Andi Yasmon
University of Indonesia
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Publication
Featured researches published by Andi Yasmon.
Journal of Medical Microbiology | 2015
Yeva Rosana; Andi Yasmon; Delly Chipta Lestari
Fluconazole is the standard treatment for oropharyngeal candidiasis, which is the third most common opportunistic infection in human immunodeficiency virus (HIV)/AIDS patients in Indonesia. Overuse of this drug could lead to the emergence of resistance. The objective of this study was to analyse the role of ERG11, CDR1, CDR2 and MDR1 gene overexpression and mutations in the ERG11 gene as a genetic mechanism of fluconazole resistance in Candida albicans isolated from HIV patients in Indonesia. Overexpression of ERG11, CDR1, CDR2 and MDR1 was analysed by real-time reverse transcription PCR, while ERG11 gene mutation analysis was performed using sequencing methods. Seventeen isolates out of 92 strains of C. albicans isolated from 108 HIV patients were found to be resistant to azole antifungals. The highest gene overexpression of ERG11 was found in C. albicans resistant to single fluconazole, while the highest gene overexpression of CDR2 was detected in all isolates of C. albicans resistant to multiple azoles. Amino acid substitutions were observed at six positions, i.e. D116E, D153E, I261V, E266D, V437I and V488I. The amino acid substitution I261V was identified in this study and was probably associated with fluconazole resistance. The combination of overexpression of CDR2 and ERG11 and mutation in the ERG11 gene was found to be a genetic mechanism of fluconazole resistance in C. albicans isolated from HIV patients in Indonesia.
Medical Journal of Indonesia | 2010
A. Tarini; H. Wahid; Fera Ibrahim; Andi Yasmon
Makara Journal of Health Research | 2011
Andi Yasmon; Elisabeth D. Harahap; Pramita G. Dwipoerwantoro; Beti Ernawati Dewi
Medical Journal of Indonesia | 2010
Andi Yasmon; Ni Nengah Dwi Fatmawati; Fera Ibrahim; Budiman Bela
Medical Journal of Indonesia | 2010
Andi Yasmon; Yusmaniar Yusmaniar; Anis Anis; Budiman Bela
Microbiology Indonesia | 2012
Andi Yasmon; Yulianty Muhayar; Vivi Setiawaty; Beti Ernawati Dewi; Budiman Bela; Fera Ibrahim
Medical Journal of Indonesia | 2012
Anis Karuniawati; Andi Yasmon; Ika Ningsih
Universa Medicina | 2018
Ida Effendi; Yeva Rosana; Andi Yasmon; Wresti Indriatmi
Makara Journal of Health Research | 2018
Mardhia Mardhia; Effiana Effiana; Abror Irsan; Diana Natalia; Sari Rahmayanti; Junita Indarti; Lisnawati Rachmadi; Andi Yasmon
African Journal of Infectious Diseases | 2018
Desi Indriarini; Andriansjah Rukmana; Andi Yasmon