Andrew J. Toole

Validity of the convergence insufficiency symptom survey: a confirmatory study.

Purpose. The objectives of the present study were to evaluate whether investigator bias influenced the Convergence Insufficiency Symptom Survey (CISS) scores of children with normal binocular vision (NBV) in our original validation study, reevaluate the usefulness of the cutoff score of 16, and reexamine the validity of the CISS. Methods. Six clinical sites participating in the Convergence Insufficiency Treatment Trial (CITT) enrolled 46 children 9 to <18 years with NBV. Examiners masked to the child’s binocular vision status administered the CISS. The mean CISS score was compared with that from the children with NBV in the original, unmasked CISS study and also to that of the 221 symptomatic convergence insufficiency (CI) children enrolled in the CITT. Results. The mean (±standard deviation) CISS score for 46 subjects with NBV was 10.4 (±8.1). This was comparable with our prior unmasked NBV study (mean = 8.1 (±6.2); p = 0.11) but was significantly different from that of the CITT CI group (mean = 29.8 ± 9.0; p < 0.001). Eighty-three percent of these NBV subjects scored <16 on the CISS, which is not statistically different from the 87.5% found in the original unmasked study (p = 0.49). Conclusions. Examiner bias did not affect the CISS scores for subjects with NBV in our prior study. The CISS continues to be a valid instrument for quantifying symptoms in 9 to <18-year-old children. These results also confirm the validity of a cut-point of ≥16 in distinguishing children with symptomatic CI from those with NBV.

The effect of saccades and brief fusional stimuli on phoria adaptation.

Purpose. The purpose of this experiment was to determine whether brief fusional stimuli and saccades similar to those seen in the alternate cover test affect phoria disadaptation. Methods. Three cover test conditions were performed randomly. Before each test condition, subjects fused for 2 min at an angle convergent to the subjective phoria. In one test condition, subjects viewed monocularly. In another condition, subjects alternately fixated with each eye (no binocular time). In a third condition, subjects alternately fixated with each eye, and there was a 100-ms period of binocular viewing between alternations. The ocular vergence angle was monitored using scleral search coils. Results. Vergence angle was plotted against time for each condition. The area under this plot was determined using a computer program. The area reflected the rate at which ocular vergence returned to the original phoria position. The mean area for the monocular condition was 300.9, the mean area for alternate fixation with no binocular time was 300.3, and the mean area for alternate fixation with binocular time was 205.2. Conclusions Saccadic alternations do not affect phoria adaptation. However, short periods in which binocular disparate images are viewed significantly increase the rate at which phoria adaptation declines for some subjects.

The forced vergence cover test and phoria adaptation

Phoria adaptation (PA) provides innervation to help maintain the correct vergence posture for binocularly viewing objects. Once fusion is disrupted, such as is required for measuring a (dissociated) phoria, this innervation is slowly depleted. Thus, extended periods of monocular occlusion can be required to dissipate PA and reveal the full extent of the phoria. Two versions of a forced vergence modification of the alternating cover test (CT) have been proposed to rapidly show the full phoria. We evaluated the ability of these forced vergence CTs (FVCT‐1 and FVCT‐2) to deplete the PA induced by a 15 min adaptation period to base out prism. In both experiments, the CT followed by the FVCT was performed before and after the adaptation period. In Experiment 1 (n = 13), the FVCT‐1 was evaluated at 40 cm. Experiment 2 (n = 32) evaluated the FVCT‐2 at 4 m. In Experiments 1 and 2, the difference between pre‐ and post‐adaptation CTs showed significant PA occurred during the adaptation period (7.8Δ, p < 0.0005, and 5.4Δ, p < 0.0005 respectively). In Experiment 1, the FVCT‐1 did not reveal a larger phoria than the CT before (mean difference: 0.4Δ, p = 0.34) or after (no difference for all subjects) the adaptation period. Thus, the FVCT‐1 did not alter PA. In Experiment 2, the FVCT‐2 did show a shift in the phoria compared to the CT. However, this shift was found to be equivalent before and after the adaptation period (mean difference in shift: 0.22Δ, 95% CI: −0.52 to 0.96Δ). Thus, the FVCT‐2 shifts the phoria a constant amount independent of the amount of PA present. We conclude that neither FVCTs behaviour is dependent on the PA present. Thus, these procedures are unlikely to be effective clinical procedures for revealing the full magnitude of the phoria.

Visual Function of Moderately Hyperopic 4- and 5-Year-Old Children in the Vision in Preschoolers - Hyperopia in Preschoolers Study.

PURPOSE To compare visual performance between emmetropic and uncorrected moderately hyperopic preschool-age children without strabismus or amblyopia. DESIGN Cross-sectional study. METHODS setting: Multicenter, institutional. patient or study population: Children aged 4 or 5 years. intervention or observation procedures: Visual functions were classified as normal or reduced for each child based on the 95% confidence interval for emmetropic individuals. Hyperopic (≥3.0 diopters [D] to ≤6.0 D in the most hyperopic meridian; astigmatism ≤1.50 D; anisometropia ≤1.0 D) and emmetropic status were determined by cycloplegic autorefraction. MAIN OUTCOME MEASURES Uncorrected monocular distance and binocular near visual acuity (VA); accommodative response; and near random dot stereoacuity. RESULTS Mean (± standard deviation) logMAR distance visual acuity (VA) among 248 emmetropic children was better than among 244 hyperopic children for the better (0.05 ± 0.10 vs 0.14 ± 0.11, P < .001) and worse eyes (0.10 ± 0.11 vs 0.19 ± 0.10, P < .001). Mean binocular logMAR near VA was better in emmetropic than in hyperopic children (0.13 ± 0.11 vs 0.21 ± 0.11, P < .001). Mean accommodative response for emmetropic children was lower than for hyperopic subjects for both Monocular Estimation Method (1.03 ± 0.51 D vs 2.03 ± 1.03 D, P < .001) and Grand Seiko (0.46 ± 0.45 D vs 0.99 ± 1.0 D, P < .001). Median near stereoacuity was better in emmetropic than in than hyperopic children (40 sec arc vs 120 sec arc, P < .001). The average number of reduced visual functions was lower in emmetropic than in hyperopic children (0.19 vs 1.0, P < .001). CONCLUSIONS VA, accommodative response, and stereoacuity were significantly reduced in moderate uncorrected hyperopic preschool children compared to emmetropic subjects. Those with higher hyperopia (≥4 D to ≤6 D) were at greatest risk, although more than half of children with lower magnitudes (≥3 D to <4 D) demonstrated 1 or more reductions in function.

A review of proximal inputs to the near response.

Maddox proposed that the perceived nearness of a target could influence the ocular vergence response. Proximal inputs have been used to refer to all static and dynamic cues to depth other than disparity and blur. In this paper, we review a number of studies in which proximal influences have been assessed. While general agreement exists that proximal contributions are significant when blur and disparity cues are absent (open‐loop conditions), there are conflicting reports on the role of proximal vergence and accommodation under closed‐loop conditions.

Evaluation of single pixel step sizes in visual acuity assessment.

Purpose. Adaptive thresholding procedures (e.g., ZEST) benefit from testing near the current estimate of threshold. Therefore, small increments may improve precision of these techniques. We evaluated the validity of visual acuity assessment when letters are not constrained to a multiple of 5 pixels high. Methods. Snellen letters were presented over a ±5 pixel range spanning the final threshold estimate. Sizes that were a multiple of 5 pixels (e.g., 20 and 25) were presented 160 times, and other sizes were presented 40 times. This resulted in 320 letter presentations at multiples of 5 and at non-multiples of 5. Post hoc ZEST procedures were used to compute acuity threshold estimates based on testing at those two sets of sizes. Two subjects participated: subject 1 for the right and left eyes and subject 2 in two sessions with binocular viewing. Psychometric functions were fit to the data and were used to model simulated observers. Simulations were run for each data set, and the number of presentations at each size matched the number presented to the subject. Ninety percent limits for proportion correct at each letter size were determined from the simulation data, and these limits were used as criteria for identifying outliers in the subjects data. Results. No significant difference in acuity thresholds were found when letters were rendered in multiples of 5 pixel heights vs. letters without this constraint. Empirical data fell within the bounds defined by simulations, with no idiosyncratic results found for either set of letter sizes. Conclusions. Letter sizes that do not conform to a multiple of 5 pixel letter height yield valid acuity scores. This facilitates adaptive psychometric procedures for acuity testing, such as ZEST and QUEST, in which letter sizes are selected to be as close to the current estimate of threshold size as possible.

Screening for convergence insufficiency in school-age children: Convergence insufficiency in children

Convergence insufficiency (CI) is a common binocular vision disorder which often causes symptoms when doing near work. However, the best screening test for CI is unknown. The purpose of this study was to evaluate the ability of common tests of binocular and accommodative function to identify children with CI in a school screening setting.