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Dive into the research topics where Ândrea Kely Campos Ribeiro dos Santos is active.

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Featured researches published by Ândrea Kely Campos Ribeiro dos Santos.


PLOS ONE | 2013

MYC deregulation in gastric cancer and its clinicopathological implications.

Carolina Rosal Teixeira de Souza; Mariana Ferreira Leal; Danielle Queiroz Calcagno; Eliana Kelly Costa Sozinho; Bárbara do Nascimento Borges; Raquel Carvalho Montenegro; Ândrea Kely Campos Ribeiro dos Santos; Sidney Santos; Helem Ferreira Ribeiro; Paulo Pimentel Assumpção; Marília de Arruda Cardoso Smith; Rommel Rodríguez Burbano

Our study investigated the relationship between MYC alterations and clinicopathological features in gastric cancers. We evaluated the effect of MYC mRNA expression and its protein immunoreactivity, as well as copy number variation, promoter DNA methylation, and point mutations, in 125 gastric adenocarcinoma and 67 paried non-neoplastic tissues. We observed that 77% of the tumors presented MYC immunoreactivity which was significantly associated with increased mRNA expression (p<0.05). These observations were associated with deeper tumor extension and the presence of metastasis (p<0.05). MYC protein expression was also more frequently observed in intestinal-type than in diffuse-type tumors (p<0.001). Additionally, MYC mRNA and protein expression were significantly associated with its copy number (p<0.05). The gain of MYC copies was associated with late-onset, intestinal-type, advanced tumor stage, and the presence of distant metastasis (p<0.05). A hypomethylated MYC promoter was detected in 86.4% of tumor samples. MYC hypomethylation was associated with diffuse-type, advanced tumor stage, deeper tumor extension, and the presence of lymph node metastasis (p<0.05). Moreover, eighteen tumor samples presented at least one known mutation. The presence of MYC mutations was associated with diffuse-type tumor (p<0.001). Our results showed that MYC deregulation was mainly associated with poor prognostic features and also reinforced the presence of different pathways involved in intestinal-type and diffuse-type gastric carcinogenesis. Thus, our findings suggest that MYC may be a useful marker for clinical stratification and prognosis.


Forensic Science International-genetics | 2008

A multiplex PCR for 11 X chromosome STR markers and population data from a Brazilian Amazon Region

Elzemar Martins Ribeiro Rodrigues; Fabio Pereira das Neves Leite; Mara H. Hutz; Teresinha de Jesus Brabo Ferreira Palha; Ândrea Kely Campos Ribeiro dos Santos; Sidney Santos

The analysis of X-STR polymorphisms has received the attention of several researchers, mainly due to its applicability to the investigation of complex kinship cases. Although many X-STRs have been validated for forensic use, little is known about the variations of these polymorphisms in different populations of the world. The present work describes a new multiplex system that allows the simultaneous analysis of 11 X-STR markers, for use both in paternity determination and more complex forensic cases. The loci investigated include DXS9895, DXS7132, DXS6800, DXS9898, DXS6789, DXS7133, DXS7130, HPRTB, GATA31E08, DXS7423, and DXS10011, which together afford a power of discrimination in the order of 0.999999. In addition, this work presents the genotyping results obtained for a sample of 324 individuals (182 males and 142 females) from the admixed population of Belém, Pará, located in the Brazilian Amazon Region.


American Journal of Human Biology | 2009

Assessing interethnic admixture using an X‐linked insertion‐deletion multiplex

Elzemar Martins Ribeiro-Rodrigues; Ney Pereira Carneiro dos Santos; Ândrea Kely Campos Ribeiro dos Santos; Rui Pereira; António Amorim; Leonor Gusmão; Marco A. Zago; Sidney Santos

In this study, a PCR multiplex was optimized, allowing the simultaneous analysis of 13 X‐chromosome Insertion/deletion polymorphisms (INDELs). Genetic variation observed in Africans, Europeans, and Native Americans reveals high inter‐population variability. The estimated proportions of X‐chromosomes in an admixed population from the Brazilian Amazon region show a predominant Amerindian contribution (≅41%), followed by European (≅32%) and African (≅27%) contributions. The proportion of Amerindian contribution based on X‐linked data is similar to the expected value based on mtDNA and Y‐chromosome information. The accuracy for assessing interethnic admixture, and the high differentiation between African, European, and Native American populations, demonstrates the suitability of this INDEL set to measure ancestry proportions in three‐hybrid populations, as it is the case of Latin American populations. Am. J. Hum. Biol. 2009.


Epigenomics | 2015

The role of piRNA and its potential clinical implications in cancer

Carolina Baraúna de Assumpção; Danielle Queiroz Calcagno; Taíssa Maíra Thomaz Araújo; Sidney Emmanuel Batista dos Santos; Ândrea Kely Campos Ribeiro dos Santos; Gregory J. Riggins; Rommel Rodríguez Burbano; Paulo Pimentel Assumpção

Epigenetic mechanisms work in an orchestrated fashion to control gene expression in both homeostasis and diseases. Among small noncoding RNAs, piRNAs seem to meet the necessary requirements to be included in this epigenetic network due to their role in both transcriptional and post-transcriptional regulation. piRNAs and PIWI proteins might play important roles in cancer occurrence, prognosis and treatment as reported previously. Nevertheless, the potential clinical relevance of these molecules has yet been elucidated. A brief overview of piRNA biogenesis and their potential roles as part of an epigenetic network that is possibly involved in cancer is provided. Moreover, potential strategies based on the use of piRNAs and PIWI proteins as diagnostic and prognostic biomarkers as well as for cancer therapeutics are discussed.


American Journal of Human Biology | 2010

Estimates of Interethnic Admixture in the Brazilian Population Using a Panel of 24 X-Linked Insertion/Deletion Markers

Rafael Lima Resque; Natalle S.C. Freitas; Elzemar Martins Ribeiro Rodrigues; João Farias Guerreiro; Ney Pereira Carneiro dos Santos; Ândrea Kely Campos Ribeiro dos Santos; Marco A. Zago; Sidney Santos

Objectives. In this study, we aimed to identify ancestry informative haplotypes and make interethnic admixture estimates using X‐chromosome markers.


PLOS ONE | 2014

Distribution of CYP2D6 alleles and phenotypes in the Brazilian population.

Deise C. Friedrich; Júlia Pasqualini Genro; Vinicius de Albuquerque Sortica; Guilherme Suarez-Kurtz; Maria Elizabete de Moraes; Sérgio D.J. Pena; Ândrea Kely Campos Ribeiro dos Santos; Marco Aurélio Romano-Silva; Mara H. Hutz

Abstract The CYP2D6 enzyme is one of the most important members of the cytochrome P450 superfamily. This enzyme metabolizes approximately 25% of currently prescribed medications. The CYP2D6 gene presents a high allele heterogeneity that determines great inter-individual variation. The aim of this study was to evaluate the variability of CYP2D6 alleles, genotypes and predicted phenotypes in Brazilians. Eleven single nucleotide polymorphisms and CYP2D6 duplications/multiplications were genotyped by TaqMan assays in 1020 individuals from North, Northeast, South, and Southeast Brazil. Eighteen CYP2D6 alleles were identified in the Brazilian population. The CYP2D6*1 and CYP2D6*2 alleles were the most frequent and widely distributed in different geographical regions of Brazil. The highest number of CYPD6 alleles observed was six and the frequency of individuals with more than two copies ranged from 6.3% (in Southern Brazil) to 10.2% (Northern Brazil). The analysis of molecular variance showed that CYP2D6 is homogeneously distributed across different Brazilian regions and most of the differences can be attributed to inter-individual differences. The most frequent predicted metabolic status was EM (83.5%). Overall 2.5% and 3.7% of Brazilians were PMs and UMs respectively. Genomic ancestry proportions differ only in the prevalence of intermediate metabolizers. The IM predicted phenotype is associated with a higher proportion of African ancestry and a lower proportion of European ancestry in Brazilians. PM and UM classes did not vary among regions and/or ancestry proportions therefore unique CYP2D6 testing guidelines for Brazilians are possible and could potentially avoid ineffective or adverse events outcomes due to drug prescriptions.


Medicine | 2015

Molecular Analysis of Oral Bacteria in Heart Valve of Patients With Cardiovascular Disease by Real-Time Polymerase Chain Reaction.

Francisco Artur Forte Oliveira; Clarissa Pessoa Fernandes Forte; Paulo Goberlânio de Barros Silva; Camile De Barros Lopes; Raquel Carvalho Montenegro; Ândrea Kely Campos Ribeiro dos Santos; Carlos Roberto Martins Rodrigues Sobrinho; Mário Rogério Lima Mota; Fabrício Bitu Sousa; Ana Paula Negreiros Nunes Alves

AbstractStructural deficiencies and functional abnormalities of heart valves represent an important cause of cardiovascular morbidity and mortality, and a number of diseases, such as aortic stenosis, have been recently associated with infectious agents. This study aimed to analyze oral bacteria in dental plaque, saliva, and cardiac valves of patients with cardiovascular disease. Samples of supragingival plaque, subgingival plaque, saliva, and cardiac valve tissue were collected from 42 patients with heart valve disease. Molecular analysis of Streptococcus mutans, Prevotella intermedia, Porphyromonas gingivalis, and Treponema denticola was performed through real-time PCR. The micro-organism most frequently detected in heart valve samples was the S. mutans (89.3%), followed by P. intermedia (19.1%), P. gingivalis (4.2%), and T. denticola (2.1%). The mean decayed, missing, filled teeth (DMFT) was 26.4 ± 6.9 (mean ± SD), and according to the highest score of periodontal disease observed for each patient, periodontal pockets > 4 mm and dental calculus were detected in 43.4% and 34.7% of patients, respectively. In conclusion, oral bacteria, especially S. mutans, were found in the cardiac valve samples of patients with a high rate of caries and gingivitis/periodontitis.


Genetics and Molecular Biology | 2010

Human aging and somatic point mutations in mtDNA: a comparative study of generational differences (grandparents and grandchildren)

Anderson Nonato do Rosário Marinho; Milene Raiol de Moraes; Sidney Santos; Ândrea Kely Campos Ribeiro dos Santos

The accumulation of somatic mutations in mtDNA is correlated with aging. In this work, we sought to identify somatic mutations in the HVS-1 region (D-loop) of mtDNA that might be associated with aging. For this, we compared 31 grandmothers (mean age: 63 ± 2.3 years) and their 62 grandchildren (mean age: 15 ± 4.1 years), the offspring of their daughters. Direct DNA sequencing showed that mutations absent in the grandchildren were detected in a presumably homoplasmic state in three grandmothers and in a heteroplasmic state in an additional 13 grandmothers; no mutations were detected in the remaining 15 grandmothers. However, cloning followed by DNA sequencing in 12 grandmothers confirmed homoplasia in only one of the three mutations previously considered to be homoplasmic and did not confirm heteroplasmy in three out of nine grandmothers found to be heteroplasmic by direct sequencing. Thus, of 12 grandmothers in whom mtDNA was analyzed by cloning, eight were heteroplasmic for mutations not detected in their grandchildren. In this study, the use of genetically related subjects allowed us to demonstrate the occurrence of age-related (> 60 years old) mutations (homoplasia and heteroplasmy). It is possible that both of these situations (homoplasia and heteroplasmy) were a long-term consequence of mitochondrial oxidative phosphorylation that can lead to the accumulation of mtDNA mutations throughout life.


Forensic Science International-genetics | 2010

Genetic data of twelve X-STRs in a Japanese immigrant population resident in Brazil

Elzemar Martins Ribeiro Rodrigues; Teresinha de Jesus Brabo Ferreira Palha; Ândrea Kely Campos Ribeiro dos Santos; Sidney Santos

In the last years, several works have been published on the variability of X-markers; however, few were on Asian populations. In this work, we present the genetic data of 12 X-STRs (DXS9895, DXS7132, DXS6800, DXS9898, DXS6789, DXS7133, GATA172D05, DXS7130, HPRTB, GATA31E08, DXS7423, DXS10011) obtained from a sample of 232 individuals of Japanese origin residing in Brazil. Most markers investigated present a high genetic diversity, with the exception of DXS6800. No deviations from Hardy-Weinberg equilibrium were observed, with the exception of DXS7133 locus. Linkage disequilibrium analysis did not reveal consistent evidence of association between the X-STRs used. The comparison of the Japanese immigrant population with other Asian populations (Japanese, Chinese, and Korean) demonstrates the inexistence of significant allelic frequency differences between these populations in most systems investigated.


Gastric Cancer | 2016

The adjacent to tumor sample trap.

Paulo Pimentel Assumpção; Sidney Santos; Ândrea Kely Campos Ribeiro dos Santos; Samia Demachki; André Salim Khayat; Geraldo Ishak; Danielle Queiroz Calcagno; Ney Pereira Carneiro dos Santos; Carolina Baraúna de Assumpção; Monica Assumpção; Vinicius Albuquerque Sortica; Taíssa Maíra Thomaz Araújo; Fabiano Cordeiro Moreira; André Mauricio Ribeiro dos Santos; Rommel Rodríguez Burbano

Paulo Pimentel de Assumpcao • Sidney Emanuel Batista dos Santos • Ândrea Kely Campos Ribeiro dos Santos • Samia Demachki • Andre Salim Khayat • Geraldo Ishak • Danielle Queiroz Calcagno • Ney Pereira Carneiro dos Santos • Carolina Barauna de Assumpcao • Monica Barauna de Assumpcao • Vinicius Albuquerque Sortica • Taissa Maira Thomaz Araujo • Fabiano Cordeiro Moreira • Andre Mauricio Ribeiro dos Santos • Rommel Mario Rodriguez Burbano

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Sidney Santos

Federal University of Pará

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Mara H. Hutz

Universidade Federal do Rio Grande do Sul

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Marco A. Zago

University of São Paulo

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