Angel Golimstok

Enfermedad de Alzheimer. Guía de práctica clínica

Resumen El Grupo de Trabajo de Neurologia de la Conducta y Neurociencias Cognitivas de la Sociedad Neurologica Argentina publico en 2006 la primera Guia de practica clinica sobre la enfermedad de Alzheimer para su aplicacion en nuestro medio y, eventualmente, en el resto de los paises hispanoparlantes del Cono Sur. La Guia que hoy publicamos, mediante la revision y actualizacion del estado actual del conocimiento sobre la enfermedad de Alzheimer y su manejo clinico y neurologico, provee a los profesionales los estandares surgidos de la medicina basada en la evidencia para una adecuada implementacion de las conductas diagnosticas y terapeuticas a su alcance en nuestro medio.

Risk factors for dementia with Lewy bodies: A case-control study

Boot et al.1 studied several risk factors for dementia with Lewy bodies (DLB). We reported that the history of attention-deficit/hyperactivity disorder (ADHD) symptoms in adults is a risk …

Thalamus volume change and cognitive impairment in early relapsing–remitting multiple sclerosis patients

Aims The objective of the study was to assess whether changes in the volume of the thalamus during the onset of multiple sclerosis predict cognitive impairment after accounting for the effects of brain volume loss. Methods A prospective study included patients with relapsing–remitting multiple sclerosis less than 3 years after disease onset (defined as the first demyelinating symptom), Expanded Disability Status Scale of 3 or less, no history of cognitive impairment and at least 2 years of follow-up. Patients were clinically followed up with annual brain magnetic resonance imaging and neuropsychological evaluations for 2 years. Measures of memory, information processing speed and executive function were evaluated at baseline and follow-up with a comprehensive neuropsychological test battery. After 2 years, the patients were classified into two groups, one with and the other without cognitive impairment. Brain dual-echo, high-resolution three-dimensional T1-weighted magnetic resonance imaging scans were acquired at baseline and every 12 months for 2 years. Between-group differences in thalamus volume, total and neocortical grey matter and white matter volumes were assessed using FIRST, SIENA, SIENAXr, FIRST software (logistic regression analysis P < 0.05 significant). Results Sixty-one patients, mean age 38.4 years, 35 (57%) women were included. At 2 years of follow-up, 17 (28%) had cognitive impairment. Cognitive impairment patients exhibited significantly slower information processing speed and attentional deficits compared with patients without cognitive impairment (P < 0.001 and P = 0.02, respectively). In the cognitive impairment group a significant reduction in the percentage of thalamus volume (P < 0.001) was observed compared with the group without cognitive impairment. Conclusion We observed a significant decrease in thalamus volume in multiple sclerosis-related cognitive impairment.

Impact of disinhibition and apathy on progression from mild cognitive impairment to dementia

P4-180 IMPACT OF DISINHIBITION AND APATHY ON PROGRESSION FROM MILD COGNITIVE IMPAIRMENT TO DEMENTIA AngelGolimstok, Cecilia Fernandez, Nuria C ampora, Maria Jose Garcia Basalo, Erica Bogliotti, Marcela Fernandez, Lorena Zaifrani, Juan Rojas, Edgardo Cristiano, Italian Hospital, Buenos Aires, Argentina; Italian Hospital of Buenos Aires, Italian Hospital, Argentina; Italian Hospital, Buenoa Aires, Argentina. Contact e-mail: agolimstok@ gmail.com