Anatoli Dimoglo

Experimental and theoretical study on catalytic ozonation of humic acid by ZnO catalyst

ABSTRACT Ozonation and catalytic ozonation of humic acid (HA) in the presence of ZnO were examined in a batch scale reactor. The degradation of HA by catalytic ozonation was found to be much more effective than ozonation alone. The quantum chemistry calculations showed that the reaction of the O3 disproportionation on the surface of ZnO corresponds to the barrierless mechanism. The activation energy of the transition state formation was −5.25 eV. The active oxygen atom formed on the surface of ZnO was found as interacting with both water molecules and dissolved organic molecules, which might lead to further oxidizing reactions.

Kanser İlaçları Atıksularının Elektrooksidasyon Prosesi ile Giderimi

Bu calismada, kanser ilaclari ureten fabrikadan temin edilen Metotraksat (MTX), Iyoheksol (IOX) ve Kapasitabin (CPC) iceren atiksularin, elektrooksidasyon prosesi ile giderimi calisilmistir. Anodik oksidasyon karisik metal oksit (KMO) (Ti/IrO2-Ru, Ti/Ru, Ti/IrO2-Ru (EC 300)) ve bor katkili elmas (BKE) elektrotlar kullanilarak saglanmistir. Karisik metal oksit elektrotlar ile MTX, CPC ve IOX icin sirasiyla %56,8, %35,4 ve %52 giderim verimi elde edilmistir. Bor katkili elmas elektrot ile yurutulen elektrooksidasyon prosesi ile elde edilen giderim verimleri MTX, CPC ve IOX icin sirasiyla %86,1, %99,0 ve %53,4 olarak tespit edilmistir. Daha yuksek gerilim potansiyeline sahip BKE elektrotlar, elektrooksidasyon prosesinde kullanilan KMO elektrot materyallerine gore daha yuksek giderim verimi saglamistir.

Elektro-oksidasyon Prosesi ile Methotrexate Gideriminin Yüzey Yanıt Metodu ile Optimizasyonu

Atik sularda bulunan ilac kalintilari sucul ortam uzerinde oldukca toksik etkilere sebep olmalari nedeniyle birincil kirleticiler kapsaminda degerlendirilmeye baslanmistir. Atik sularda ve yuzeysel sularda ilac kalintilarinin konsantrasyonlari µg/L ve ng/L gibi cok dusuk seviyelerde olmasina ragmen kronik etkileri nedeniyle arastirma yapilmasina gerek duyulmaktadir. Bu toksik kimyasallar, biyo-bozunur olmadiklarindan dolayi su ve atik sulardan gidermek icin klasik biyolojik aritma yontemleri yetersiz kalmaktadir. Bu yuzden ileri aritma yontemlerinin gelistirilmesi oldukca onemlidir. Ozellikle elektrokimyasal aritma yontemleri bu tur kimyasallari aritmak icin oldukca basarili yontemler olarak dikkat cekmektedir. Bu calismada, Methotrexate (MTX) adli etken maddenin elektro-oksidasyon yontemi ile aritimi calisilmistir. MTX uzun yillardir kanser tedavisinde yaygin olarak kullanilan bir kimyasaldir. Calismada, Ti/IrO 2 /RuO 2 karisik metal oksit elektrotu kullanilmistir. Optimum calisma sartlarinin belirlenmesi amaciyla yuzey yanit metodu (YYM) kullanilarak elektro-oksidasyon metodunun MTX giderimi icin optimizasyonu yapilmistir.

Degradation of Toxic Indigo Carmine Dye by Electrosynthesized Ferrate (VI)

Response surface methodology was applied for optimizing indigo carmine (IC) dye removal by electrochemically produced ferrate (VI). Box-Behnken design was employed in this study, and design parameters were pH, Fe (VI) dose and initial dye concentration (C o ). R 2 and adjusted R 2 values were very high that indicated very good accuracy for the employed model. Optimum operational conditions were: 4.08-7.69 for pH, 24-118.83 mg/L for Fe (VI) dose and 60.68-99.13 mg/L for complete removal of IC. Produced by electrochemical method Ferrate (VI) provides high effectiveness for IC dye-containing synthetic wastewater.

Marginally designed new profen analogues have the potential to inhibit cyclooxygenase enzymes.

The current structure–activity relationship of profens (i.e., 2‐arylpropionic acid derivatives, a class of non‐steroidal anti‐inflammatory drugs) discusses the importance of α‐monomethyl substitution on these compounds, since the activities obtained through their corresponding arylacetic acid derivatives (i.e., α‐demethylated derivatives) or α,α‐dimethyl‐substituted compounds are less than what is observed for the parent profens. Unfortunately, this implies a generalization in structure–activity relationships of profens in such a way that a mono‐(non‐methyl)alkyl group or dialkyl substituent replaced at the α‐position of a profen analogue results in abolished activity. Therefore, within this study, we aimed to question this generalization employing ibuprofen, flurbiprofen, and naproxen as model compounds. A series of α‐(non‐methyl)alkyl‐substituted ibuprofen and flurbiprofen analogues as well as α,α‐dialkyl‐substituted ibuprofen, flurbiprofen, and naproxen derivatives were synthesized and screened for their potential to inhibit cyclooxygenase enzymes. In addition, since profens have negligible potential to inhibit lipoxygenase enzymes, the effect of such derivatization was also questioned in lipoxygenase inhibition assays. The findings only partially agreed with the current structure–activity approach of profens and the activity results of some compounds were found as beyond ordinary.