Andrew N. Tyler

Fast atom bombardment: A new mass spectrometric method for peptide sequence analysis

Abstract We have studied a selection of peptides using a new mass spectrometric ionisation technique - fast atom bombardment (FAB). We define the fragmentation pathways observed and comment on the utility in sequence analysis. A simple acetylation experiment is shown to aid rapid sequence assignment.

Fast atom bombardment of solids (F.A.B.): a new ion source for mass spectrometry

A new method for obtaining high-quality mass spectra of molecules which previously were difficult or impossible to study by ionisation methods is described

Fast atom bombardment mass spectrometry of bleomycin A2 and B2 and their metal complexes.

Abstract The new mass spectrometric technique of fast atom bombardment is applied to the analysis of bleomycins either separately or in mixtures. The spectra are reproducible and afford valuable analytical data and structurally significant fragmentation patterns on these important antibiotics. The procedures outlined have also enabled the characterisation of various metal complexes.

Fast Atom Bombardment mass spectra of involatile sulphonated and phosphonated azo dyestuffs

Abstract Positive and negative ion Fast Atom Bombardment mass spectra have been obtained for involatile mono- and disazo dyestuffs, containing up to five sulphonate and phosphonate groups. The spectra are discussed with special reference to the ions formed by cleavage of the azo linkages in both the mono- and disazo compounds. Characteristic fragment ions are also found for a compound containing a pyrazolone ring.