Ana Paula Galli Sanchez

Imunopatogênese da psoríase

A psoriase e doenca inflamatoria comum, afetando cerca de 1% da populacao brasileira. Os linfocito T auxiliares (Th17 e Th1) estao envolvidos na imunopatogenese da psoriase. Neste artigo e discutida a interacao entre a imunidade inata (especialmente celulas dendriticas e queratinocitos) e adquirida (linfocitos T) na patogenese da psoriase.

Estudo da proliferação linfocitária em pacientes sensibilizados ao níquel

FUNDAMENTO: O diagnostico da alergia ao niquel e estabelecido com a realizacao do teste de contato. OBJETIVO: Desenvolver um metodo diagnostico mais sensivel e especifico. CASUISTICAS E METODOS: Dezenove pacientes com teste de contato positivo para o niquel e 25 controles foram submetidos ao teste da proliferacao linfocitaria. As celulas mononucleadas foram isoladas do sangue venoso periferico e cultivadas em triplicatas, em placas de cultura (2x105 celulas/orificio) com: meio de cultura apenas; sulfato de niquel (156,25; 78,13; 19,53; 9,77 e 2,44µM) e concentracoes ideais do antigeno Candida albicans e dos mitogenos pokeweed, fito-hemaglutinina A e anticorpo anti-CD3 (OKT3). Timidina tritiada foi adicionada as placas, a radioatividade incorporada pelas celulas medida e os resultados expressos pelo indice de estimulacao (IE). RESULTADOS: A resposta proliferativa dos linfocitos dos casos foi superior a dos controles em todas as concentracoes de niquel testadas. Considerando teste positivo para niquel quando IE > 3, nenhum dos controles e 16 (84,21%) dos casos apresentaram teste positivo em pelo menos uma das cinco concentracoes usadas. As respostas a Candida albicans e aos mitogenos foram semelhantes nos casos e controles, demonstrando a integridade da imunidade celular em ambos os grupos. CONCLUSAO: O teste da proliferacao linfocitaria mostra-se util no diagnostico da alergia ao niquel.

Primary essential cutis verticis gyrata - Case report

Cutis verticis gyrata is characterized by excessive formation of scalp skin. It may be primary (essential and nonessential) or secondary. In the primary essential form it presents only folding skin formation on the scalp, mimicking cerebral gyri, without associated comorbidities. We report a rare case of a 28 year-old male patient with primary essential cutis verticis gyrata.

Linear IgA bullous dermatosis: report of an exuberant case

Linear immunoglobulin A dermatosis is a rare autoimmune bullous disease, but the most common autoimmune bullous dermatosis in children. We report a typical exuberant case of linear IgA dermatosis in a ten-month old child, who showed good response to treatment with corticosteroids and dapsone.

Tungíase disseminada tratada com ivermectina

A tungiase e ectoparasitose causada pela penetracao da Tunga penetrans na pele do hospedeiro. A infestacao por essa pulga esta associada a pobreza e ocorre em comunidades carentes na America do Sul e Central, no Caribe e na Africa sul-sahariana. No Brasil, e mais prevalente em assentamentos urbanos precarios, areas rurais e comunidades de pescadores em todo o pais. O tratamento consiste na retirada dos parasitas e, nos casos com infeccao secundaria, antibioticoterapia. Ate o momento, nao ha droga no mercado com eficacia clinica satisfatoria. Relata-se caso de tungiase disseminada tratada com ivermectina oral.

Síndrome de Sweet em cicatriz cirúrgica

Sweets syndrome is a rare dermatosis, characterized by acute tender erythematous plaques or nodules. The case of a 55-year old woman with a skin lesion compatible with Sweets syndrome surrounding a surgical scar on the face, after removing an actinic keratosis lesion, and using dipyrone is reported. The reported case points to the possibility of the occurrence of Koebner phenomenon in Sweets syndrome, probably triggered by the use of dipyrone

The importance of trichological examination in the diagnosis of alopecia areata.

In this article we discuss the propedeutic aspects of alopecia areata, especially those found by dermatoscopy, an invaluable tool for diagnosis of the condition. Dermatoscopy facilitates the early detection of the characteristic changes in alopecia areata hair such as exclamation-point hairs, cadaverous hair, fuzzy hair, vellus type hair and yellow spots.

Penfigoide bolhoso no adulto mais jovem: relato de três casos

Bullous pemphigoid is an autoimmune subepidermal bullous dermatosis more commonly observed in the elderly (over 70 years old). Autoantibodies are produced for specific antigens of the epidermal basement membrane zone: BP 180 and BP 230 (hemidesmosome proteins). We report three cases of bullous pemphigoid in adults younger than 50 years old, discussing the clinical characteristics of the disease in younger patients.

Epidermólise bolhosa adquirida inflamatória: relato de caso

We report a case of an inflammatory variant of epidermolysis bullosa acquisita in a 53-year-old male, with itching blistering eruption on the trunk, armpits and limbs for six months. The skin biopsy specimen showed subepidermal blister with neutrophils. Direct immunofluorescence revealed linear depositions of IgG, IgA, IgM and C3 at the basement membrane; indirect immunofluorescence and salt Split Skin were negative. Antinuclear antibodies were also negative. Improvement of the blisters followed treatment with systemic corticotherapy and some lesions healed with milia. This is a rare presentation of epidermolysis bullosa acquisita, with inflammatory lesions at first.

Dermatose por IgA linear induzida pela gestação

Linear IgA disease is a rare autoimmune subepidermal bullous disorder characterized by linear IgA deposits at the epidermal basement membrane zone. According to the literature, in patients who have linear IgA disease and become pregnant, the disease tends to improve. We report a case of linear IgA disease induced by pregnancy, successfully treated with dapsone and prednisone with no adverse effects observed in the patient and her newborns.