Andrew D. Blann
Birmingham City Hospital
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Publication
Featured researches published by Andrew D. Blann.
Biological Psychology | 2006
Simon L. Bacon; Christopher Ring; Foo Li Saw Hee; Gregory Y.H. Lip; Andrew D. Blann; Kim L. Lavoie; Douglas Carroll
Episodes of psychological and physical stress may elicit thrombotic cardiac events, such as myocardial infarction. These events are triggered when there are concurrent hemodynamic, hemostatic, and endothelial abnormalities. Hemodynamic, hemostatic, and endothelial reactions of 72 (15 women, 57 men) coronary artery disease patients to psychological and physical stress were examined. Blood pressure, electrocardiography, and impedance cardiography were recorded during rest, mental arithmetic, and exercise. Blood was collected, via catheter, at rest and after each task. Mental arithmetic elicited increases in blood pressure, heart rate, cardiac output, and cardiac contractility, but no consistent changes in hemostatic and endothelial markers. In contrast, exercise, in addition to increasing blood pressure, heart rate, cardiac output, cardiac contractility, and lowering peripheral resistance, elicited increases in plasma viscosity, hematocrit, platelets, and tissue plasminogen activator together with a decrease in plasminogen activator inhibitor. This pattern of hemodynamic, hemostatic, and endothelial reactions suggests that acute psychological and physical stress influence the thrombotic system differently in these high risk patients. Future research is needed to investigate how these stress responses are prospectively related to acute cardiac events.
Journal of the American College of Cardiology | 2016
Yee C. Lau; Marco Proietti; Elisa Guiducci; Andrew D. Blann; Gregory Y.H. Lip
A bidirectional relationship exists between atrial fibrillation (AF) and chronic renal disease. Patients with AF have a higher incidence of renal dysfunction, and the latter predisposes to incident AF. The coexistence of both conditions results in a higher risk for thromboembolic-related adverse events but a paradoxical increased hemorrhagic risk. Oral anticoagulants (both vitamin K antagonists [VKAs] and non-VKA oral anticoagulants [NOACs]) have been demonstrated to be effective inxa0mild to moderate renal dysfunction. Patients with severe renal impairment were excluded from the non-VKA oral anticoagulant trials, so limited data are available. In end-stage renal failure, the net clinical benefit of VKAs in dialysis-dependent patients remains uncertain, although some evidence suggests that such patients may do well with high-quality anticoagulation control. Risk stratification and careful follow-up of such patients are necessary to ensure a net clinical benefit from thromboprophylaxis.
British Journal of Haematology | 2013
Andrew D. Blann
patients with multiple myeloma treated by highdose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant. British Journal of Haematology, 102, 1115–1123. Howells, L.M., Berry, D.P., Elliott, P.J., Jacobson, E.W., Hoffmann, E., Hegarty, B., Brown, K., Steward, W.P. & Gescher, A.J. (2011) Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases–safety, pharmacokinetics, and pharmacodynamics. Cancer Prevention Research (Philadelphia, Pa.), 4, 1419–1425. Jang, M., Cai, L., Udeani, G.O., Slowing, K.V., Thomas, C.F., Beecher, C.W., Fong, H.H., Farnsworth, N.R., Kinghorn, A.D., Mehta, R.G., Moon, R.C. & Pezzuto, J.M. (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science, 275, 218– 220. Jazirehi, A.R. & Bonavida, B. (2004) Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin’s lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis. Molecular Cancer Therapeutics, 3, 71–84. Michishita, E., Park, J.Y., Burneskis, J.M., Barrett, J.C. & Horikawa, I. (2005) Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Molecular Biology of the Cell, 16, 4623–4635. Sirtris Pharmaceuticals, Inc. (2009) SRT501 Investigator’s Brochure Oncology. Sirtris Pharmaceuticals, Inc., Cambridge, MA, USA.
Archive | 2002
Andrew D. Blann; Gregory Y. H. Lip
Archive | 2015
Andrew D. Blann; Gregory Y. H. Lip
/data/revues/00029149/v88i1/S0002914901015971/ | 2011
Andrew D. Blann; David Gurney; Elizabeth Hughes; Peter Buggins; Stanley Silverman; Gregory Y. H. Lip
/data/revues/00029149/v86i2/S0002914900008663/ | 2011
Ira Goldsmith; Andrew D. Blann; Ramesh L. Patel; Gregory Y. H. Lip
Archive | 2010
Foo Leong Li-Saw-Hee; Andrew D. Blann; Gregory Y. H. Lip
Archive | 2010
Gregory Y. H. Lip; Sridhar Kamath; Andrew D. Blann; Graham J. Caine; David Gurney
Archive | 2010
Gregory Y. H. Lip; Dirk C. Felmeden; Charles G.C. Spencer; Andrew D. Blann; D. Gareth Beevers