. METHODS A multicentre case-control study was designed to analyse the outcome of renal transplant in HIV + patients in Spain. Twenty HIV + patients were compared with a matched cohort of 40 HIV - recipients. RESULTS Post-transplant follow-up period was 39.98 ± 36.51 months. Pre-transplant dialysis duration and the incidence of pre-transplant opportunistic infections were significantly higher for HIV + patients. Following transplantation, HIV + recipients presented lower incidence of immediate renal function and more acute rejection. Graft survival was lower although the difference was not significant (1 year: 85 vs 97.5%; 5 years: 74.4 vs 91%; log-rank P = 0.058). There was no difference in patient survival rates. Eight patients in each group presented hepatitis C (HCV) infection. Coinfected patients were compared with HIV +/HCV - and HIV -/HCV + recipients. Coinfected patients presented more time on dialysis, greater duration of delayed graft function and lower graft survival (HIV +/HCV + vs HIV +/HCV -: log-rank P = 0.009; HIV +/HCV + vs HIV -/HCV +: log-rank P = 0.02). Conversely, when excluding HCV + patients in both groups, graft survival in HIV + and HIV - patients was similar. CONCLUSIONS The outcome was good, particularly in non-coinfected patients. Coinfected patients constitute an especially high-risk group for kidney transplantation.


American Journal of Kidney Diseases | 1997

Herpes Simplex Virus Encephalitis in a Renal Transplant Patient: Diagnosis by Polymerase Chain Reaction Detection of HSV DNA

E. Gómez; Santiago Melón; S. Aguado; JoséEmilio Sánchez; Carmen Portal; Ana Araceli Peña Fernández; A. Martínez; M. Sánchez; Jaime Alvarez

A case of herpes simplex virus (HSV) encephalitis with disseminated primary HSV infection in a renal transplant patient is described. The diagnosis of the disease was achieved by nested polymerase chain reaction (PCR)-DNA in cerebrospinal fluid (CSF). Other diagnostic measures (immunoglobulin [Ig] M and virological cultures both in blood and CSF) were negative. Blood IgG gave a false-positive signal. Although ganciclovir is not the drug of choice, its concomitant administration in our patient as a prophylactic measure against CMV infection may have decreased the usual severity normally expected in this kind of primary HSV infection. The subsequent increase in ganciclovir dose to full therapeutic range, which was implemented before the diagnosis was achieved, led to the disappearance of symptoms. The detection of PCR-DNA in CSF will probably become the diagnostic method of choice. One of its great advantages, in addition to its diagnostic reliability, is that it may obviate the performance of many cerebral biopsies.


Transplant International | 2013

High incidence of delayed graft function in HIV-infected kidney transplant recipients.

A. Mazuecos; Ana Araceli Peña Fernández; Sofia Zarraga; Amado Andrés; Alberto Rodriguez-Benot; Carlos Jiménez; E. Gómez; Javier Paul; Luisa Jimeno; Constatino Fernandez; D. Burgos; Ana Sánchez-Fructuoso; Lluís Guirado

Kidney transplantation (KT) outcomes in human immunodeficiency virus (HIV)‐infected recipients are under continuous research. High incidence of early post‐transplant complications such as acute rejection has been observed. A multicenter study including HIV‐infected patients who underwent KT in Spain, from 2001 to 2011, was performed. The study population included 108 recipients, 36 HIV‐infected, and 72 matched HIV‐negative KT recipients. HIV‐infected recipients developed more delayed graft function (DGF) (52% vs. 21%, P < 0.001). One‐ and 3‐year graft survival was 91.6% and 86.2% in HIV‐infected patients, and 97.1% and 94.7% in HIV‐negative patients (P = 0.052). In two‐variate Cox analysis, HIV infection was not a predictor of graft loss after adjusting for time on dialysis, acute rejection, and DGF. Multivariate analysis for DGF revealed HIV‐positive status as independent risk factor. We analyzed the evolution of immunosuppressive and antiretroviral therapy (ART). In HIV‐infected patients tacrolimus trough levels were very high in the first week and significantly lower in the second week post‐transplant (P = 0.042). Post‐transplant ART was significantly changed: protease inhibitors use decreased (P = 0.034) and integrase inhibitor use increased (P < 0.001). DGF is another frequent early complication in HIV‐infected recipients that can affect graft survival. Strategies to prevent DGF and antiretroviral regimes with less drug interactions could improve outcomes.


Transplantation direct | 2015

Medium-Term Renal Function in a Large Cohort of Stable Kidney Transplant Recipients Converted From Twice-Daily to Once-Daily Tacrolimus.

Lluís Guirado; D. Burgos; Carme Cantarell; Ana Araceli Peña Fernández; Antonio Franco; M.A. Gentil; A. Mazuecos; Josep Vicenç Torregrosa; Ernesto Gómez Huertas; J.C. Ruiz; Jaime Sánchez Plumed; Javier Paul; Ricardo Lauzurica; Sofia Zarraga; Antonio Osuna; Carlos Jiménez; Angel Carrancho Alonso; Alberto Cumpián Rodríguez; Beatriz Bardají; Domingo Hernández

Background There is some evidence pointing toward better renal function in kidney transplant recipients (KTR) treated with once-daily tacrolimus (QD-TAC) vs. twice-daily tacrolimus (BID-TAC). Methods This is an extension study of a 1-year, single arm prospective study of stable KTR who were converted from BID-TAC to QD-TAC (4.9 ± 4.0 years after transplantation) in Spanish routine clinical practice. Patient and graft survival, renal function, acute rejection episodes, and other analytic parameters were assessed at 24 and 36 months after conversion. Results A total of 1798 KTR were included in the extension study. Tacrolimus doses at 36 months were significantly lower compared to those at time of conversion (−0.2 mg/day; P = 0.023). Blood levels were lower than baseline during all the study (P < 0.001). Graft and patient survival at 3 years after conversion were 93.9% and 95.1%, respectively. Compared with baseline, the mean estimated glomerular filtration rate (eGFR) remained very stable at all timepoints (56.7 ± 19.8 vs 58.1 ± 24.6 mL/min per 1.73 m2 at month 36; P = 0.623). Even when patients reinitiating dialysis were counted as eGFR = 0, the mean eGFR was very stable. In fact, a small but significant increase was observed at 36 months versus baseline (+0.1 mL/min per 1.73 m2; P = 0.025). An increase in proteinuria was observed at 36 months versus baseline (+0.11 g/24 h; P < 0.001). Acute rejection rates were low during the study. Conclusions Conversion from BID-TAC to QD-TAC in a large cohort of stable KTR was safe and associated with a very stable renal function after 3 years. Comparative studies are warranted to assess the feasibility of such conversion.


Journal of Medical Virology | 2018

Human respiratory syncytial virus load normalized by cell quantification as predictor of acute respiratory tract infection

Miriam Gómez-Novo; José Antonio Boga; Marta Elena Álvarez-Argüelles; Susana Rojo-Alba; Ana Araceli Peña Fernández; María J Menéndez; María de Oña; Santiago Melón

Human respiratory syncytial virus (HRSV) is a common cause of respiratory infections. The main objective is to analyze the prediction ability of viral load of HRSV normalized by cell number in respiratory symptoms. A prospective, descriptive, and analytical study was performed. From 7307 respiratory samples processed between December 2014 to April 2016, 1019 HRSV‐positive samples, were included in this study. Low respiratory tract infection was present in 729 patients (71.54%). Normalized HRSV load was calculated by quantification of HRSV genome and human β‐globin gene and expressed as log10 copies/1000 cells. HRSV mean loads were 4.09 ± 2.08 and 4.82 ± 2.09 log10 copies/1000 cells in the 549 pharyngeal and 470 nasopharyngeal samples, respectively (P < 0.001). The viral mean load was 4.81 ± 1.98 log10 copies/1000 cells for patients under the age of 4‐year‐old (P < 0.001). The viral mean loads were 4.51 ± 2.04 cells in patients with low respiratory tract infection and 4.22 ± 2.28 log10 copies/1000 cells with upper respiratory tract infection or febrile syndrome (P < 0.05). A possible cut off value to predict LRTI evolution was tentatively established. Normalization of viral load by cell number in the samples is essential to ensure an optimal virological molecular diagnosis avoiding that the quality of samples affects the results. A high viral load can be a useful marker to predict disease progression.


Archive | 2002

Device for measuring behavior of foundation, has force measuring part measuring force exerted by hydraulic cylinder on foundation, and displacement measuring part measuring displacement of foundation under stress based on exerted force

José Antonio López Martínez; Antonio Madueño Luna; Ana Araceli Peña Fernández; Diego Luis Valera Martínez


Archive | 2016

Dispositivo para medir el comportamiento de cimentaciones ante un esfuerzo de tracción o de comprensión

Ana Araceli Peña Fernández; Diego Luis Valera Martínez; José Antonio López Martínez; Antonio Madueño Luna


Spanish Journal of Agricultural Research | 2013

Field analysis of the deterioration after some years of use of four insect-proof screens utilized in Mediterranean greenhouses

A. López Martínez; Diego Luis Valera Martínez; Francisco Domingo Molina Aiz; Ana Araceli Peña Fernández; Patricia Marín Membrive


15th European Congress of Endocrinology | 2013

Risk factors for impaired glucose tolerance and diabetes mellitus after liver transplantation

Guillermo Martínez; Gonzalo Allo; Ana Araceli Peña Fernández; Mercedes Aramendi; Carlos Jiménez; Enrique Moreno; Federico Hawkins


Vida rural | 2010

Ensayos de efectividad de los paneles evaporadores en invernaderos mediterráneos

Alejandro López; Diego Luis Valera Martínez; Francisco Domingo Molina Aiz; Ana Araceli Peña Fernández

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Carlos Jiménez

Hospital Universitario La Paz

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Amado Andrés

Complutense University of Madrid

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Ana Sánchez-Fructuoso

Complutense University of Madrid

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Domingo Hernández

Hospital Universitario de Canarias

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Enrique Moreno

Complutense University of Madrid

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