Andrew B. Mahon

Proflavine derivatives as fluorescent imaging agents of amyloid deposits

A series of proflavine derivatives for use to further image Aβ amyloid deposits were synthesized and characterized. Aged 3xTg-AD (23 months old) mice hippocampus sections incubated with these derivatives revealed preferential labeling of amyloid plaques. Furthermore an in vitro binding study showed an inhibitory effect, although moderate, of these compounds on Aβ(40) fibril formation. This study highlights the potential of proflavine as a molecular scaffold for designing new Aβ imaging agents, its native fluorescence allowing in vitro neuropathological staining in AD damaged brain sections.

5,11-Dimethyl­dibenzo[b,f][1,5]diazocine-6,12(5H,11H)-dione

In the molecule of the title compound, C16H14N2O2, an N,N′-dimethyldianthranilide, the two methyl groups are disordered over two positions; site occupation factors were kept fixed as 0.75:0.25 and 0.65:0.35. The dihedral angle between the two benzene rings is 75.57 (3)°.

1,1′-Methylenebis(naphthalen-2-amine) methanol solvate

In the title compound, C21H18N2·CH4O, the two naphthyl ring systems are arranged almost orthogonal to one another, with a dihedral angle of 89.8 (1)°.