Aneela Karim

Enantioselective reduction of aromatic ketones catalysed by chiral ruthenium(II) complexes

Abstract The catalytic enantioselective reduction of aromatic ketones in 2-propanol is carried out by using ruthenium(II) complexes prepared from [Ru( p -cymene)Cl 2 ] 2 and a variety of chiral diamines and β-aminoalcohols derived from α-amino acids. Good conversions (>99%) and enantioselectivities (=96%) are observed under mild reaction conditions.

Evaluation of the thiazole Schiff bases as \(\upbeta \)-glucuronidase inhibitors and their in silico studies

Twenty eight (28) derivatives 2–29 were synthesized and four analogs were found to exhibit single-digit

A new glycotoxins inhibitor attenuates insulin resistance in liver and fat cells.

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Synthesis of V2O5 nanoparticles in reverse micelles

IC50 values as

New isatin derivative inhibits neurodegeneration by restoring insulin signaling in brain

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The conversion of biomass into liquid hydrocarbon fuel by two step pyrolysis using cement as catalyst.

β-glucuronidase inhibitors. Molecular modeling indicates that three factors: substituent R, lone pair on the nitrogen of azomethine part, and the interactions made by the main skeleton of the molecule, determined the enzyme inhibitory potential of these compounds. The planar conformation of the molecules allows them to fit deep inside the pocket while blocking the entry of other physiological substrates seems to play an important role in their activity.