Angela Cuenca

MICELLAR EFFECTS UPON THE ALKALINE HYDROLYSIS OF 2-(3-NITROPHENOXY)QUINOXALINE. EFFECTS OF CATIONIC HEAD GROUPS

Abstract The rate of alkaline hydrolysis of the novel compound 2-(3-nitrophenoxy)quinoxaline 1 increases with increasing head group size in a series of cationic micellized surfactants (C 16 H 33 NR 3 Cl and C 16 H 33 NR 3 OH: R = Me, Et, n -Pr and n -Bu). The reactivity increase with increasing head group size is related to the disruption of the hydration of hydroxide ion.

ALKALINE HYDROLYSIS OF 2-PHENOXYQUINOXALINE IN REACTIVE COUNTER-ION MICELLES : EFFECTS OF HEAD GROUP SIZE

The reaction of 2-phenoxyquinoxaline (1) with hydroxide ion is accelerated by reactive counter-ion micelles of cetyltrialkylammonium hydroxides (alkyl=Me, Et, n-Pr, and n-Bu), cetylmethylpiperidinium hydroxide, and cetylquinuclidinium hydroxide containing bulky head groups. First-order rate constants for reaction of (1) with OH− increase with increasing bulk of the head group and are associated with an increase in nucleophile reactivity as water is squeezed away from the micelle surface. Micellar effects upon the alkaline hydrolysis of compound (1) were analyzed by using a model that describes micelle-ion interactions in terms of Langmuir isotherms.

SILVER(I)-CATALYZED SYNTHESIS OF NOVEL QUINOXALINE DERIVATIVES

ABSTRACT The one-pot reaction of 2-chloroquinoxaline with phenoxide ion derivatives utilizing Ag+ as catalyst provided an efficient method for the preparation of five novel quinoxaline derivatives.

Synthesis of 2-(2-nitrophenoxy)quinoxaline and its basic hydrolysis in aqueous solutions of non-reactive counter-ion surfactants with bulky head groups

Abstract The synthesis of the novel compound 2-(2-nitrophenoxy)quinoxaline (2) is described and its basic hydrolysis was studied in the presence of non-reactive counter-ion surfactants with different head group size. Micellar effects upon the reaction of OH− with (2) were analyzed by using a massaction-like equation.

A Convenient and Rapid Preparation of Novel Quinoxaline Derivatives

Abstract A simple and rapid method for the preparation of a series of novel quinoxaline derivatives in the presence of Ag+ is reported.

Synthesis of 2-(4-nitrophenoxy)quinoxaline and its reactions with hydroxide ion in micellar systems

Abstract The synthesis of 2-(4-nitrophenoxy)quinoxaline (3) is described. The reaction of (3) with hydroxide ion was studied in the presence and absence of micellar systems. Cationic micelles of cetyltrimethylammonium chloride and bromide (CTACl and CTABr) and tetradecyltrimethylammonium chloride and bromide (MTACl and MTABr) speed the reaction of (3) with hydroxide ion. The second-order rate constants at the micellar pseudophase are smaller than the second-order rate constant in water.