Anat Cohen-Dayag
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Featured researches published by Anat Cohen-Dayag.
Diabetes | 2011
Reut Ashwal; Rina Hemi; Amir Tirosh; Reut Gordin; Eleanor Yissachar; Anat Cohen-Dayag; Avi Rosenberg; Avraham Karasik; Matthias Blüher; Hannah Kanety
OBJECTIVE Adiponectin receptor-1 (AdipoR1) expression in skeletal muscle has been suggested to play an important role in insulin resistance and diabetes. We aimed at evaluating the presence of novel AdiopR1 splice variants in human muscle and their regulation under physiological and pathophysiological states. RESEARCH DESIGN AND METHODS AdipoR1 5′UTR mRNA transcripts, predicted from bioinformatics data, were evaluated in fetal and adult human tissues. Expression and function of the identified transcripts were assessed in cultured human skeletal muscle cells and in muscle biopsies obtained from individuals with normal glucose tolerance (NGT) and type 2 diabetes (n = 49). RESULTS Screening of potential AdipoR1 5′UTR splice variants revealed a novel highly abundant muscle transcript (R1T3) in addition to the previously described transcript (R1T1). Unlike R1T1, R1T3 expression was significantly increased during fetal development and myogenesis, paralleled with increased AdipoR1 protein expression. The 5′UTR of R1T3 was found to contain upstream open reading frames that repress translation of downstream coding sequences. Conversely, AdipoR1 3′UTR was associated with enhanced translation efficiency during myoblast-myotube differentiation. A marked reduction in muscle expression of R1T3, R1T1, and R1T3-to-R1T1 ratio was observed in individuals with type 2 diabetes compared with expression levels of NGT subjects, paralleled with decreased expression of the differentiation marker myogenin. Among NGT subjects, R1T3 expression was positively correlated with insulin sensitivity. CONCLUSIONS These results indicate that AdipoR1 receptor expression in human skeletal muscle is subjected to posttranscriptional regulation, including alternative splicing and translational control. These mechanisms play an important role during myogenesis and may be important for whole-body insulin sensitivity.
Archive | 2006
Sarah Pollock; Anat Cohen-Dayag; Osnat Sella-Tavor; Shirley Sameah-Greenwald; Shira Walach; Lily Bazak
Archive | 2008
Zurit Levine; Tania Pergam; Dalit Landesman-Milo; Anat Cohen-Dayag; Amir Toporik; Yaron Kinar; Sergey Nemzer; Avi Rosenberg; Galit Rotman; Amit Novik; Cynthia Koifman; Merav Beiman; Liat Dassa; Shira Walach; Eve Montia; Shirley Sameach-Greenwald; Ofer Levy; Marina Bubis
Archive | 2010
Yaron Kinar; Merav Beiman; Eve Montia; Shira Walach; Tania Pergam; Amit Novik; Shirley Sameah-Greenwald; Gad S. Cojocaru; Anat Cohen-Dayag; Yael Furman
Archive | 2009
Amit Novik; Liat Dassa; Merav Beiman; Shirley Sameah-Greenwald; Anat Cohen-Dayag; Gad S. Cojocaru
Archive | 2009
Zurit Levine; Avi Rosenberg; Galit Rotman; Amir Toporik; Eve Montia; Anat Cohen-Dayag; Shira Walach; Shirley Sameach-Greenwald; Liat Dassa; Merav Beiman; Ofer Levy; Amit Novik; Yaron Kinar; Sergey Nemzar
Archive | 2016
Shira Walach; Zurit Levine; Galit Rotman; Amit Novik; Shirley Sameah-Greenwald; Anat Cohen-Dayag; Amir Toporik; Liat Dassa; Avi Rosenberg; Yaron Kinar; Sergey Nemzer; Cynthia Koifman; Merav Beiman; Eve Montia; Tania Pergam; Dalit Milo; Ofer Levy; Marina Bubis
Archive | 2016
Shira Walach; Zurit Levine; Galit Rotman; Amit Novik; Shirley Sameah-Greenwald; Anat Cohen-Dayag; Amir Toporik; Liat Dassa; Avi Rosenberg; Yaron Kinar; Sergey Nemzer; Cynthia Koifman; Merav Beiman; Eve Montia; Tania Pergam; Dalit Milo; Ofer Levy; Marina Bubis
Archive | 2015
Zurit Levine; Avi Rosenberg; Galit Rotman; Amit Novik; Amir Toporik; Yaron Kinar; Sergey Nemzer; Cynthia Koifman; Merav Beiman; Liat Dassa; Shira Walach; Eve Montia; Shirley Greenwald; Tania Pergam; Dalit Milo; Anat Cohen-Dayag; Oler Levy; Marina Bubis
Archive | 2015
Shira Walach; Galit Rotman; Amit Novik; Gad S. Cojocaru; Shirley Sameah-Greenwald; Amir Toporik; Liat Dassa; Avi Rosenberg; Yaron Kinar; Sergey Nemzer; Merav Beiman; Eve Montia; Zurit Levine; Anat Cohen-Dayag; Ofer Levi