Anders Hallberg

Anders Hallberg; Arnold R. Martin

Abstract Derivatives of 1-chlorophenothiazine, possessing different basic side chains on the nitrogen atom, have attracted the attention of medicinal chemists in the past.1–5 Our interest in the title compound 1 stems from reports that 1-chloropromazine 25 and the corresponding trans-2-(l-chloro- lo-phenothiazinyl)-N,N-dimethylcyclopropane methylamine derivative (314 exhibit antidepressant (but not antipsychotic activity) in experimental animals. A literature survey revealed that multistep syntheses were required for the preparation of I-chlorophenothiazine (1)6-9. It has however been obtained in a single step procedure by heating a complex of phenothiazine with cupric chloride, but the yield was very low, 1.5%10.

Anders Hallberg; Arne Svensson; Arnold R. Martin

Abstract Certain 2-substituted N-acylphenothiazines undergo a rapid intramol≐cular N→C migration on reaction with lithium N,N-dialkylamides at −78°. Preliminary studies of the scope and mechanism of this anionic version of the Fries rearrangement are reported.

Anders Hallberg; Torsten Dahlgren; Arnold R. Martin; Kenner Christiansen

The total assignment of the 1H nmr spectrum of the three tetracyclic compounds: 5H -indolo[1,7-ab][1]benzazepine,6,7-dihydro-5H -indolo[1,7-ab ][1]benzazepine and pyrrolo[3,2,1-kl ]phenothiazine is described. Assignments were based on decoupling experiments and the spectrum of 1,10-dideuteriopyrrolo[3,2,1-kl]phenothiazine and the spectral parameters were verified by spin-simulation techniques. A temperature study of 6,7-dihydro-5H -indolo[1,7-ab][1]benzazepine was also performed.

Anders Hallberg; Arnold R. Martin

Anders Hallberg; Arnold R. Martin

Anders Hallberg; Ibrahim Al-Showaier; Arnold R. Martin

Anders Hallberg; Ibrahim Al-Showaier; Arnold R. Martin

Tomas Klingstedt; Anders Hallberg; Philip Dunbar; Arnold R. Martin

Anders Hallberg; Ibrahim Al-Showaier; Arnold R. Martin

Torsten Dahlgren; Anders Hallberg; R. Helitzer; Arnold R. Martin