Andrew Montoure

Long-term functional outcomes and predictors of shunt-dependent hydrocephalus after treatment of ruptured intracranial aneurysms in the BRAT trial: revisiting the clip vs coil debate.

BACKGROUND Acute hydrocephalus is a well-known sequela of aneurysmal subarachnoid hemorrhage (SAH). Controversy exists about whether open microsurgical methods serve to reduce shunt dependency compared with endovascular techniques. OBJECTIVE To determine predictors of shunt-dependent hydrocephalus and functional outcomes after aneurysmal SAH. METHODS A total of 471 patients who were part of a prospective, randomized, controlled trial from 2003 to 2007 were retrospectively reviewed. All variables including demographic data, medical history, treatment, imaging, and functional outcomes were included as part of the trial. No additional variables were retrospectively collected. RESULTS Ultimately, 147 patients (31.2%) required a ventriculoperitoneal shunt (VPS) in our series. Age, dissecting aneurysm type, ruptured vertebrobasilar aneurysm, Fisher grade, Hunt and Hess grade, admission intraventricular hemorrhage, admission intraparenchymal hemorrhage, blood in the fourth ventricle on admission, perioperative ventriculostomy, and hemicraniectomy were significant risk factors (P < .05) associated with shunt-dependent hydrocephalus on univariate analysis. On multivariate analysis, intraventricular hemorrhage and intraparenchymal hemorrhage were independent risk factors for shunt dependency (P < .05). Clipping vs coiling treatment was not statistically associated with VPS after SAH on both univariate and multivariate analyses. Patients who did not receive a VPS at discharge had higher Glasgow Outcome Scale and Barthel Index scores and were more likely to be functionally independent and to return to work 72 months after surgery (P < .05). CONCLUSION There is no difference in shunt dependency after SAH among patients treated by endovascular or microsurgical means. Patients in whom shunt-dependent hydrocephalus does not develop after SAH tend to have improved long-term functional outcomes.

Acid ceramidase is a novel drug target for pediatric brain tumors

Pediatric brain tumors are the most common solid tumors in children and are also a leading culprit of cancer-related fatalities in children. Pediatric brain tumors remain hard to treat. In this study, we demonstrated that medulloblastoma, pediatric glioblastoma, and atypical teratoid rhabdoid tumors express significant levels of acid ceramidase, where levels are highest in the radioresistant tumors, suggesting that acid ceramidase may confer radioresistance. More importantly, we also showed that acid ceramidase inhibitors are highly effective at targeting these pediatric brain tumors with low IC50 values (4.6–50 μM). This data suggests acid ceramidase as a novel drug target for adjuvant pediatric brain tumor therapies. Of these acid ceramidase inhibitors, carmofur has seen clinical use in Japan since 1981 for colorectal cancers and is a promising drug to undergo further animal studies and subsequently a clinical trial as a treatment for pediatric patients with brain tumors.

Management of Adult Traumatic Brain Injury: A Review

Traumatic brain injury (TBI) is a significant source of morbidity and mortality in the adult population. The management of traumatic brain injury depends on its severity. It must be recognized that almost all forms of treatment for TBI are geared towards the minimization of secondary injury, as it is assumed that primary injury is irreversible. The discussion here represents much of what is known up-to-date concerning TBI management, but its treatment continues to evolve once new mechanisms of injury are discovered and those that we know of now are refined. The treating staffs are encouraged to keep up with the current state of the literature to stay informed.

A rare remarkable recovery in a pediatric patient with the bi-hemispheric, transventricular trajectory craniocerebral gunshot wound.

The gunshot wound to the head (GSWH) is associated with a mortality rate of 20–90% in adults and 20–65% in the pediatric population. Due to the high rates of mortality and morbidity, the management of these patients has been a topic of high interest in the neurosurgical community. We present an 18-year-old male suffering a GSWH with the bullet following a transventricular trajectory and crossing the midsagittal plane, creating extensive intracranial injuries. Despite a calculated mortality rate of >97% from these devastating injuries, the patient survived the GSWH and made a remarkable recovery. The young adult brain still maintains a high potential for neurological plasticity. This may partially explain why the young adult population with a severe GSWH can have a better than expected recovery course. Bifrontal GSW injuries may have much better outcomes than more posterior injuries as has been demonstrated in this patient in this case.

A rare extra-axial midline tentorial adult medulloblastoma with dural-tail sign mimicking a meningioma

Medulloblastomas are categorized as the World Health Organization Grade IV neoplasms. Only 33 cases have been reported of extra-axial, mostly in the cerebellar pontine angle and lateral cerebellar hemisphere, medulloblastomas in the current literature. Our study showcases the first case of an extremely rare presentation of an extra-axial midline tentorial adult medulloblastoma with the dural-tail sign mimicking a meningioma. To achieve the best possible outcome, a high index of suspicion for medulloblastoma is critical especially in young patient with an atypical posterior fossa mass as treatment regimens drastically different between a medulloblastoma and a meningioma.

A novel application of the integra camino bolt for the drainage of chronic subdural hematoma: A technical note

Background: Chronic subdural hematoma (cSDH) is a common neurosurgical pathology associated with older age and complicated by antiplatelet/anticoagulant therapies. With improving medical care in an aging population, the incidence of cSDH will likely increase over the next 25 years, placing a burden on health care costs. Aims: A simple and inexpensive treatment option for cSDH is desirable. Material and methods: We report a basic, but novel, technique to drain cSDH with an Integra Camino bolt. Results: This technique was employed in two patients, where the significant resolution of cSDH and associated clinical symptoms were observed without complications. Conclusions: Our technique is simple and effective. It incorporates readily available materials, which reduces costs. Such characteristics are necessary, given the increasing incidence of cSDH.

Surgical Management of Chronic Subdural Hematoma: Short Communication

Chronic subdural hematoma (cSDH) is a common neurosurgical pathology associated with prior traumatic brain injury (TBI) and older age that is often complicated by antiplatelet or anticoagulant therapies. cSDH often results from the liquefaction of a previous acute subdural hematoma that accompanies TBI. The incidence of cSDH will likely increase over the next 25 years, placing a burden on health care costs. As such, a simple, inexpensive treatment option is desirable. In this short communication, we describe recent data and different techniques that are available for treating cSDH.

Biomechanics and Management of Lumbar Spinal Stenosis NeurodegenerativeDisease: Mini-Review

Lumbar stenosis is an increasingly common pathology, which causes significant symptoms affecting quality of life, especially in the aging population. The mainstays of treatment employ both conservative and surgical management. Should surgery be required decompression of the lumbar spine via laminectomy or laminotomy has been shown to be effective. The addition of fusion may only benefit in cases with spinal instability. The treatment of lumbar stenosis should include a multifactorial and multidisciplinary approach. Lumbar fusion may lead to an adjacent segment disease as a result of endplate failure by promoting a lumbar alignment with parallel endplates. Upright MRI could be a useful adjunct objective diagnostic option in the future to differentiate symptomatic from asymptomatic patients by evaluating their foraminal geometry.

Radiation Necrosis Secondary to Trigeminal Nerve TomoTherapy: A Cautionary Case Study

New radiation delivery modalities have recently challenged Gamma Knife surgery as the historic gold standard in the treatment of trigeminal neuralgia (TN). TomoTherapy, a relative newcomer, has been approved by the U.S. FDA for various intracranial pathologies but is currently off label for the treatment of TN. A 73-year-old female presented with gait instability, intermittent headaches, and confusion. She was treated with TomoTherapy for refractory TN at an outside facility, which failed to reduce her symptoms. Magnetic resonance imaging demonstrated a lesion in the right mesial temporal lobe. A standard right anterior temporal lobectomy was performed and the final pathological report was notable for necrosis, gliosis, and edema consistent with a remote radiation injury. The patient improved postoperatively, but at her two-year follow up, she continued to have persistent bilateral TN and new onset seizures. Imaging revealed no new mass in the resection field. Stereotactic radiosurgery (SRS) is an evolving field with broadening indications, which makes it ever more important for physicians to be aware of differences between various SRS modalities. This case report highlights a cautionary example, and emphasizes the need for a more systematic evaluation of novel SRS methods before clinical application.

838Patient Outcomes and Surgical Complications in Coccidioidal Meningitis: An Institutional Review

Meningitis: An Institutional Review Ana Moran, MD; Wyatt Ramey; Brian Beck MD; Yashar Kalani, MD, PhD; Andrew Montoure; Kris Smith; Nicholas Theodore, MD; Peter Nakaji, MD; Omar Gonzalez, MD; Infectious Diseases, Barrow Neurological Institute, Phoenix, AZ; Barrow Neurological Institute, Phoneix, AZ; Neurology, Barrow Neurological Institute, Phoenix, AZ; Neurosurgery, Barrow Neurological Institute, St. Joseph Hospital, Phoenix, AZ; Neurosurgery, Barrow Neurological Institute, Phoenix, AZ; Arizona Pulmonary Specialists, Phoenix, AZ