András Vargha

Patterns of mood changes throughout the reproductive cycle in healthy women without premenstrual dysphoric disorders

OBJECTIVE The cyclic nature of female reproductive function is a natural part of life accompanied by changes in several physical and psychological phenomena. The aim of our study was to investigate the fluctuation of psychological symptoms throughout the female reproductive cycle in healthy, non-PMDD (premenstrual dysphoric disorder) women. METHOD 63 psychiatrically healthy, non-PMDD women with normal regular menstrual cycles and not using hormonal contraceptive methods participated in the study. Participants completed the PRISM (Prospective Record of the Impact and Severity of Menstrual Symptoms) calendar every night for three cycles and in addition they completed several other psychometric measures (Symptom Distress Checklist-SCL-51, State Trait Anxiety Inventory-STAI, Zung Self-rating Depression Scale-ZSDS, Eating Attitude Test-EAT, Mind and Body Cathexis Scale) at three predefined days of the first cycle. Based on an at least 66% increase in physical symptoms from the late follicular to the late luteal phase on the PRISM, subjects were assigned to luteal phase physical symptoms (LPPS) and no luteal phase physical symptoms (nonLPPS) groups. The association of psychometric scores with timing within the cycle and with physical symptoms was analysed. RESULTS Significant changes in psychometric scores over time were observed for STAI state anxiety, SCL anxiety, SCL somatization, SCL depression, SCL obsessive-compulsive, SCL interpersonal sensitivity, SCL total, and ZSDS. A significant timexLPPS grouping interaction emerged in case of the SCL somatization subscale and the ZSDS. LPPS grouping was associated with only the interpersonal sensitivity subscale of the SCL51. CONCLUSION Our results indicate that there is a significant increase in psychological symptoms related to neuroticism and depression from the late follicular to the late luteal phase in a healthy, non-PMDD female population. Although our results may not have direct clinical significance, since the statistically significant increases in psychometric scores are still small, it is an important finding that there is a consistent pattern observable in the fluctuation of psychological symptoms accompanying the female reproductive cycle.

Enhancement of creative expression and entoptic phenomena as after-effects of repeated ayahuasca ceremonies

Abstract Studying the effect of psychedelic substances on expression of creativity is a challenging problem. Our primary objective was to study the psychometric measures of creativity after a series of ayahuasca ceremonies at a time when the acute effects have subsided. The secondary objective was to investigate how entoptic phenomena emerge during expression of creativity. Forty individuals who were self-motivated participants of ayahuasca rituals in Brazil completed the visual components of the Torrance Tests of Creative Thinking before and the second day after the end of a two-week long ceremony series. Twenty-one comparison subjects who did not participate in recent psychedelic use also took the Torrance tests twice, two weeks apart. Repeated ingestion of ayahuasca in the ritual setting significantly increased the number of highly original solutions and phosphenic responses. However, participants in the ayahuasca ceremonies exhibited more phosphenic solutions already at the baseline, probably due to the fact that they had more psychedelic experiences within six months prior to the study than the comparison subjects did. This naturalistic study supports the notion that some measures of visual creativity may increase after ritual use of ayahuasca, when the acute psychoactive effects are receded. It also demonstrates an increased entoptic activity after repeated ayahuasca ingestion.

Matching method to problem: A developmental science perspective

In developmental research there is quite often a mismatch between the scientific problem and the methods used to address it. In this article we discuss what this mismatch is about and we suggest some remedies. Our discussion is confined to typical matching situations that arise within a developmental science (DS) theoretical framework. A number of measurement issues are brought up including variable standardization and how to measure change. It is argued that to study individual development precise measurements are necessary and that, for this purpose, most measures currently used in developmental research are not sufficiently reliable. Further, we discuss the choice of a statistical method suitable for analysis within a DS framework and it is concluded that increased use should be made of person-oriented methods and methods developed for studying nonlinear dynamic systems. Finally, causality issues are discussed and a distinction is made between the study of average and individual causality.

Interfacial behaviour of poly(lactic acid) and Pluronic6400 mixed monolayers at the air-water interface

Interfacial properties of spread monolayers of poly(lactic acid), PLA and poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) block copolymer (Pluronic6400) have been studied at the air–water interface by measuring surface pressure–area isotherms. Film balance experiments were also performed on the mixed layers of PLA and Pluronic6400 over a wide concentration range. Transitions observed of the isotherms compressing the pure Pluronic6400 monolayer could be correlated to conformational changes of other PEO-containing type copolymers interpreted by the scaling theory. In the mixed systems, the Pluronic6400 additive exhibited a concentration-dependent influence on the behaviour and structural changes of the PLA film. The maximum effect on phase transition of PLA monolayer and compressibility was obtained at 100∶60 PLA/Pluronic6400 weight ratio. Analysis of the additivity of the components revealed that the mixed films are miscible and non-ideal systems with high deviation from ideality. The interaction existing in the PLA–Pluronic6400 monolayer results in contraction in the low surface pressure range where the film is characterized by low compressibility, while in the compressed state dynamic effects might also contribute to the expansion of the mixed films.

Cross-Cultural Applicability of FACES IV

We studied cross-cultural Hungarian adaptation and validation of FACES IV for screening adaptive versus nonadaptive family functioning. A protocol was followed including translation, tests of reliability, construct and convergent validity, standardization, testing of family types, and ratios. Two hundred forty-nine couples (498 adults) from various regions of the country participated in the study. Results indicated high item–remainder correlations and Cronbach alphas. Factor analytic data fitted well with the model indicated by the Olson studies. Most salient results were found for Cohesion, which partially overlapped Flexibility, and had high negative correlations with the Disengaged dimension. Rigid and Chaotic as well as Enmeshed were found to be independent factors. Family types of the Hungarian sample explored by cluster analysis were comparable to the U.S. sample.

Online and offline video game use in adolescents: measurement invariance and problem severity

ABSTRACT Background: Despite the increasing popularity of video game playing, little is known about the similarities and differences between online and offline video game players. Objectives: The aims of this study were (i) to test the applicability and the measurement invariance of the previously developed Problematic Online Gaming Questionnaire (POGQ) in both online and offline gamers and to (ii) examine the differences in these groups. Methods: Video game use habits and POGQ were assessed in a sample of 1,964 (71% male) adolescent videogame players. Those gamers who played at least sometimes in an online context were considered “online gamers,” while those who played videogames exclusively offline were considered “offline gamers.” Results: Confirmatory factor analysis supported the measurement invariance across online and offline videogame players. According to the multiple indicators multiple causes (MIMIC) model, online gamers were more likely to score higher on overuse, interpersonal conflict, and social isolation subscales of the POGQ. Conclusion: The results of the present study suggest that online and offline gaming can be assessed using the same psychometric instrument. These findings open the possibility for future research studies concerning problematic video gaming to include participants who exclusively play online or offline games, or both. However, the study also identified important structural features about how online and offline gaming might contribute differently to problematic use. These results provide important information that could be utilized in parental education and the prevention program about the possible detrimental consequences of online vs. offline video gaming.

The possible protective role of personality dimensions against premenstrual syndrome

Previous studies suggest that women with premenstrual syndrome (PMS) differ from those without PMS in personality dimensions, but it is not clear what role personality plays in the background of premenstrual symptomatology. Our purpose was to examine personality dimensions measured by the Tridimensional Character Inventory (TCI) in psychiatrically healthy women not suffering from premenstrual dysphoric disorder (PMDD) in relation to the severity of distressing and impairing mental and physical symptoms experienced in the late luteal phase of the menstrual cycle. Forty healthy women completed the prospective record of the Impact and Severity of Menstrual Symptoms (PRISM) calendar every evening through three consecutive menstrual cycles and were assigned into LPS (luteal phase symptom) vs. non-LPS groups. Our grouping did not reflect categorization according to the presence of PMS, since we investigated healthy women. Personality characteristics were evaluated using the TCI. LPS subjects scored significantly higher in subscales associated with novelty seeking (NS), self-directedness (S), cooperation (C) and self-transcendence (ST), and lower in the harm avoidance (HA) scale. Elevated scores of women with higher symptom severity in the late luteal phase in NS, S, ST and C scales and lower HA scores are in contrast with previous results on personality traits associated with PMS. However, we investigated psychiatrically healthy women. Therefore, our results suggest that this personality profile is a protective factor against developing serious psychiatric symptoms when experiencing a distressing and more marked symptomatology associated with the late luteal phase of the reproductive cycle.

Different types of sensation seeking A person-oriented approach in sensation-seeking research

Previous research on sensation seeking (SS) was dominated by a variable-oriented approach indicating that SS level has a linear relation with a host of problem behaviors. Our aim was to provide a person-oriented methodology—a probabilistic clustering—that enables examination of both inter- and intra-individual differences in not only the level, but also in the pattern of SS. We have applied model-based clustering to a four-semester long longitudinal high school survey (N = 3334) and to a cross-sectional university survey (N = 438). The results indicated that impulsive patterns are linked to negative outcomes whereas non-impulsive patterns are associated with positive outcomes. Our study aims to serve as a methodological example on how to apply model-based clustering to examine different types of sensation-seeking patterns. This modern clustering method allows for probabilistic categorization, with continous typicality scores besides cluster membership variables. These typicality scores turned out to have higher temporal stability than simple categorical membership variables did.

The predictive validity of the Leonhardean classification of endogenous psychoses: a 21-33-year follow-up of a prospective study ("BUDAPEST 2000").

To our knowledge, no previous long-term studies of the Leonhardean classification in the whole spectrum of endogenous psychoses have been conducted. This prospective study (n = 276; female patients n = 222; normal control persons n = 54) started in 1967–1976. The same population was followed-up by participation of a “blinded control” psychiatrist in 1997–2002 [patients available at follow-up = 125 (56.3%); available controls = 38 (70.4%)]. Patients for this investigation were selected by two independent diagnosticians from eight nosological groups based on full diagnostic agreement. Diagnostic agreement at follow-up (weighted-kappa) was 0.87. Predictive validity of the diagnostic categories was measured empirically and using a stochastic (Markovian) model, thus combining validity and reliability. Hebephrenias, group of normal persons and of schizophrenias proved to be valid categories, with diagnostic stabilities of 0.94, 0.91, and 0.93, for the three groups, respectively. In addition, bipolar manic-depressive psychoses and cycloid psychoses were also valid (diagnostic stability of 0.77 and 0.76, respectively). Unipolar depression was valid (diagnostic stability = 0.84) only by forming a “nosological family” based on diagnostic stability and on current status and clinical presentation during the period preceding the follow-up with regard to other mood-congruent disorders and outcome-diagnosis “normal control”. Validity of systematic paraphrenias (diagnostic stability = 0.69) was in the moderate range. Division of schizophrenias in “systematic versus non-systematic” nosological categories was inconclusive; the categories of affect-laden paraphrenia, periodic catatonia and systematic catatonias could not be confirmed reliably in this study.

Possible effect of gender and season on the length of hospitalisation in unipolar major depressives

BACKGROUND Seasonal variation as well as gender differences of several phenomena of affective disorders are a common topic of interest. METHODS The authors analysed the possible effect of season and gender on the length of hospital stay in 529 in-patients with unipolar major depressive episode. RESULTS Age and menopausal status alone did not influence the length of hospitalisation but there was a statistical tendency (only for females) for the shortest hospital stay in summer, that reached significance in females younger than 50 years. CONCLUSIONS The results suggest a possible seasonal and gender effect on recovery from major depression. LIMITATIONS Retrospective nature of the study, lack of systematic assessment of clinical response and no data collection about marital status and living conditions, that also can influence the time of discharge.