Angela Pecoraro
Vita-Salute San Raffaele University
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Angela Pecoraro.
Scientific Reports | 2016
Massimo Alfano; Manuela Nebuloni; Raffaele Allevi; Pietro Zerbi; Erika Longhi; Roberta Lucianò; Irene Locatelli; Angela Pecoraro; Marco Indrieri; Chantal Speziali; Claudio Doglioni; Paolo Milani; Francesco Montorsi; Andrea Salonia
In the fields of biomaterials and tissue engineering simulating the native microenvironment is of utmost importance. As a major component of the microenvironment, the extracellular matrix (ECM) contributes to tissue homeostasis, whereas modifications of native features are associated with pathological conditions. Furthermore, three-dimensional (3D) geometry is an important feature of synthetic scaffolds favoring cell stemness, maintenance and differentiation. We analyzed the 3D structure, geometrical measurements and anisotropy of the ECM isolated from (i) human bladder mucosa (basal lamina and lamina propria) and muscularis propria; and, (ii) bladder carcinoma (BC). Next, binding and invasion of bladder metastatic cell line was observed on synthetic scaffold recapitulating anisotropy of tumoral ECM, but not on scaffold with disorganized texture typical of non-neoplastic lamina propria. This study provided information regarding the ultrastructure and geometry of healthy human bladder and BC ECMs. Likewise, using synthetic scaffolds we identified linearization of the texture as a mandatory feature for BC cell invasion. Integrating microstructure and geometry with biochemical and mechanical factors could support the development of an innovative synthetic bladder substitute or a tumoral scaffold predictive of chemotherapy outcomes.
PLOS ONE | 2016
Luca Boeri; Eugenio Ventimiglia; Paolo Capogrosso; Silvia Ippolito; Angela Pecoraro; Marco Paciotti; Roberta Scano; Alessandro Galdini; Luca Valsecchi; Enrico Papaleo; Francesco Montorsi; Andrea Salonia
Individuals born with low birth weight (LBW) risk cardiometabolic complications later in life. However the impact of LBW on general health status and male reproductive function has been scantly analysed. We investigated the clinical and seminal impact of different birth weights (BW) in white-European men presenting for primary couple’s infertility. Demographic, clinical, and laboratory data from 827 primary infertile men were compared with those of 373 consecutive fertile men. Patients with BW ≤2500, 2500–4200, and ≥4200gr were classified as having LBW, normal (NBW), and high BW (HBW), respectively. Health-significant comorbidities were scored with the Charlson Comorbidity Index (CCI). Testicular volume was assessed with a Prader orchidometer. Semen analysis values were assessed based on 2010 WHO reference criteria. Descriptive statistics and regression models tested associations between semen parameters, clinical characteristics and BW categories. LBW, NBW and HBW were found in 71 (8.6%), 651 (78.7%) and 105 (12.7%) infertile men, respectively. LBW was more frequent in infertile patients than fertile men (p = 0.002). Infertile patients with LBW had a higher rate of comorbidities (p = 0.003), lower mean testicular volume (p = 0.007), higher FSH (p = 0.02) and lower tT levels (p = 0.04) compared to other BW groups. Higher rates of asthenozoospermia (p = 0.02) and teratozoospermia (p = 0.03) were also found in LBW men. At logistic regression models, LBW was univariably associated with pathologic progressive motility (p≤0.02) and pathologic sperm morphology (p<0.005). At multivariable logistic regression analysis, LBW achieved independent predictor status for both lower sperm motility and pathologic sperm morphology (all p≤0.04). Only LBW independently predicted higher CCI values (p<0.001). In conclusion, we found that LBW was more frequent in infertile than in fertile men. Infertile individuals with LBW showed a higher rate of comorbidities and significantly worse clinical, endocrine and semen parameters compared to other BW groups.
European Urology Supplements | 2015
Luca Boeri; Paolo Capogrosso; Eugenio Ventimiglia; G. La Croce; Alessandro Serino; Angela Pecoraro; Marco Paciotti; Silvia Ippolito; Giulia Castagna; Roberta Scano; Rocco Damiano; F. Montorsi; Andrea Salonia
INTRODUCTION AND OBJECTIVES: The raise of the developmental origins of adult disease has positioned low birth weight (LBW) as a significant health issue. We assessed prevalence of, and clinical and seminal impact of different categories of weight at birth in a cohort of white-European men presenting for primary couple’s infertility. METHODS: Complete data from 757 consecutive infertile men were analyzed. Patient with birth weight 2500, 2500 e 4200, and 4200 gr were considered as having LBW, normal birth weight (NBW) and high birth weight (HBW), respectively. Comorbidities were scored with the Charlson Comorbidity Index (CCI; categorized 0 vs 1 vs 2). Body mass index (BMI) was considered for each patient using NIH cut offs [normal weight (18.5e24.9), overweight (25.0e29.9), and class 1 obesity ( 30.0)]. Testicular volume (TV) was assessed with a Prader orchidometer. Semen analysis values were assessed based on 2010 WHO reference criteria. Descriptive statistics detailed the association between semen parameters and clinical characteristics and the defined birth weight categories. RESULTS: Of all, LBW, NBW and HBW were found in 52 (6.9%), 605 (79.9%) and 100 (13.2%) men, respectively. Normal BMI value and BMI suggestive for NIH class 1 obesity was more frequently reported in LBW and HBW (p<0.001), respectively. Of all, LBW reported a higher prevalence of comorbidities (p<0.001). Likewise, hypercholesterolemia (p1⁄40.04) and hypertriglyceridemia (p1⁄40.01) were more frequently reported in both LBW and HBW. LBW had a lower mean TV (p1⁄40.02). At semen analysis, LBW men showed a higher rate of both asthenozoospermia (p1⁄40.02) and teratozoospermia (p1⁄40.02). Overall, ejaculated volume (p1⁄40.006), sperm motility (p1⁄40.02) and normal morphology (p1⁄40.04) were significantly reduced in the LBW group. Likewise, LBW patients presented higher FSH levels (p1⁄40.04) but lower circulating testosterone levels (p1⁄40.03) as compared with the other groups. At MVA, LBW achieved independent predictor status for a higher CCI value (OR 3.7; p<0.001), lower sperm motility (OR 2.7; p<0.04), and lower normal sperm morphology (OR 2.3; p<0.04). CONCLUSIONS: Current findings in infertile patients showed that LBW was associated with a significant higher rate of adult diseases. Clinical, endocrine and semen parameters were significantly worse in the LBW group. These data confirmed the importance of the theory of LBW as a significant predictor of impaired health issue.
World Journal of Urology | 2018
Fabio Muttin; Angela Pecoraro; Alessandro Larcher; Paolo Dell’Oglio; Alessandro Nini; Francesco Cianflone; Francesco Trevisani; Federico Dehò; Alberto Briganti; Andrea Salonia; Francesco Montorsi; Roberto Bertini; Umberto Capitanio
The Journal of Urology | 2015
Paolo Capogrosso; Alessandro Serino; Luca Boeri; Giovanni La Croce; Eugenio Ventimiglia; Angela Pecoraro; Marco Paciotti; Giulia Castagna; E. Farina; Giorgio Gandaglia; Alberto Briganti; Rocco Damiano; Francesco Montorsi; Andrea Salonia
The Journal of Urology | 2015
Eugenio Ventimiglia; Paolo Capogrosso; Luca Boeri; Alessandro Serino; Giovanni La Croce; Giulia Castagna; Angela Pecoraro; Marco Paciotti; Roberta Scano; Dana Kuefner; Rocco Damiano; Francesco Montorsi; Andrea Salonia
The Journal of Urology | 2015
Luca Boeri; Alessandro Serino; Eugenio Ventimiglia; Giovanni La Croce; Paolo Capogrosso; Marco Paciotti; Angela Pecoraro; Silvia Ippolito; Giulia Castagna; Roberta Scano; Dana Kuefner; Rocco Damiano; Francesco Montorsi; Andrea Salonia
The Journal of Urology | 2015
Alessandro Serino; Paolo Capogrosso; Luca Boeri; Eugenio Ventimiglia; Giovanni La Croce; Giulia Castagna; Angela Pecoraro; Marco Paciotti; Silvia Ippolito; Roberta Scano; Rocco Damiano; Francesco Montorsi; Andrea Salonia
The Journal of Urology | 2015
Luca Boeri; Paolo Capogrosso; Eugenio Ventimiglia; Alessandro Serino; Giovanni La Croce; Angela Pecoraro; Marco Paciotti; Silvia Ippolito; Giulia Castagna; Roberta Scano; Rocco Damiano; Francesco Montorsi; Andrea Salonia
The Journal of Urology | 2015
Eugenio Ventimiglia; Luca Boeri; Paolo Capogrosso; Giovanni La Croce; Alessandro Serino; Giulia Castagna; Angela Pecoraro; Marco Paciotti; Roberta Scano; Alberto Briganti; Francesco Cantiello; Rocco Damiano; Francesco Montorsi; Andrea Salonia