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Andrew Richard Whittington

GlaxoSmithKline

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Publication

Featured researches published by Andrew Richard Whittington.

Bioorganic & Medicinal Chemistry Letters | 2009

Pyridine-3-carboxamides as novel CB 2 agonists for analgesia

William Leonard Mitchell; Gerard Martin Paul Giblin; Alan Naylor; Andrew John Eatherton; Brian P. Slingsby; Anthony D. Rawlings; Karamjit S. Jandu; Carl Haslam; Andrew J. Brown; Paul Goldsmith; Nick M. Clayton; Alex W. Wilson; Iain P. Chessell; Richard Howard Green; Andrew Richard Whittington; Ian D. Wall

We describe herein the medicinal chemistry approach which led to the discovery of a novel pyridine-3-carboxamide series of CB(2) receptor agonists. The SAR of this new template was evaluated and culminated in the identification of analogue 14a which demonstrated efficacy in an in vivo model of inflammatory pain.

Archive | 2003

Pyridine derivatives as cb2 receptor modulators

Andrew John Eatherton; Gerard Martin Paul Giblin; Richard Howard Green; Jennifer Margaret Doughty; Karamjit Singh Jandu; William Leonard Mitchell; Alan Naylor; Giovanni Palombi; Derek Anthony Rawlings; Brian Peter Slingsby; Andrew Richard Whittington

Archive | 2005

Combination Of Cb2 Modulators And Pde4 Inhibitors For Use In Medicine

Andrew J. Brown; Helen Elizabeht Connor; Andrew John Eatherton; Gerard Martin Paul Giblin; Richard Howard Green; Jennifer Margaret Doughty; Karamjit Singh Jandu; Richard G. Knowles; William Leonard Mitchell; Alan Naylor; Celestine T. O'Shaughnessy; Giovanni Palombi; Derek Anthony Rawlings; Brian Peter Slingsby; Catherine Jane Tralau-Stewart; Andrew Richard Whittington; Richard A. Williamson

Archive | 2005

DERIVES DE PYRIDINE MODULATEURS DU RECEPTEUR CB2

Andrew John Eatherton; Gerard Martin Paul Giblin; Richard Howard Green; Karamjit Singh Jandu; William Leonard Mitchell; Alan Naylor; Giovanni Palombi; Derek Anthony Rawlings; Brian Peter Slingsby; Andrew Richard Whittington

Archive | 2005

DERIVES DE PYRIMIDINE ET LEUR UTILISATION EN TANT QUE MODULATEURS CB2

Gerard Martin Paul Giblin; Andrew John Eatherton; Richard Howard Green; William Leonard Mitchell; Alan Naylor; Derek Anthony Rawlings; Brian Peter Slingsby; Andrew Richard Whittington

Archive | 2005

Combinaison de modulateurs du cb2 et d'inhibiteurs de la pde4 utilisee en medecine

Andrew J. Brown; Helen E. Connor; Andrew John Eatherton; Gerard Martin Paul Giblin; Karamjit Singh Jandu; Richard G. Knowles; William Leonard Mitchell; Alan Naylor; Celestine T. O'Shaughnessy; Giovanni Palombi; Derek Anthony Rawlings; Brian Peter Slingsby; Catherine Jane Tralau-Stewart; Andrew Richard Whittington; Richard A. Williamson; Richard Howard Green

Archive | 2003

Pyrimidinderivate und deren Verwendung als CB2-Modulatoren

Andrew John Eatherton; Gerard Martin Paul Giblin; William Leonard Mitchell; Alan Naylor; Brian Peter Slingsby; Andrew Richard Whittington; Richard Howard Green; Derek Anthony Rawlings

Archive | 2003

Pyrimidinderivate und deren Verwendung als CB2-Modulatoren Pyrimidine derivatives and their use as CB2 modulators

Andrew John Eatherton; Gerard Martin Paul Giblin; William Leonard Mitchell; Alan Naylor; Brian Peter Slingsby; Andrew Richard Whittington; Richard Howard Green; Derek Anthony Rawlings

Archive | 2003

Pyridine derivatives as modulators of the CB2 receptor

Andrew John Eatherton; Gerard Martin Paul Giblin; Richard Howard Green; Karamjit Singh Jandu; William Leonard Mitchell; Alan Naylor; Giovanni C; Derek Anthony Rawlings; Brian Peter Slingsby; Andrew Richard Whittington

Archive | 2003

Dérivés de la pyrimidine et leur utilisation comme modulateurs de CB2

Andrew John Eatherton; Gerard Martin Paul Giblin; William Leonard Mitchell; Alan Naylor; Brian Peter Slingsby; Andrew Richard Whittington; Richard Howard Green; Derek Anthony Rawlings

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Collaboration

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Andrew John Eatherton

GlaxoSmithKline

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Gerard Martin Paul Giblin

GlaxoSmithKline

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Richard Howard Green

GlaxoSmithKline

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William Leonard Mitchell

GlaxoSmithKline

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Derek Anthony Rawlings

University of California

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Brian Peter Slingsby

University of Hertfordshire

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Alan Naylor

GlaxoSmithKline

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Keith Thomas Bunce

University of California

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R.M. Hagan

University of Hertfordshire

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Andrew B. McElroy

Research Triangle Park

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