André Dufour

Spatial navigation in normal aging and the prodromal stage of Alzheimer's disease: insights from imaging and behavioral studies.

Normal aging and mild Alzheimers disease (AD) are associated with declines in navigational skills, including allocentric and egocentric representations, cognitive mapping, landmark processing, and spatial memory. These changes, however, are associated with different patterns of structural and functional alterations in the neural network of navigation. In AD, these changes occur in the hippocampus, parahippocampal gyrus, parietal lobe, retrosplenial cortex, prefrontal cortex, and caudate nucleus, whereas in aging, modifications occur mainly in the prefrontal cortex and the hippocampus. The navigation abilities of patients with mild cognitive impairment (MCI) have been found to show different performance patterns, depending on their cognitive profiles. Since patients with MCI do not uniformly develop dementia of the Alzheimer type, it is important to identify reliable early cognitive markers of conversion to AD dementia. In this review, we propose that navigation deficits may help distinguish patients at higher risk of developing AD dementia from individuals with normal cognitive aging and those with other neurodegenerative diseases.

What do we know about aging and spatial cognition? Reviews and perspectives.

In order to cope with normal cognitive aging we must understand the patterns and neurofunctional underpinnings of cognitive and behavioral changes throughout adulthood. In this review, we summarize recent advances in our understanding of age-related behavioral differences and changes in brain structure throughout the spatial domain. Although spatial cognition is critically important to everyday life, few studies have examined the relationship between this cognitive function and neural changes in the aged brain. Thus, spatial cognition is considered a key area in which the cognitive neuroscience of aging may expand in the near future. The first section of this review examines the methodologies and studies used to assess differences in spatial cognition during normal cognitive aging in animals and humans. We then relate how each domain of spatial cognition (e.g., visuospatial perception, mental imagery, memory and navigation) is affected by the aging process, and discuss possible links with changes in neural mechanisms. Lastly, we address putative links among the age-related deterioration patterns of the various spatial domains and make suggestions for future research.

Thermal sensitivity in the elderly: a review.

Aging is associated with a progressive decrease in thermal perception, as revealed by increased thermal detection thresholds in the elderly. This reduction in thermosensitivity follows a distal-proximal pattern, with more pronounced decrements observed in the limbs and in the perception of warmth vs. cold. The main underlying causes of this seem to be aging of the skin and subsequent reductions in thermoreceptor density and superficial skin blood flow. However, the results from some animal studies also suggest that changes in the peripheral nerve system, particularly fiber loss and decreased conduction velocity, may also be involved. In this paper, we review age-related changes in the thermal sensitivity of humans, their underlying mechanisms, and the strengths and limitations of some of the methodologies used to assess these changes.

Theory of Mind in normal ageing and neurodegenerative pathologies.

This paper reviews findings in three subcomponents of social cognition (i.e., Theory of Mind, facial emotion recognition, empathy) during ageing. Changes over time in social cognition were evaluated in normal ageing and in patients with various neurodegenerative pathologies, such as Alzheimers disease, mild cognitive impairment, frontal and temporal variants of frontotemporal lobar degeneration and Parkinsons disease. Findings suggest a decline in social cognition with normal ageing, a decline that is at least partially independent of a more general cognitive or executive decline. The investigation of neurodegenerative pathologies showing specific deficits in Theory of Mind in relation to damage to specific cerebral regions led us to suggest a neural network involved in Theory of Mind processes, namely a fronto-subcortical loop linking the basal ganglia to the regions of the frontal lobes.

Long-lasting effects of performance-contingent unconscious and conscious reward incentives during cued task-switching

Motivation is often thought to interact consciously with executive control, although recent studies have indicated that motivation can also be unconscious. To date, however, the effects of unconscious motivation on high-order executive control functions have not been explored. Only a few studies using subliminal stimuli (i.e., those not related to motivation, such as an arrow to prime a response) have reported short-lived effects on high-order executive control functions. Here, building on research on unconscious motivation, in which a behavior of perseverance is induced to attain a goal, we hypothesized that subliminal motivation can have long-lasting effects on executive control processes. We investigated the impact of unconscious/conscious monetary reward incentives on evoked potentials and neural activity dynamics during cued task-switching performance. Participants performed long runs of task-switching. At the beginning of each run, a reward (50 cents or 1 cent) was displayed, either subliminally or supraliminally. Participants earned the reward contingent upon their correct responses to each trial of the run. A higher percentage of runs was achieved with higher (conscious and unconscious) than lower rewards, indicating that unconscious high rewards have long-lasting behavioral effects. Event-related potential (ERP) results indicated that unconscious and conscious rewards influenced preparatory effort in task preparation, as suggested by a greater fronto-central contingent negative variation (CNV) starting at cue-onset. However, a greater parietal P3 associated with better reaction times (RTs) was observed only under conditions of conscious high reward, suggesting a larger amount of working memory invested during task performance. Together, these results indicate that unconscious and conscious motivations are similar at early stages of task-switching preparation but differ during task performance.

Vigilance and intrinsic maintenance of alert state: An ERP study.

To better understand the involvement of the progressive increase in low-frequency bands in the intrinsic maintenance of the alert state, we assessed the effects of time on the processes expressed in broad-band event-related potentials (ERPs) at play during a test of sustained attention. In this test, the fixed sustained attention to response task (SART) paradigm, a predictable series of single digits are presented (1-9) and subjects are required to make a response to each number (go trials) with the exception of the number 3 (no-go trial). Our results show that vigilance decline, reflected by significant changes in performance and spectral power, is accompanied by specific effects of time on the P2 and Late Positive 1 (LP1) components. The digit 2 is an upcoming cue for the critical target trial, which serves as an important marker for alert response during the task. From this perspective, the amplitude decrease of the P2 (on digit 2 exclusively) with time-on-task could be the concomitant in ERPs of the failures to observe and to attend the critical digit 3. The increase in the amplitude of the later positive component (LP1) from the first period to the last period, could be viewed as a measure of resource allocation, of the higher redeployment of effort towards the task. The progressive deterioration of vigilance level, which results in performance decline and low-frequency activity increase, could thus be a direct consequence of the failure to maintain an intrinsic alert state with time-on-task, despite the larger resource allocation deployed by the participant towards task completion.

Caudate nucleus and social cognition: neuropsychological and SPECT evidence from a patient with focal caudate lesion.

Most studies in social cognition have focused on developmental diseases or analyzed the consequences of acquired frontal lesions on the integrity of Theory of Mind (ToM), but, to our knowledge, none to date has addressed the eventual consequences of damage to the basal ganglia on ToM. To investigate the possible consequences of such lesions on social cognition, we tested a selected patient, MVG, a 44-year-old man with a focal caudate nucleus (CN) lesion following stroke. In the aftermath of this stroke, MVG shows loss of empathy and difficulties recognizing emotions in others. The dual aims of this study were first, to evaluate the implications of CN on ToM and recognition of emotion, and second, to discuss these results as a consequence of a disconnection of the sub-cortical orbito-frontal (OF) loop due to caudate damage. We performed a complete neuropsychological assessment of MVG, as well as different tasks evaluating social cognition, such as the Faux-Pas Test and the Reading the Eyes in the Mind Test. No deficits were found in the neuropsychological tests. However, on tasks assessing social cognition, MVG showed impairments in the warm or affective part of ToM as well as in the ability to recognize negative emotions (i.e., sadness and fear). These results indicate that damage to the head of the left CN can lead to impairment of ToM and emotion recognition. Furthermore, the data shows that, in MVG, such impairment appears to be due to a disconnection of the sub-cortical OF circuit resulting from damage to the CN. Neuro-imaging data tends to confirm this hypothesis by bringing out a hypo-perfusion in both, the territory of his left CN and prefrontal (i.e., ventromedial) brain areas.

Attention and Masking in Schizophrenia

BACKGROUNDnPatients with schizophrenia are known to be impaired in masking tasks, but the mechanisms underlying their deficits are still elusive. Our study was intended to examine attentional effects, which have a known impact on masking in healthy volunteers but have only rarely been explored in relation to masking in patients.nnnMETHODSnWe compared focused versus divided attention in 18 control subjects and 18 patients using forward and backward masking tasks. In the conventional masking task, subjects had to locate one target among four possible locations. Presentation of one target allows attention to be focused, in contrast with the divided attention task in which two targets were presented either in the same hemifield or different hemifields.nnnRESULTSnOur results reproduce patients deficits in forward and backward masking tasks but only when one target is presented. We show that control subjects benefit from focused attention, much more so than patients. Furthermore, patients performance is identical to that of control subjects in backward masking when targets are presented across hemifields. This performance equalization was checked to ensure it was not due solely to the redundancy of signals (two vs. one). We achieved this by comparing performance when two targets were presented in the same vs. across hemifields, the latter yielding a greater redundancy gain.nnnCONCLUSIONSnFrom the results, it is unlikely that redundancy can account for the whole pattern of results, which suggest instead that attention deficits play a role in backward masking impairments in patients.

Brain Lateralization of Metrical Accenting in Musicians

The perception of meter, or the alternation of strong and weak beats, was assessed in musically trained listeners through magnetoencephalography. Metrical accents were examined with no temporal disruption of the serial grouping of tones. Results showed an effect of metrical processing among identical standard tones in the left hemisphere, with larger responses on strong than on weak beats. Moreover, processing of occasional increases in intensity (phenomenal accents) varied as a function of metrical position in the left hemisphere, but not in the right. Our findings support the view of a relatively early, left‐hemispheric effect of metrical processing in musicians.

Very preterm infants can detect small variations in light levels in incubators.

This prospective observational study was designed to improve our understanding of the responses of very preterm infants to light level variations in incubators and to evaluate what determined those reactions.