Andrew Branson

The Requirements for Ontologies in Medical Data Integration: A Case Study

Evidence-based medicine is critically dependent on three sources of information: a medical knowledge base, the patients medical record and knowledge of available resources, including where appropriate, clinical protocols. Patient data is often scattered in a variety of databases and may, in a distributed model, be held across several disparate repositories. Consequently addressing the needs of an evidence- based medicine community presents issues of biomedical data integration, clinical interpretation and knowledge management. This paper outlines how the Health-e-Child project has approached the challenge of requirements specification for (bio-) medical data integration, from the level of cellular data, through disease to that of patient and population. The approach is illuminated through the requirements elicitation and analysis of Juvenile Idiopathic Arthritis (JIA), one of three diseases being studied in the EC-funded Health- e-Child project.

Medical Data Integration and the Semantic Annotation of Medical Protocols

The integration of heterogeneous biomedical information is one important step towards providing the level of personalization required in the next generation of healthcare provision. In order to provide the computer-based decision support systems needed to access this integrated healthcare information it will be necessary to handle the semantics of (amongst other things) medical protocols. The EC FP6 Health-e-Child project aims to develop an integrated healthcare platform for European paediatrics and decision support tools to access personalized health information. This paper introduces both the integrated data model in the Health-e-Child project and through a case study using the brain tumour protocols it demonstrates the semantic annotation of patient data acquired in the project using UMLS as the primary source of semantic data.

Providing traceability for neuroimaging analyses.

INTRODUCTION With the increasingly digital nature of biomedical data and as the complexity of analyses in medical research increases, the need for accurate information capture, traceability and accessibility has become crucial to medical researchers in the pursuance of their research goals. Grid- or Cloud-based technologies, often based on so-called Service Oriented Architectures (SOA), are increasingly being seen as viable solutions for managing distributed data and algorithms in the bio-medical domain. For neuroscientific analyses, especially those centred on complex image analysis, traceability of processes and datasets is essential but up to now this has not been captured in a manner that facilitates collaborative study. PURPOSE AND METHOD Few examples exist, of deployed medical systems based on Grids that provide the traceability of research data needed to facilitate complex analyses and none have been evaluated in practice. Over the past decade, we have been working with mammographers, paediatricians and neuroscientists in three generations of projects to provide the data management and provenance services now required for 21st century medical research. This paper outlines the finding of a requirements study and a resulting system architecture for the production of services to support neuroscientific studies of biomarkers for Alzheimers disease. RESULTS The paper proposes a software infrastructure and services that provide the foundation for such support. It introduces the use of the CRISTAL software to provide provenance management as one of a number of services delivered on a SOA, deployed to manage neuroimaging projects that have been studying biomarkers for Alzheimers disease. CONCLUSIONS In the neuGRID and N4U projects a Provenance Service has been delivered that captures and reconstructs the workflow information needed to facilitate researchers in conducting neuroimaging analyses. The software enables neuroscientists to track the evolution of workflows and datasets. It also tracks the outcomes of various analyses and provides provenance traceability throughout the lifecycle of their studies. As the Provenance Service has been designed to be generic it can be applied across the medical domain as a reusable tool for supporting medical researchers thus providing communities of researchers for the first time with the necessary tools to conduct widely distributed collaborative programmes of medical analysis.

Provision of an integrated data analysis platform for computational neuroscience experiments

Purpose – The purpose of this paper is to provide an integrated analysis base to facilitate computational neuroscience experiments, following a user-led approach to provide access to the integrated neuroscience data and to enable the analyses demanded by the biomedical research community. Design/methodology/approach – The design and development of the N4U analysis base and related information services addresses the existing research and practical challenges by offering an integrated medical data analysis environment with the necessary building blocks for neuroscientists to optimally exploit neuroscience workflows, large image data sets and algorithms to conduct analyses. Findings – The provision of an integrated e-science environment of computational neuroimaging can enhance the prospects, speed and utility of the data analysis process for neurodegenerative diseases. Originality/value – The N4U analysis base enables conducting biomedical data analyses by indexing and interlinking the neuroimaging and clin...

An Architecture for Semantic Navigation and Reasoning with Patient Data - Experiences of the Health-e-Child Project

Medical ontologies have become the standard means of recording and accessing conceptualized biological and medical knowledge. The expressivity of these ontologies goes from simple concept lists through taxonomies to formal logical theories. In the context of patient information, their application is primarily annotation of medical (instance) data. To exploit higher expressivity, we propose an architecture which allows for reasoning on patient data using OWL DL ontologies. The implementation is carried out as part of the Health-e-Child platform prototype. We discuss the use case where ontologies establish a hierarchical classification of patients which in turn is used to aid the visualization of patient data. We briefly discuss the treemap-based patient viewer which has been evaluated in the Health-e-Child project.

Intelligent grid enabled services for neuroimaging analysis

This paper reports our work in the context of the neuGRID project in the development of intelligent services for a robust and efficient Neuroimaging analysis environment. neuGRID is an EC-funded project driven by the needs of the Alzheimers disease research community that aims to facilitate the collection and archiving of large amounts of imaging data coupled with a set of services and algorithms. By taking Alzheimers disease as an exemplar, the neuGRID project has developed a set of intelligent services and a Grid infrastructure to enable the European neuroscience community to carry out research required for the study of degenerative brain diseases. We have investigated the use of machine learning approaches, especially evolutionary multi-objective meta-heuristics for optimising scientific analysis on distributed infrastructures. The salient features of the services and the functionality of a planning and execution architecture based on an evolutionary multi-objective meta-heuristics to achieve analysis efficiency are presented. We also describe implementation details of the services that will form an intelligent analysis environment and present results on the optimisation that has been achieved as a result of this investigation.

Semantic Matching Using the UMLS

Traditional ontology alignment techniques enable equivalence relationships to be established between concepts in two ontologies with some confidence value. With semantic matching, however, it is possible to identify not only equivalence (***) relationships between concepts, but less general (

Designing Traceability into Big Data Systems

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Health-e-Child: A Grid Platform for European Paediatrics

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Traceability and Provenance in Big Data Medical Systems

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