Andrew Liu

Perturbation of CD4+ and CD8+ T-Cell Repertoires DuringProgression to AIDS and Regulation of the CD4+ Repertoire DuringAntiviral Therapy

1. Gorochov G, 2. Neumann AU, 3. Kereveur A, 4. et al. (1998) Nature Med. 4:215–221. [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] #### Purpose of the Study To study the diversity of the T lymphocyte repertoire during the course of human immunodeficiency virus (HIV)-1 infection and after combination antiretroviral therapy. ##### Study Population Eleven HIV-infected adults undergoing triple antiviral therapy were compared with 7 untreated HIV-infected adults and 5 noninfected controls. ##### Methods Assessment of T-cell antigen receptor (TCR) repertoire in CD4+ and CD8+ T cells by TCR sequence analysis. ##### Results In nontreated HIV-infected subjects, CD8+ T cell TCR repertoire … [1]: {openurl}?query=rft.jtitle%253DNature%2Bmedicine%26rft.stitle%253DNat%2BMed%26rft.aulast%253DGorochov%26rft.auinit1%253DG.%26rft.volume%253D4%26rft.issue%253D2%26rft.spage%253D215%26rft.epage%253D221%26rft.atitle%253DPerturbation%2Bof%2BCD4%252B%2Band%2BCD8%252B%2BT-cell%2Brepertoires%2Bduring%2Bprogression%2Bto%2BAIDS%2Band%2Bregulation%2Bof%2Bthe%2BCD4%252B%2Brepertoire%2Bduring%2Bantiviral%2Btherapy.%26rft_id%253Dinfo%253Adoi%252F10.1038%252Fnm0298-215%26rft_id%253Dinfo%253Apmid%252F9461196%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1038/nm0298-215&link_type=DOI [3]: /lookup/external-ref?access_num=9461196&link_type=MED&atom=%2Fpediatrics%2F104%2FSupplement_2%2F400.2.atom [4]: /lookup/external-ref?access_num=000072249800038&link_type=ISI