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Dive into the research topics where Andrew Chan is active.

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Featured researches published by Andrew Chan.


Advances in Experimental Medicine and Biology | 1993

Growth Factors and Malignant Transformation

Stuart A. Aaronson; Toru Miki; Kimberly Meyers; Andrew Chan

In the early 1980’s, approaches aimed at identifying the functions of retroviral oncogenes converged with efforts to investigate normal mitogenic signaling by growth factors. A number of retroviral oncogene products were found to be similar to the protein kinase encoded by v-src product1. Unlike many protein kinases that phosphorylate serine or threonine residues, the v-src product is a protein kinase that specifically phosphorylates tyrosine residues2. Purification and sequencing of growth factors and their receptors revealed that the platelet derived growth factor (PDGF) B-chain is similar to the predicted v-sis oncogene product3 and that the v-erbB oncogene product, which has sequence similarity to the v-src product, is a truncated form of the EGF receptor4. Binding of EGF to its receptor results in autophosphorylation of the receptor on tyrosine5. Oncogenes activated by a variety of mechanisms6 frequently have been shown to encode growth factors, receptor tyrosine kinases or downstream effectors.


Archive | 1992

KGF Receptor: Transforming Potential on Fibroblasts and Epithelial Cell-Specific Expression by Alternative Splicing

Toru Miki; Donald P. Bottaro; Timothy P. Fleming; Cheryl L. Smith; Jeffrey S. Rubin; Andrew Chan; Stuart A. Aaronson

The mouse keratinocyte growth factor (KGF) receptor (KGFR) cDNA was isolated by an expression cDNA cloning strategy involving creation of a transforming autocrine loop. Characterization of the cloned 4.2 kb cDNA revealed a predicted membrane-spanning tyrosine kinase structurally related to the FGF receptor (FGFR). Structural analysis of the human KGFR cloned by the analogous procedure revealed identity with one of the fibroblast growth factor (FGF) receptors (bek/FGFR-2) except for a divergent stretch of 49 amino acids in their extracellular domains. Binding assays demonstrated that the KGFR was a high affinity receptor for both KGF and acidic FGF, while FGFR-2 showed high affinity for basic FGF and acidic FGF but no detectable binding by KGF. Analysis of the bek gene revealed two alternative exons responsible for the region of divergence between the two receptors. The KGFR transcript was specific to epithelial cells, and it appeared to be differentially regulated with respect to the alternative FGFR-2 transcript.


Oncogene | 1992

Met and hepatocyte growth factor/scatter factor signal transduction in normal melanocytes and melanoma cells

Ruth Halaban; Jeffrey S. Rubin; Yoko Funasaka; Melanie H. Cobb; Teri G. Boulton; Donna L. Faletto; Eliot M. Rosen; Andrew Chan; Karen Yoko; Wain L. White; Christopher Cook; Gisela Moellmann


Archive | 2002

Truncated hepatocyte growth factor variants

Andrew Chan; Jeffrey S. Rubin; Donald P. Bottaro; Stuart A. Aaronson; Stephen J. Stahl; Paul T. Wingfield; Vittoria Cioce


Archive | 1995

DNA encoding truncated hepatocyte growth factor variants

Andrew Chan; Jeffrey S. Rubin; Donald P. Bottaro; Stuart A. Aaronson


Archive | 1994

Method of stimulating cell growth with a novel broad spectrum human lung fibroblast-derived mitogen

Jeffrey S. Rubin; Andrew Chan; Stuart A. Aaronson


Archive | 1994

Human ras-related oncogenes unmasked by expression cDNA cloning

Stuart A. Aaronson; Andrew Chan; Toru Miki


Archive | 1998

DNA encoding plasminogen-like growth factor (PLGF) and related embodiments

Jeffrey S. Rubin; Andrew Chan; Stuart A. Aaronson


Archive | 2002

Truncated hepatocyte growth factor variant protein HGF/NK2

Andrew Chan; Jeffrey S. Rubin; Donald P. Bottaro; Stuart A. Aaronson; Stephen J. Stahl; Paul T. Wingfield; Vittoria Cioce


Archive | 2002

NON-MITOGENIC COMPETITIVE HGF ANTAGONIST (HGF/NK1)

Stuart A. Aaronson; Donald P. Bottaro; Andrew Chan; Jeffrey S. Rubin; エー. アーロンソン,スチュアート; エム.エル チャン,アンドルー; ピー. ボッタロ,ドナルド; エス. ラビン,ジェフリー

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Jeffrey S. Rubin

National Institutes of Health

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Donald P. Bottaro

United States Department of Commerce

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Donna L. Faletto

National Institutes of Health

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Toru Miki

National Institutes of Health

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Paul T. Wingfield

National Institutes of Health

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Stephen J. Stahl

National Institutes of Health

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Cheryl L. Smith

National Institutes of Health

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