Andréa Mendes do Nascimento
University of São Paulo
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Featured researches published by Andréa Mendes do Nascimento.
Journal of Natural Products | 2008
Miriam H. Kossuga; Andréa Mendes do Nascimento; Juliana Q. Reimão; Andre G. Tempone; Noemi Nosomi Taniwaki; Katyuscya Veloso; Antonio G. Ferreira; Bruno C. Cavalcanti; Cláudia Pessoa; Manoel Odorico de Moraes; Alejandro M. S. Mayer; Eduardo Hajdu; Roberto G. S. Berlinck
Investigation of the bioactive crude extract from the sponge Plakortis angulospiculatus from Brazil led to the isolation of plakortenone ( 1) as a new polyketide, along with five known polyketides ( 2- 6) previously isolated from other Plakortis sponges. The known polyketides were tested in antileishmanial, antitrypanosomal, antineuroinflammatory, and cytotoxicity assays. The results show that plakortide P ( 3) is a potent antiparasitic compound, against both Leishmania chagasi and Trypanosona cruzi, and exhibited antineuroinflammatory activity. The known polyketides 2- 6 were tested for cytotoxicity against four human cancer cell lines, but displayed only moderate cytotoxic activity.
Bioorganic & Medicinal Chemistry | 2009
Myrella Lessio Castro; Andréa Mendes do Nascimento; Masaharu Ikegaki; Claudio M. Costa-Neto; Severino Matias de Alencar; Pedro Luiz Rosalen
A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilian propolis type 6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC(50)=0.1756microM), strong antimicrobial activity (MIC range-0.73-6.6microg/mL; MBC range-2.92-106microg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good.
Food Chemistry | 2016
Tatiane Luiza Cadorin Oldoni; Priscilla Siqueira Melo; Adna Prado Massarioli; Ivani Aparecida M. Moreno; Rosangela Maria Neves Bezerra; Pedro Luiz Rosalen; Gil Valdo José da Silva; Andréa Mendes do Nascimento; Severino Matias de Alencar
Purification and bioassay-guided fractionation were employed to isolate proanthocyanidins with antioxidant activity from peanut skin (Arachis hypogaea Runner 886). The crude extract was prepared with acetone (60% v/v) and purified using chromatographic methods, including a semipreparative HPLC technique. As a result, two proanthocyanidins were isolated and identified using NMR, epicatechin-(2 β → O → 7, 4 β → 8)-catechin (proanthocyanidin A1) and epicatechin-(β → 2 O → 7, 4 β → 8)-epicatechin (proanthocyanidin A2). Despite the structural similarity, differences were observed in their antioxidant activity. Proanthocyanidin A1 proved to be more active, with EC50 value for DPPH radical scavenging of 18.25 μg/mL and reduction of Fe(3+)-TPTZ complex of 7.59 mmol/g, higher than that of synthetic antioxidant BHT. This compound evaluated by ABTS(+) was similar to that of natural quercetin. Therefore, peanut skin is an important source of bioactive compounds that may be used as a mild antioxidant for food preservation.
Química Nova | 2007
Miriam H. Kossuga; Simone P. Lira; Andréa Mendes do Nascimento; Maria Teresa do Prado Gambardella; Roberto G. S. Berlinck; Yohandra Reyes Torres; Gislene G. F. Nascimento; Eli F. Pimenta; Márcio Luis Andrade e Silva; Otavio Henrique Thiemann; Glaucius Oliva; Andre G. Tempone; Marcia de Souza Carvalho Melhem; Ana O. de Souza; Fabio C. S. Galetti; Célio Lopes Silva; Bruno C. Cavalcanti; Cláudia Pessoa; Manoel Odorico de Moraes; Eduardo Hajdu; Solange Peixinho; Rosana Moreira da Rocha
The investigation of extracts from six species of marine invertebrates yielded one new and several known natural products. Isoptilocaulin from the sponge Monanchora aff. arbuscula displayed antimicrobial activity at 1.3 mg/mL against an oxacillin-resistant strain of Staphylococcus aureus. Five inactive known dibromotyrosine derivatives, 2 6, were isolated from a new species of marine sponge, Aplysina sp. The sponges Petromica ciocalyptoides and Topsentia ophiraphidites yielded the known halistanol sulfate A (7) as an inhibitor of the antileishmanial target adenosine phosphoribosyl transferase. The ascidian Didemnum ligulum yielded asterubin (10) and the new N,N-dimethyl-O-methylethanolamine (11). The octocoral Carijoa riisei yielded the known 18-acetoxypregna-1,4,20-trien-3-one (12), which displayed cytotoxic activity against the cancer cell lines SF295, MDA-MB435, HCT8 and HL60.The investigation of extracts from six species of marine invertebrates yielded one new and several known natural products. Isoptilocaulin from the sponge Monanchora aff. arbuscula displayed antimicrobial activity at 1.3 mg/mL against an oxacillin-resistant strain of Staphylococcus aureus. Five inactive known dibromotyrosine derivatives, 2 6, were isolated from a new species of marine sponge, Aplysina sp. The sponges Petromica ciocalyptoides and Topsentia ophiraphidites yielded the known halistanol sulfate A (7) as an inhibitor of the antileishmanial target adenosine phosphoribosyl transferase. The ascidian Didemnum ligulum yielded asterubin (10) and the new N,N-dimethyl-O-methylethanolamine (11). The octocoral Carijoa riisei yielded the known 18-acetoxypregna-1,4,20-trien-3-one (12), which displayed cytotoxic activity against the cancer cell lines SF295, MDA-MB435, HCT8 and HL60.
Journal of Pharmacy and Pharmacology | 2004
Andréa Mendes do Nascimento; Dionéia Camilo Rodrigues de Oliveira; Marcos J. Salvador; Regina Celia Candido; Sérgio de Albuquerque
The dichloromethane extract of underground parts of Calea uniflora (Heliantheae, Asteraceae) exhibited trypanocidal and antifungal activities. Four p‐hydroxyacetophenone derivatives were isolated as the main compounds: 2‐senecioyl‐4‐(hydroxyethyl)‐phenol (1), 2‐senecioyl‐4‐(angeloyloxy‐ethyl)‐phenol (2), and two new derivatives, 2‐senecioyl‐4‐(methoxyethyl)‐phenol (3) and 2‐senecioyl‐4‐(pentadecanoyloxyethyl)‐phenol (4). 1 and 4 were active towards Trypanosoma cruzi trypomastigotes, reducing their number by 70 and 71% at 500 μg mL−1, whereas 2 and 3 were inactive. All the compounds tested showed antifungal activity with minimal inhibitory concentration values between 500 and 1000 μg mL−1 against pathogenic Candida spp. and dermatophytes. The isolation, structure elucidation, NMR spectral assignments and bioactivity results of these compounds are reported.
Journal of the Brazilian Chemical Society | 2001
Andréa Mendes do Nascimento; Dionéia Camilo Rodrigues de Oliveira
Phytochemical study of Mikania stipulacea yielded lupeol, a-amyrin, stigmasterol, b-sitosterol, campesterol, b-sitosteryl glucopyranoside, stigmasteryl glucopyranoside, the coumarin isoscopoletin, and vanillic, cinnamoylgrandifloric and ent-kaurenoic acids, besides two new diterpene acids: ent-9a-hydroxy-15b-E-cinnamoyloxy-16-kauren-19-oic and ent-9a-hydroxy-15b-Z-cinnamoyloxy-16-kauren-19-oic. IR, 1H and 13C NMR and MS spectroscopic analyses were used for the identification of these compounds.
Zeitschrift für Naturforschung C | 2007
Andréa Mendes do Nascimento; Fernanda Cristina Costa; Otavio Henrique Thiemann; Dionéia Camilo Rodrigues de Oliveira
The dichloromethane extract of Calea uniflora afforded a mixture of two novel chromanones, uniflorol-A (1) and uniflorol-B (2), and one known chromanone, 2,2-dimethyl-6- (1-hydroxyethyl)-chroman-4-one (3). The structures of these compounds were determined by spectroscopic methods. Biological activity of the compounds against Leishmania major promastigotes was evaluated. Mixture of the novel chromanones 1 and 2 showed significant growth inhibition of the parasite in the micrograms per milliliter range.
Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy | 2002
Andréa Mendes do Nascimento; Dionéia Camilo Rodrigues de Oliveira; Sérgio de Albuquerque
Dichloromethane crude extract from xylopodium of Calea uniflora Less (Heliantheae-Asteraceae) showed in vitro trypanocidal activity against trypomastigote forms of Trypanosoma cruzi. The data obtained allow to conclude that the crude extract must be investigate to identify its active compounds.
Pharmaceutical Biology | 2007
Juliana Siqueira Chaves; Andréa Mendes do Nascimento; Adriana Pereira Soares; Luciana Mattoso Pires de Campos; Patrícia Abrão de Oliveira; Sérgio de Albuquerque; Dionéia Camilo Rodrigues de Oliveira
Abstract Southeastern Brazilian Mikania. (Asteraceae) species were evaluated for trypanocidal activity against the trypomastigote forms of Trypanosoma cruzi.at a concentration of 4000 µg/mL. Fourteen extracts were examined for in vitro. trypanocidal properties. Of total extracts, 92.9% (13 extracts) exhibited trypanocidal effects. The dichloromethane extract of Mikania camporum. B. Robinson and the methanol extract of Mikania micrantha. H. B. K. caused 100% lysis of the parasites.
Separation and Purification Technology | 2011
Tatiane Luiza Cadorin Oldoni; Ingridy Simone Ribeiro Cabral; Marisa Aparecida Bismara Regitano-d’Arce; Pedro Luiz Rosalen; Masaharu Ikegaki; Andréa Mendes do Nascimento; Severino Matias de Alencar