Angela K. Hammond
ZymoGenetics
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Publication
Featured researches published by Angela K. Hammond.
Nature Immunology | 2004
Stacey R. Dillon; Cindy A. Sprecher; Angela K. Hammond; Janine Bilsborough; Maryland Rosenfeld-Franklin; Scott R. Presnell; Harald S. Haugen; Mark Maurer; Brandon Harder; Janet V. Johnston; Susan Bort; Sherri Mudri; Joseph L. Kuijper; Tom Bukowski; Pamela Shea; Dennis L. Dong; Maria M. Dasovich; Francis J. Grant; Luann Lockwood; Steven D. Levin; Cosette LeCiel; Kim Waggie; Heather Day; Stavros Topouzis; Janet M. Kramer; Rolf E. Kuestner; Zhi Chen; Don Foster; Julia Parrish-Novak; Jane A. Gross
T cell–derived cytokines are important in the development of an effective immune response, but when dysregulated they can promote disease. Here we identify a four-helix bundle cytokine we have called interleukin 31 (IL-31), which is preferentially produced by T helper type 2 cells. IL-31 signals through a receptor composed of IL-31 receptor A and oncostatin M receptor. Expression of IL-31 receptor A and oncostatin M receptor mRNA was induced in activated monocytes, whereas epithelial cells expressed both mRNAs constitutively. Transgenic mice overexpressing IL-31 developed severe pruritis, alopecia and skin lesions. Furthermore, IL-31 receptor expression was increased in diseased tissues derived from an animal model of airway hypersensitivity. These data indicate that IL-31 may be involved in promoting the dermatitis and epithelial responses that characterize allergic and non-allergic diseases.
European Journal of Immunology | 2011
Steven D. Levin; David W. Taft; Cameron S. Brandt; Christoph Bucher; Edward D. Howard; Eric M. Chadwick; Janet V. Johnston; Angela K. Hammond; Kristen Bontadelli; Daniel Ardourel; LuAnn Hebb; Anitra Wolf; Thomas R. Bukowski; Mark W. Rixon; Joseph L. Kuijper; Craig D. Ostrander; James W. West; Janine Bilsborough; Brian A. Fox; Zeren Gao; Wenfeng Xu; Fred Ramsdell; Bruce R. Blazar; Katherine E. Lewis
Members of the CD28 family play important roles in regulating T‐cell functions and share a common gene structure profile. We have identified VSTM3 as a protein whose gene structure matches that of the other CD28 family members. This protein (also known as TIGIT and WUCAM) has been previously shown to affect immune responses and is expressed on NK cells, activated and memory T cells, and Tregs. The nectin‐family proteins CD155 and CD112 serve as counter‐structures for VSTM3, and CD155 and CD112 also bind to the activating receptor CD226 on T cells and NK cells. Hence, this group of interacting proteins forms a network of molecules similar to the well‐characterized CD28–CTLA‐4–CD80–CD86 network. In the same way that soluble CTLA‐4 can be used to block T‐cell responses, we show that soluble Vstm3 attenuates T‐cell responses in vitro and in vivo. Moreover, animals deficient in Vstm3 are more sensitive to autoimmune challenges indicating that this new member of the CD28 family is an important regulator of T‐cell responses.
Archive | 2006
Julia E. Novak; Scott R. Presnell; Cindy A. Sprecher; Donald C. Foster; Richard D. Holly; Jane A. Gross; Janet V. Johnston; Andrew J. Nelson; Stacey R. Dillon; Angela K. Hammond
Archive | 2003
Cindy A. Sprecher; Zeren Gao; Joseph L. Kuijper; Maria M. Dasovich; Francis J. Grant; Scott R. Presnell; Theodore E. Whitmore; Angela K. Hammond; Julia E. Novak; Jane A. Gross; Stacey R. Dillon
Archive | 2003
Cindy A. Sprecher; Joseph L. Kuijper; Maria M. Dasovich; Francis J. Grant; Angela K. Hammond; Julia E. Novak; Jane A. Gross; Stacey R. Dillon
Archive | 2003
Cindy A. Sprecher; Joseph L. Kuijper; Maria M. Dasovich; Francis J. Grant; Angela K. Hammond; Julia E. Novak; Jane A. Gross; Stacey R. Dillon
Archive | 2005
Cindy A. Sprecher; Joseph L. Kuijper; Maria M. Dasovich; Francis J. Grant; Angela K. Hammond; Jane A. Gross
Archive | 2006
Cindy A. Sprecher; Joseph L. Kuijper; Maria M. Dasovich; Francis J. Grant; Angela K. Hammond; Jane A. Gross
Archive | 2001
Julia E. Novak; Scott R. Presnell; Cindy A. Sprecher; Donald C. Foster; Richard D. Holly; Jane A. Gross; Janet V. Johnston; Andrew J. Nelson; Stacey R. Dillon; Angela K. Hammond
Archive | 1999
Scott R. Presnell; Darrell Conklin; Julia E. Novak; Angela K. Hammond