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Featured researches published by Andrew Michael Ratz.


Tetrahedron Letters | 1999

SNAR REACTIONS OF 2-HALOARYLSULFOXIDES WITH ALKOXIDES PROVIDE A NOVEL SYNTHESIS OF THIOTOMOXETINE

Andrew Michael Ratz; Leland Otto Weigel

Abstract A five step synthesis of thiotomoxetine ( 2 ) is described. Installation of the aryl ether was accomplished using a highly efficient S N Ar fragment coupling between amino alcohol ( 4 ) and a 1-halo-2-methylsulfinylbenzene (X = F or Cl) followed by a selective reduction of the arylsulfoxide moiety.


Journal of Organic Chemistry | 2001

Synthesis of novel retinoid X receptor-selective retinoids.

Margaret M. Faul; Andrew Michael Ratz; Kevin A. Sullivan; William George Trankle; Leonard L. Winneroski


Journal of Medicinal Chemistry | 2000

1,2-Dibenzamidobenzene inhibitors of human factor Xa

David K. Herron; Theodore Goodson; Michael Robert Wiley; Leonard C. Weir; Kyle Ja; Ying Kwong Yee; Anne Louise Tebbe; Jennifer M. Tinsley; David Mendel; John Joseph Masters; Jeffry Bernard Franciskovich; Sawyer Js; Douglas Wade Beight; Andrew Michael Ratz; Guy Milot; Valentine J. Klimkowski; James H. Wikel; Eastwood Bj; Richard D. Towner; Donetta S. Gifford-Moore; Trelia J. Craft; Gerald F. Smith


Journal of Medicinal Chemistry | 2000

Structure-based design of potent, amidine-derived inhibitors of factor Xa: evaluation of selectivity, anticoagulant activity, and antithrombotic activity.

Michael Robert Wiley; Leonard C. Weir; Steven L. Briggs; Nancy A. Bryan; John A. Buben; Charles S. Campbell; Nickolay Y. Chirgadze; Richard C. Conrad; Trelia J. Craft; James Ficorilli; Jeffry Bernard Franciskovich; Larry L. Froelich; Donetta S. Gifford-Moore; Theodore Goodson; David K. Herron; Valentine J. Klimkowski; Kenneth D. Kurz; Jeffery A. Kyle; John Joseph Masters; Andrew Michael Ratz; Guy Milot; Robert Theodore Shuman; Tommy Smith; Gerald F. Smith; Ann Louise Tebbe; Jennifer M. Tinsley; Richard D. Towner; and Alexander Wilson; Ying K. Yee


Journal of Medicinal Chemistry | 2000

Non-amidine-containing 1,2-dibenzamidobenzene inhibitors of human factor Xa with potent anticoagulant and antithrombotic activity.

John Joseph Masters; Jeffry Bernard Franciskovich; Jennifer M. Tinsley; Charles S. Campbell; Jack B. Campbell; Trelia J. Craft; Larry L. Froelich; Donetta S. Gifford-Moore; Lynne A. Hay; David K. Herron; Valentine J. Klimkowski; Kenneth D. Kurz; James T. Metz; Andrew Michael Ratz; Robert Theodore Shuman; Gerald F. Smith; Tommy Smith; Richard D. Towner; Michael Robert Wiley; Alexander Wilson; Ying K. Yee


Journal of Organic Chemistry | 1992

Solid-state and solution conformational analysis of tartrate-derived 1,3-dioxolanes and 1,3,2-dioxaborolanes

William R. Roush; Andrew Michael Ratz; Jill A. Jablonowski


Bioorganic & Medicinal Chemistry Letters | 2007

Anthranilamide inhibitors of factor Xa

David Mendel; Angela Lynn Marquart; Sajan Joseph; Philip Parker Waid; Ying K. Yee; Anne Louise Tebbe; Andrew Michael Ratz; David K. Herron; Theodore Goodson; John Joseph Masters; Jeffry Bernard Franciskovich; Jennifer M. Tinsley; Michael Robert Wiley; Leonard C. Weir; Jeffrey Alan Kyle; Valentine J. Klimkowski; Gerald F. Smith; Richard D. Towner; Larry L. Froelich; John A. Buben; Trelia J. Craft


Archive | 1998

Process to make chiral compounds

Andrew Michael Ratz


Archive | 2000

Stereospecific method for preparing tomoxetine and intermediates thereof

Perry Clark Heath; Andrew Michael Ratz; Leland Otto Weigel


Archive | 2005

AROMATIC ETHER DERIVATIVES USEFUL AS THROMBIN INHIBITORS

Ankush Baburao Argade; Theodore Goodson; David K. Herron; Sajan Joseph; Salvatore D. Lepore; Angela Lynn Marquart; John Joseph Masters; David Mendel; Leander Merritt; Andrew Michael Ratz; Gerald F. Smith; Anne Louise Tebbe; Michael Robert Wiley; Ying Kwong Yee

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