Anand M. Prabhakar
Harvard University
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Featured researches published by Anand M. Prabhakar.
Thrombosis and Haemostasis | 2003
Stephanie Pitsilos; Jennifer L. Hunt; Emile R. Mohler; Anand M. Prabhakar; Mortimer Poncz; Jennine Dawicki; Tigran Z. Khalapyan; Megan L. Wolfe; Ronald M. Fairman; Marc E. Mitchell; Jeffrey P. Carpenter; Michael A. Golden; Douglas B. Cines; Bruce S. Sachais
Emerging evidence supports a role for platelets in the progression of atherosclerosis in addition to an involvement in thrombotic vascular occlusion. Platelet Factor 4 (PF4), a chemokine released by activated platelets, stimulates several pro-atherogenic processes. Therefore, we examined the localization of PF4 and the homologous protein, Neutrophil Activating Protein-2 (NAP-2) in lesions representing the evolution of human atherosclerotic plaques. Carotid plaques from 132 patients with critical carotid stenosis and 6 autopsy specimens were studied. Clinical, histologic and immunohistochemical data were analyzed using a chi(2)-test. PF4 was detected in the cytoplasm of luminal and neovascular endothelium, in macrophages and in regions of plaque calcification. The presence of PF4 in macrophages and neovascular endothelium correlated with lesion grade (p = 0.004; p = 0.044). Staining of macrophages for PF4 correlated with the presence of symptomatic atherosclerotic disease (p = 0.028). In early lesions, PF4 was commonly found in macrophages of early lesions (Grade I/II), whereas NAP-2 was rarely present. In conclusion, correlation between PF4 deposition, lesion severity and symptomatic atherosclerosis suggests that persistent platelet activation may contribute to the evolution of atherosclerotic vascular lesions. These studies support the rationale for the chronic use of anti-platelet therapy in patients at risk for developing symptomatic atherosclerosis.
Journal of The American College of Radiology | 2016
H. Benjamin Harvey; Tarik K. Alkasab; Anand M. Prabhakar; Elkan F. Halpern; Daniel I. Rosenthal; Pari V. Pandharipande; G. Scott Gazelle
PURPOSE The objective of this study was to evaluate the feasibility of the consensus-oriented group review (COGR) method of radiologist peer review within a large subspecialty imaging department. METHODS This study was institutional review board approved and HIPAA compliant. Radiologist interpretations of CT, MRI, and ultrasound examinations at a large academic radiology department were subject to peer review using the COGR method from October 2011 through September 2013. Discordance rates and sources of discordance were evaluated on the basis of modality and division, with group differences compared using a χ(2) test. Potential associations between peer review outcomes and the time after the initiation of peer review or the number of radiologists participating in peer review were tested by linear regression analysis and the t test, respectively. RESULTS A total of 11,222 studies reported by 83 radiologists were peer reviewed using COGR during the two-year study period. The average radiologist participated in 112 peer review conferences and had 3.3% of his or her available CT, MRI and ultrasound studies peer reviewed. The rate of discordance was 2.7% (95% confidence interval [CI], 2.4%-3.0%), with significant differences in discordance rates on the basis of division and modality. Discordance rates were highest for MR (3.4%; 95% CI, 2.8%-4.1%), followed by ultrasound (2.7%; 95% CI, 2.0%-3.4%) and CT (2.4%; 95% CI, 2.0%-2.8%). Missed findings were the most common overall cause for discordance (43.8%; 95% CI, 38.2%-49.4%), followed by interpretive errors (23.5%; 95% CI, 18.8%-28.3%), dictation errors (19.0%; 95% CI, 14.6%-23.4%), and recommendation (10.8%; 95% CI, 7.3%-14.3%). Discordant cases, compared with concordant cases, were associated with a significantly greater number of radiologists participating in the peer review process (5.9 vs 4.7 participating radiologists, P < .001) and were significantly more likely to lead to an addendum (62.9% vs 2.7%, P < .0001). CONCLUSIONS COGR permits departments to collect highly contextualized peer review data to better elucidate sources of error in diagnostic imaging reports, while reviewing a sufficient case volume to comply with external standards for ongoing performance review.
Cardiovascular diagnosis and therapy | 2016
Gita Yashwantrao Karande; Sandeep Hedgire; Yadiel Sánchez; Vinit Baliyan; Vishala Mishra; Suvranu Ganguli; Anand M. Prabhakar
Deep venous thrombosis (DVT) affecting the extremities is a common clinical problem. Prompt imaging aids in rapid diagnosis and adequate treatment. While ultrasound (US) remains the workhorse of detection of extremity venous thrombosis, CT and MRI are commonly used as the problem-solving tools either to visualize the thrombosis in central veins like superior or inferior vena cava (IVC) or to test for the presence of complications like pulmonary embolism (PE). The cross-sectional modalities also offer improved visualization of venous collaterals. The purpose of this article is to review the established modalities used for characterization and diagnosis of DVT, and further explore promising innovations and recent advances in this field.
Journal of The American College of Radiology | 2015
Aaron B. Paul; Rahmi Oklu; Sanjay Saini; Anand M. Prabhakar
PURPOSE To extend the investigation of price transparency and variability to medical imaging. METHODS Eighteen upper-tier academic hospitals identified by U.S. News & World Report and 14 of the 100 largest private radiology practices in the country identified by the Radiology Business Journal were contacted by telephone between December 2013 and February 2014 to determine the cash price for a noncontrast head CT. The price for a noncontrast head CT was chosen to assess price transparency in medical imaging because it represents a standard imaging examination with minimal differences in quality. RESULTS Fourteen upper-tier academic hospitals (78%) and 11 private practices (79%) were able to provide prices for a noncontrast head CT. There was no significant difference between the proportions of upper-tier academic hospitals and private practices that were able to provide prices for a noncontrast head CT (P = .96). The average total price for the upper-tier academic hospitals was
Journal of The American College of Radiology | 2015
H. Benjamin Harvey; Tarik K. Alkasab; Pari V. Pandharipande; Elkan F. Halpern; Anand M. Prabhakar; Rahmi Oklu; Daniel I. Rosenthal; Joshua A. Hirsch; G. Scott Gazelle; James A. Brink
1,390.12 ±
Magnetic Resonance Imaging Clinics of North America | 2010
Priya D. Prabhakar; Anand M. Prabhakar; Hima B. Prabhakar; Duyshant Sahani
686.13, with the price ranging from
Journal of Vascular and Interventional Radiology | 2015
Rahmi Oklu; Derek A. Haas; Robert S. Kaplan; Katelyn N. Brinegar; Nicole Bassoff; H. Benjamin Harvey; James A. Brink; Anand M. Prabhakar
391.62 to
Critical Reviews in Biotechnology | 2017
Katelyn N. Brinegar; Ali K. Yetisen; Sun Choi; Emily Vallillo; Guillermo U. Ruiz-Esparza; Anand M. Prabhakar; Ali Khademhosseini; Seok Hyun Yun
2,015. The average total price for the private practices was
Current Problems in Diagnostic Radiology | 2016
Refky Nicola; Khalid W. Shaqdan; Shima Aran; Anand M. Prabhakar; Ajay K. Singh; Hani H. Abujudeh
681.60 ±
Radiology | 2014
Anand M. Prabhakar; H. Benjamin Harvey; Judy T. Platt; James A. Brink; Rahmi Oklu
563.58, with the total price ranging from