Angela L. Neville
University of Southern California
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Journal of Trauma-injury Infection and Critical Care | 2012
David Plurad; Scott Bricker; Ann Falor; Angela L. Neville; Frederic S. Bongard; Brant Putnam
BACKGROUND Hormone replacement therapy (HRT) use for donors with hemodynamic instability is common. The purpose of this study was to determine the effect of HRT in donors without significant cardiovascular dysfunction and examine outcomes according to vasopressor exposure. METHODS All successfully procured donors admitted between January 1, 2006, and March 31, 2011, were included. HRT group I were donors without significant hemodynamic instability at the initiation of HRT. Comparison was made to all other donors receiving HRT (HRT group II). Vasopressor use was also examined and compared. High-yield procurement was the successful recovery of ≥4 organs. RESULTS Forty-seven donors were studied. Most were male (36 [76.6%]) and trauma (41% [87.2%]) predominated. Twenty-two (46.8%) patients were in HRT group I. There were no differences in gender, admission diagnosis, or complications; however, HRT group I had a significantly greater number of organs recovered (4.73 ± 1.42 vs. 3.08 ± 1.19, p < 0.001). Differences in rates for the heart (68.2% vs. 24%, p = 0.002) and lung (40.9% vs. 8.0%, p = 0.008) were marked. HRT group I was more likely managed on a single agent (45.5% vs. 8.0%, p = 0.003). Norepinephrine was associated with a decreased rate of high-yield procurement (48.0% vs. 77.3%, p = 0.039), while vasopressin exposure was associated with an absolute increase (72.0% vs. 59.1%, p = 0.351). After adjusting for differences between groups (particularly age), HRT group I status was independently associated with high-yield procurement. CONCLUSION A more liberal strategy of HRT seems to significantly increase procurement rates. Vasopressor selection favoring vasopressin as opposed to norepinephrine may also play a role. LEVEL OF EVIDENCE Therapeutic study, level III.
Archives of Surgery | 2004
Angela L. Neville; Carlos Brown; Janie Weng; Demetrios Demetriades; George C. Velmahos
Journal of Trauma-injury Infection and Critical Care | 2005
Carlos Brown; Angela L. Neville; Peter Rhee; Ali Salim; George C. Velmahos; Demetrios Demetriades
Journal of Pediatric Surgery | 2006
Carlos Brown; Angela L. Neville; Ali Salim; Peter Rhee; Kyle G. Cologne; Demetrios Demetriades
Journal of Trauma-injury Infection and Critical Care | 2006
Carlos Brown; Peter Rhee; Angela L. Neville; Burapat Sangthong; Ali Salim; Demetrios Demetriades
Archives of Surgery | 2005
Carlos Brown; George C. Velmahos; Angela L. Neville; Peter Rhee; Ali Salim; Burapat Sangthong; Demetrios Demetriades
American Surgeon | 2014
Brian M. Nguyen; Dennis Kim; Scott Bricker; Fred Bongard; Angela L. Neville; Brant Putnam; Jennifer Smith; David Plurad
Journal of Trauma-injury Infection and Critical Care | 2005
Angela L. Neville; Peter F. Crookes; George C. Velmahos; Aggeliki Vlahos; Dimitrios Theodorou; Charles E. Lucas
American Surgeon | 2013
Eric B. McClellan; Scott Bricker; Angela L. Neville; Frederic S. Bongard; Brant Putnam; David Plurad
Journal of Trauma-injury Infection and Critical Care | 2005
Chelsea Brown; Angela L. Neville; Peter Rhee; Ali Salim; George C. Velmahos; Demetrios Demetriades