Andreas Mantoulidis

Easy access to the epothilone family-synthesis of epothilone B

Abstract An easy access to four out of five naturally occurring epothilones (A-E, 1–5 ) is reported. Key steps are an enantioselective Mukaiyama type aldol reaction, ( E )- and ( Z )-selective olefinations, and a sulfone alkylation.

Synthesis of the C(11)–C(20) segment of the cytotoxic macrolide epothiline B

Abstract Compound 11, representing the C(11)C(20) segment of the macrolide epothilone B (1b) has been prepared using two Wittig reactions and a Sharpless asymmetric epoxidation as the key steps.