Angela Wei Hong Yang

Efficacy and Safety of a Chinese Herbal Medicine Formula (RCM-104) in the Management of Simple Obesity: A Randomized, Placebo-Controlled Clinical Trial

Objective. This study was to evaluate the efficacy and safety of a Chinese herbal medicine formula (RCM-104) for the management of simple obesity. Method. Obese subjects aged between 18 and 60 years were selected for 12-week, double-blind, randomized, placebo-controlled trial. Subjects were randomly assigned to take 4 capsules of either the RCM-104 formula (n = 59) or placebo (n = 58), 3 times daily for 12 weeks. Measures of BW, BMI and WC, HC, WHR and BF composition were assessed at baseline and once every four weeks during the 12 week treatment period. Results. Of the 117 subjects randomised, 92 were included in the ITT analysis. The weight, BMI and BF in RCM-104 group were reduced by 1.5 kg, 0.6 kg/m2 and 0.9% and those in the placebo group were increased by 0.5 kg, 0.2 kg/m2 and 0.1% respectively. There were significant differences in BW and BMI (P < 0.05) between the two groups. Eleven items of the WLQOQ were significantly improved in the RCM-104 group while only 2 items were significantly improved in the placebo group. Adverse events were minor in both groups. Conclusion. RCM-104 treatment appears to be well tolerated and beneficial in reducing BW and BMI in obese subjects.

Topical Application of Chinese Herbal Medicine for Atopic Eczema: A Systematic Review with a Meta-Analysis

Background: Atopic eczema (AE) affects 10-20% of children in industrialised countries. Objective: This review systematically evaluated the effects and safety of topical use of Chinese herbal medicine (CHM) for AE. Methods: Randomised controlled trials on topical use of CHM were identified through searching electronic databases. Their risk of bias was assessed. Meta-analysis was conducted by employing the RevMan 5.2 software. Results: Ten studies involving 1,058 participants were included. These studies had high risk of bias in randomisation, blinding and outcome data. Meta-analysis showed that topical applications of CHM were superior to conventional medications in total effectiveness rate (risk ratio 1.19; 95% confidence interval 1.04 to 1.36). No significant difference was observed in overall skin lesion score (standardised mean difference -0.05; 95% confidence interval -0.88 to 0.78) compared to corticosteroid creams. Conclusions: There was no conclusive evidence to demonstrate that topical application of CHM for AE was superior to other control interventions due to methodological weaknesses of the included randomised controlled trials.

Using IS/IT to support the delivery of Chinese medicine: The design of a Chinese medicine clinic system

Using Information System/Information Technology (IS/IT) in Chinese Medicine (CM) has not been discussed much, if at all, in the literature. This is unlike the numerous references to the role for IS/IT to support various aspects of western medicine practice. Though the diagnosis and treatments between western medicine and CM are different, the clinical processes are similar. Thus, we contend that by implementing IS/IT system solutions, CM practice can also enjoy many benefits. CM practice relies on expert knowledge, hence applying knowledge management (KM) concepts to any proposed Chinese Medicine Clinic System (CMCS) is a necessary critical factor in the design of suitable IS/IT solutions in this context. This paper serves to identify a role for IS/IT in assisting CM clinic daily key processes as well as identify key system features and functions for a suitable CMCS.

INVESTIGATING THE POSSIBILITY FOR IS/IT TO SUPPORT THE DELIVERY OF CHINESE MEDICINE

As Chinese medicine (CM) has increased in popularity globally it now becomes imperative to investigate ways in which safe, efficient, effective and evidence-based approaches might be adopted into CM practice. In the case of western or more traditional healthcare delivery practice, IS/IT is often adopted and employed to assist in this regard and thus this paper examines how IS/IT might be used to support the delivery of CM. In particular, the paper investigates how IS/IT tools and techniques might be used in supporting CM clinics daily processes and thereby bring greater value to a countrys healthcare. In doing so, this paper studies the current global CM situation and provides a solid foundation for how to design and develop an enterprise wide CM clinical management system.

Saposhnikoviae divaricata: a phytochemical, pharmacological, and pharmacokinetic review

Abstract Saposhnikoviae divaricata (Turcz.) Schischk (SD) is a traditional Chinese herb commonly used to treat clinical conditions such as rheumatism and allergic rhinitis. This review article evaluates a collection of works on in vitro and biochemical studies of SD. The discourse on the diverse class of chromones and coumarins in SD offers an insight to the pharmacological effects of these bioactive constituents as anti-inflammatory, analgesic, immunoregulatory, antioxidative, and anti-proliferative agents. It is highlighted that there is a structural relationship between the constituents and bioactive activities, which in effect provides a valid reasoning and reaffirm the use of SD in the treatment of the pathologies in Chinese medicine.

Do the Natural Chemical Compounds Interact with the Same Targets of Current Pharmacotherapy for Weight Management?-A Review

BACKGROUND Obesity has become a worldwide health concern. Pharmacotherapies are now being introduced because lifestyle modifications alone are insufficient for weight management. The treatment outcomes of current approved anti-obesity agents are not satisfying due to drug-related intolerances. And so natural therapies including herbal medicines are popular alternatives for weight reduction; however, there are limited studies about their mechanism of actions. METHODS Five databases (PubMed, Scopus, Google Scholar, Science Direct, Proquest) were searched to investigate the targets and safety profiles of the current and past anti-obesity drugs that have been approved by the Food and Drug Administration (FDA) or the European Medicines Agency (EMA) as well as the commonly used off-label agents. The targets for weight-loss natural products and their principle bioactive components have also been searched. Only articles in English were included. RESULTS The targets for current anti-obesity single agents include pancreatic lipase, Glucagon Like Peptide-1(GLP-1) receptor, and serotonin 2C (5-HT2C) receptor. Potential targets such as amylin, pancreatic alpha amylase, leptin receptor, melanocortin receptor 4 receptor (MC4R), Peroxisome Proliferator- Activated Receptors gamma (PPAR γ), endocannabinoid 1 (CB1) receptor and Adenosine Monophosphate (AMP)-Activated Protein Kinase (AMPK) were discussed in various studies. Natural compounds have been found to interact with targets like pancreatic lipase, pancreatic alpha amylase, AMPK and PPAR γ to achieve weight reduction. CONCLUSION Current pharmacotherapies and natural chemical compounds do act on same targets. Further investigations on the interactions between herbal compounds and the above targets are essential for the development of novel weight-loss therapies.

Acupressure for respiratory allergic diseases: a systematic review of randomised controlled trials

Objective To evaluate the effects and safety of acupressure for the management of respiratory allergic diseases by systematically reviewing randomised controlled trials (RCTs). Methods A total of 13 electronic English and Chinese databases were searched until July 2017. Two authors extracted data and evaluated risk of bias independently. Review Manager V.5.3 was employed for data analysis. Results The literature search identified 186 papers, of which only four of met the inclusion criteria: two for allergic rhinitis (AR) and two for asthma. High and unclear risk of bias existed across all the included studies. The findings demonstrated that acupressure greater effects on the relief of nasal symptoms of AR compared with 1% ephedrine nasal drop plus thermal therapy. With either Western medicine or Chinese herbal medicine as a cointervention, one study indicated that acupressure plus salbutamol was led to a significantly greater improvement of pulmonary function for patients with asthma compared with salbutamol only. However, the remaining two studies indentified no significant differences in any outcome measures between the two groups. Conclusions No reliable conclusions regarding the effects of acupressure on AR and asthma could be drawn by this review due to the small number of available trials with significant heterogeneity of study design and high/unclear risk of bias. Further, more rigorously designed RCTs are needed. Acupressure seems safe for symptomatic relief of AR and asthma, although larger studies are required to be able to robustly confirm its safety. Trial registration number ACTRN12617001106325; Pre-results.

An Investigation on Integrating Eastern and Western Medicine with Informatics

Today, in many western countries, acceptance of alternate forms of healthcare such as Chinese medicine (CM) is increasing. In fact, countries such as Australia, Canada, and England are going so far as to set regulations, education, and standards regarding the practice of CM in these respective countries. Further, we can see the integration between western and Chinese medicine delivery of care and treatments in many instances. Information systems and information technology (IS/IT) can be a key enabler in assisting this integration. The following study examines aspects of such integrations using IS/IT and identifies that CM IS/IT is more likely to succeed when there is synthesis between key aspects of the unique environment and user requirements. This perspective is supported theoretically by adapting Churchman’s inquiring systems to frame CM as a combination of Hegelian and Kantian inquiring systems with the support of Singerian, Lockean, and Leibnizian inquiring systems and knowledge management features. Based on this, the study then proposes a new design for a patient management system in clinics and hospitals.

Health Information Technology to Support the Delivery of Chinese Medicine: The Design of a Chinese Medicine Clinic System

Often we assume consumer health informatics to be only focused on Western medicine; however, this is a limiting view. Consumer health informatics is also as relevant to other forms of healthcare such as Chinese medicine (CM). Key issues and considerations that should be considered when designing CM clinic system are presented in this chapter. These findings are particularly relevant to today’s healthcare challenges, as healthcare reform agendas consider options and decisions to ensure effective, efficient, and efficacious value-driven patient-centric healthcare solutions.

Using IS/IT to support the delivery of Chinese medicine: a Chinese medicine clinic management system

OECD countries today are focusing on ways to incorporate IS/IT to facilitate superior healthcare delivery. However, studies of IS/IT implementations for Chinese Medicine (CM) practice are very limited. We analyse western medicine (WM) and CM diagnosis and treatment processes and find that these clinical processes share some similarities. Hence, we contend that by implementing IS/IT system solutions, CM practice can also enjoy similar benefits from IS/IT as WM. This paper serves to identify a role for IS/IT in assisting CM clinic key processes as well as identify key IT investment portfolio components of such IS/IT solutions.