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Dive into the research topics where Andrea Vukic Dugac is active.

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Featured researches published by Andrea Vukic Dugac.


International Journal of Chronic Obstructive Pulmonary Disease | 2017

Chronic obstructive pulmonary disease with mild airflow limitation: current knowledge and proposal for future research – a consensus document from six scientific societies

Andrea Rossi; Bojana Butorac Petanjek; Marco Chilosi; Borja G. Cosío; Matjaz Flezar; Nickolaos Koulouris; Jose M. Marin; Neven Miculinic; Guido Polese; Miroslav Samaržija; Sabina Škrgat; Theodoros P. Vassilakopoulos; Andrea Vukic Dugac; Spyridon Zakynthinos; Marc Miravitlles

Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and morbidity worldwide, with high and growing prevalence. Its underdiagnosis and hence under-treatment is a general feature across all countries. This is particularly true for the mild or early stages of the disease, when symptoms do not yet interfere with daily living activities and both patients and doctors are likely to underestimate the presence of the disease. A diagnosis of COPD requires spirometry in subjects with a history of exposure to known risk factors and symptoms. Postbronchodilator forced expiratory volume in 1 second (FEV1)/forced vital capacity <0.7 or less than the lower limit of normal confirms the presence of airflow limitation, the severity of which can be measured by FEV1% predicted: stage 1 defines COPD with mild airflow limitation, which means postbronchodilator FEV1 ≥80% predicted. In recent years, an elegant series of studies has shown that “exclusive reliance on spirometry, in patients with mild airflow limitation, may result in underestimation of clinically important physiologic impairment”. In fact, exercise tolerance, diffusing capacity, and gas exchange can be impaired in subjects at a mild stage of airflow limitation. Furthermore, growing evidence indicates that smokers without overt abnormal spirometry have respiratory symptoms and undergo therapy. This is an essential issue in COPD. In fact, on one hand, airflow limitation, even mild, can unduly limit the patient’s physical activity, with deleterious consequences on quality of life and even survival; on the other hand, particularly in younger subjects, mild airflow limitation might coincide with the early stage of the disease. Therefore, we thought that it was worthwhile to analyze further and discuss this stage of “mild COPD”. To this end, representatives of scientific societies from five European countries have met and developed this document to stimulate the attention of the scientific community on COPD with “mild” airflow limitation. The aim of this document is to highlight some key features of this important concept and help the practicing physician to understand better what is behind “mild” COPD. Future research should address two major issues: first, whether mild airflow limitation represents an early stage of COPD and what the mechanisms underlying the evolution to more severe stages of the disease are; and second, not far removed from the first, whether regular treatment should be considered for COPD patients with mild airflow limitation, either to prevent progression of the disease or to encourage and improve physical activity or both.


European Respiratory Journal | 2014

Endothelial dysfunction and systemic inflammation in different COPD phenotypes

Andrea Vukic Dugac; Marko Jakopovic; Sanja Popović-Grle; Blaženka Barišić; Sonja Badovinac; Miroslav Samaržija; Alen Ružić


Journal of Clinical Oncology | 2017

First experience with osimertinib in patients with T790M mutation previously treated with EGFR – TKIs in Croatia.

Marko Jakopovic; Lela Bitar; Branka Cucevic; Sanja Pleština; Ivica Mazuranic; Sven Seiwerth; Ana Hecimovic; Andrea Vukic Dugac; Mateja Jankovic; Gzim Redzepi; Miroslav Samarzija


European Respiratory Journal | 2017

Predictors of invasive mechanical ventilation in patients with acute exacerbation of chronic obstructive pulmonary disease

Gordana Pavlisa; Hrvoje Puretic; Fedja Dzubur; Marina Labor; Andrea Vukic Dugac; Ana Hecimovic; Mateja Jankovic Makek; Marko Jakopovic; Miroslav Samarzija


The Medicus | 2016

Osobitosti pneumonija u bolesnika s kroničnom opstruktivnom plućnom bolesti (KOPB-om)

Andrea Vukic Dugac; Blaženka Barišić


Journal of Clinical Oncology | 2016

The effect of emergency presentation on survival of lung cancer patients.

Marko Jakopovic; Lela Bitar; Ivona Markelić; Fran Seiwerth; Fedza Dzubur; Ana Hecimovic; Branka Cucevic; Ivica Mazuranic; Gzim Redzepi; Andrea Vukic Dugac; Mateja Jankovic Makek; Miroslav Samarzija


European Respiratory Journal | 2016

Endothelial dysfunction and systemic inflammation during acute exacerbations of COPD

Andrea Vukic Dugac; Alen Ruzic; Ana Hecimovic; Mateja Jankovic-Makek; Gordana Pavlisa; Hrvoje Puretic; Gzim Redjepi; Sanja Popović-Grle; Miroslav Samarzija; Marko Jakopovic


European Respiratory Journal | 2015

Flow-mediated dilation of the brachial artery and endothelial dysfunction in different COPD phenotypes

Andrea Vukic Dugac; Alen Ruzic; Sanja Popović-Grle; Ana Hecimovic; Mateja Jankovic Makek; Miroslav Samarzija; Marko Jakopovic


European Respiratory Journal | 2015

Chronic obstructive pulmonary disease and comorbidities

Irena Sokolović; Jelena Knezevic; Sanja Popović-Grle; Andrea Vukic Dugac; Gordana Bubanović; Mateja Jankovic Makek; Ana Hecimovic; Gzim Redzepi; Miroslav Samarzija; Marko Jakopovic


Medix : specijalizirani medicinski dvomjesečnik | 2014

Rano prepoznavanje i dijagnoza kronične opstruktivne plućne bolesti

Andrea Vukic Dugac; Miroslav Samaržija

Collaboration


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Marko Jakopovic

University Hospital Centre Zagreb

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Ana Hecimovic

University Hospital Centre Zagreb

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Miroslav Samarzija

University Hospital Centre Zagreb

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Sanja Popović-Grle

University Hospital Centre Zagreb

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Mateja Jankovic Makek

University Hospital Centre Zagreb

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Miroslav Samaržija

University Hospital Centre Zagreb

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Gzim Redzepi

University Hospital Centre Zagreb

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Blaženka Barišić

University Hospital Centre Zagreb

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Branka Cucevic

University Hospital Centre Zagreb

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