Andrew McCombie

Psychotherapy for inflammatory bowel disease: A review and update

BACKGROUND Psychotherapy may be a useful intervention for inflammatory bowel disease (IBD) patients. We systematically reviewed all randomized controlled trials that have been performed in psychotherapy for inflammatory bowel disease patients. METHODS Systematic searches were undertaken on 1 and 8 March, 2012 of studies of psychotherapy for IBD. RESULTS Eighteen studies (19 papers) were included in this review. Psychotherapy was found to have minimal effect on measures of anxiety, depression, QOL and disease progression although shows promise in reducing pain, fatigue, relapse rate and hospitalisation, and improving medication adherence. It may also be cost effective. CONCLUSIONS The effects of psychotherapy on IBD is mixed: future studies should determine whether patient screening or measuring different dependent variables improves outcomes and whether particular psychotherapies are superior over others.

How IBD patients cope with IBD: A systematic review

OBJECTIVE Inflammatory bowel disease (IBD) can have a significant impact on psychological wellbeing and quality of life. How one responds to and copes with IBD may be an important determinant of psychological wellbeing. We aimed to systematically review all published literature regarding coping strategies of IBD patients. METHODS Ovid and Pubmed databases were searched over 6 months. All articles about coping strategies of IBD patients were included. RESULTS Thirty-nine articles using twenty-two survey instruments were found, of which twenty-six were adult exclusive, eleven were children exclusive, and two had both adults and children. Two were interventional, four were longitudinal, and the rest were cross-sectional studies. Four studies were qualitative while the rest used quantitative measures. Variance in research designs and coping instruments led to inconsistent results. The most common theme was that emotion-focused coping was associated with worse psychological outcomes, while the effect of problem-focused coping was less consistently associated with better psychological outcomes. CONCLUSIONS More longitudinal and interventional studies are needed to causally link coping strategies with psychological outcomes in IBD patients.

Does computerized cognitive behavioral therapy help people with inflammatory bowel disease? A randomized controlled trial

Background:Cognitive behavioral therapy may be useful for improving health-related quality of life (HRQOL) of at least some patients with inflammatory bowel disease (IBD), especially those with psychiatric comorbidities. However, cognitive behavioral therapy can be difficult to access. These difficulties can be overcome by computerized cognitive behavioral therapy (CCBT). This is a randomized controlled trial of a self-administered CCBT intervention for patients with IBD focused on improving HRQOL. It is hypothesized that CCBT completers will have an improved HRQOL relative to people not allocated to CCBT. Methods:Patients with IBD were randomly allocated to CCBT (n = 113) versus treatment as usual (n = 86). The IBD Questionnaire at 12 weeks after baseline was the primary outcome, while generic HRQOL, anxiety, depression, coping strategies, perceived stress, and IBD symptoms were secondary outcomes. Outcomes were also measured at 6 months after baseline. Predictors of dropout were also determined. Results:Twenty-nine CCBT participants (25.7%) completed the CCBT. The IBD Questionnaire was significantly increased at 12 weeks in CCBT completers compared with treatment-as-usual patients (F = 6.38, P = 0.01). Short Form-12 mental score (F = 5.00, P = 0.03) was also significantly better in CCBT compared with treatment-as-usual patients at 12 weeks. These outcomes were not maintained at 6 months. The predictors of dropout were baseline depression, biological use, lower IBD Questionnaire scores, and not having steroids. Conclusions:Improvements at 12 weeks after baseline were not maintained at 6 months. Future research should aim to improve adherence rates. Moreover, CCBT may not work for patients with IBD with comorbid depression.

Computerised Cognitive Behavioural Therapy for Psychological Distress in Patients with Physical Illnesses: A Systematic Review

Whilst cognitive behaviour therapy (CBT) has been shown to improve outcomes in patients with chronic physical illnesses, there are barriers to its implementation which computerised CBT (CCBT) may overcome. We reviewed all studies of CCBT for treating psychological distress (PD) in chronic physical illness populations. Systematic searches were undertaken in July, 2013. All articles about CCBT for PD secondary to physical illness were included. Twenty-nine studies (thirty papers) were included. Overall, the quality of evidence was poor. Studies about irritable bowel syndrome demonstrated the best evidence. The evidence for CCBT in the treatment of PD in physical illness patients is modest, perhaps due to the seldom use of PD screening. More robust research designs including longer follow up periods are required. Nevertheless, no studies reported a negative effect of CCBT on any outcome measures.

Coping Strategies and Psychological Outcomes of Patients with Inflammatory Bowel Disease in the First 6 Months After Diagnosis.

Background:Inflammatory bowel disease (IBD) is associated with reduced physical and mental well-being. The first 6 months after diagnosis is an important time in a patients life with IBD. On top of the physical symptoms, psychological characteristics, such as coping strategies and personality, may contribute to impaired or improved health-related quality of life (HRQOL), anxiety, and depression. This study aimed to measure the stability of coping strategies and personality over the first 6 months after diagnosis and identify the associations of coping strategies and personality traits with the level of HRQOL and degree of anxiety and depression. This study aimed to measure HRQOL, anxiety, depression, IBD symptoms, coping, and personality at baseline and 6 months. Methods:Questionnaires about HRQOL, anxiety, depression, IBD symptoms, coping, personality, and demographic information were administered to patients at baseline and 6 months after diagnosis. Results:Personality characteristics were stable over the first 6 months but coping strategies were not. Maladaptive coping strategies were associated with worse outcomes but adaptive coping strategies were not associated with better outcomes. All measures of HRQOL improved. Neuroticism was associated with worse psychological anxiety, depression, and HRQOL outcomes. Conclusions:This is the first study to psychologically test patients with IBD during the first 6 months after diagnosis. Generally, the HRQOL of patients with IBD improves over this time. Maladaptive coping is associated with worse psychological anxiety, depression, and HRQOL physical outcomes; although until an interventional study is performed, reverse causation cannot be ruled out.

Preferences of inflammatory bowel disease patients for computerised versus face-to-face psychological interventions

BACKGROUND AND AIMS Psychological interventions can be effective treatments for patients with medical illnesses such as inflammatory bowel disease (IBD). However, there are barriers to their widespread implementation such as lack of therapists, high costs, stigma, and poor accessibility in remote areas. Computerised psychological interventions can overcome these barriers. The aim of this study was to measure and compare the preferences of IBD patients for computerised versus face-to-face psychological interventions. METHODS One hundred and two IBD patients were given a support willingness questionnaire which measured their willingness and confidence to participate in computerised and face-to-face psychological interventions as well as the number of sessions they would be willing to participate in. RESULTS IBD patients were more likely to want to take part in a computer based than face-to-face intervention (45.5% versus 16.8%, p=0.045). Furthermore, IBD patients were willing to participate in more sessions of computerised than face-to-face intervention median (5 vs. 3.5, Z=3.93, p<0.001). Younger females had a significantly higher acceptability of a computerised intervention than older females (χ(2)(1)=6.77, p=0.009) but the same was not found for males. Duration of disease was not associated with willingness to participate in an intervention. CONCLUSIONS IBD patients appear more willing to participate in a computerised than face-to face psychological intervention. Future studies should attempt to study the effectiveness of computerised psychological interventions in IBD.

Early postoperative complications have long-term impact on quality of life after restorative proctocolectomy.

IntroductionEarly postoperative complications graded according to the Clavien–Dindo classification system have not previously been correlated with long-term quality of life outcomes in patients who have had restorative proctocolectomy with ileal pouch-anal anastomosis. This study aimed to assess the severity of early postoperative complications and compared these in terms of the long-term quality of life after restorative proctocolectomy in a population-based cohort of patients (operated on from 1984 to 2013). It was hypothesized that those who experienced grade 3 or 4 Clavien–Dindo complications would have worse quality of life at follow-up. MethodsThis population-based study used a combination of a retrospective note review and a cross-sectional questionnaire. All patients with a restorative proctocolectomy performed in 1984–2013 in the Canterbury region were recruited using multiple sources. Early (⩽30 days) and late (>30 days) complication rates were obtained via patient records. Early postoperative complications were graded according to the Clavien–Dindo classification. Quality of life was measured using the inflammatory bowel disease questionnaire. ResultsOne hundred and thirty-six people were identified with a median follow-up of 12 years. Data were available for 121 patients for early complications and 112 for late complications. Eighty-one eligible participants had their quality of life assessed (86% response rate). Early complications occurred in 26% and 76% had late complications. Those who had Clavien–Dindo grade 3 or 4 early complications had lower quality of life scores (P = 0.001) as did females (P = 0.004) and those with a stricture (P = 0.031). ConclusionThis population-based study with long-term follow-up demonstrates that Clavien–Dindo grade 3 and 4 postoperative complications are important in determining quality of life in the long term. The reduction in these complications should be a focus of patient management, as it should improve long-term quality of life.

Observational Study of Perspectives of Inflammatory Bowel Disease Patients Concerning the Use of Corticosteroids

Aim: We aimed to investigate the factors that make inflammatory bowel disease (IBD) patients more or less likely to be willing to take corticosteroids. Methods: Respondents completed a questionnaire. The primary outcome was whether the respondents would or would not use corticosteroids again to treat their IBD. Three separate univariate and multivariate analyses were performed to examine which variables predicted willingness to take steroids, including specific side effects. Results: Four hundred fifty three respondents (321 with Crohns disease, 115 with ulcerative colitis; mean age 40 years, 297 [66%] female) completed the questionnaire. Corticosteroid efficacy (OR 6.83, 95% CI 3.67-12.7), lack of previous negative side effects (OR 0.11, 95% CI 0.04-0.32), and positive side effects (OR 2.96, 95% CI 1.63-5.40) were associated with a willingness to use corticosteroids in the future. In multivariate analysis, weight gain (OR 0.53, 95% CI 0.29-0.98) and hallucinations (OR 0.28, CI 0.09-0.89) were associated with an unwillingness to use corticosteroids again, whereas increased energy (OR 2.30, 95% CI 1.20-4.42) was the only significant positive side effect in a multivariate model. Conclusions: Past experiences with corticosteroids influence whether patients will take corticosteroids again. Clinicians should enquire about side effects and positive psychological symptoms associated with corticosteroid use.