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Dive into the research topics where Angeles Panadero is active.

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Featured researches published by Angeles Panadero.


Nature Genetics | 2011

Mutations in BRIP1 confer high risk of ovarian cancer

Thorunn Rafnar; Daniel F. Gudbjartsson; Patrick Sulem; Aslaug Jonasdottir; Asgeir Sigurdsson; Adalbjorg Jonasdottir; Søren Besenbacher; Pär Lundin; Simon N. Stacey; Julius Gudmundsson; Olafur T. Magnusson; Louise le Roux; Gudbjorg Orlygsdottir; Hafdis T. Helgadottir; Hrefna Johannsdottir; Arnaldur Gylfason; Laufey Tryggvadottir; Jon G. Jonasson; Ana de Juan; Eugenia Ortega; José Manuel Ramón-Cajal; María Dolores García-Prats; Carlos Mayordomo; Angeles Panadero; Fernando Rivera; Katja K. Aben; Anne M. van Altena; Leon F.A.G. Massuger; Mervi Aavikko; Paula Kujala

Ovarian cancer causes more deaths than any other gynecologic malignancy in developed countries. Sixteen million sequence variants, identified through whole-genome sequencing of 457 Icelanders, were imputed to 41,675 Icelanders genotyped using SNP chips, as well as to their relatives. Sequence variants were tested for association with ovarian cancer (N of affected individuals = 656). We discovered a rare (0.41% allelic frequency) frameshift mutation, c.2040_2041insTT, in the BRIP1 (FANCJ) gene that confers an increase in ovarian cancer risk (odds ratio (OR) = 8.13, P = 2.8 × 10−14). The mutation was also associated with increased risk of cancer in general and reduced lifespan by 3.6 years. In a Spanish population, another frameshift mutation in BRIP1, c.1702_1703del, was seen in 2 out of 144 subjects with ovarian cancer and 1 out of 1,780 control subjects (P = 0.016). This allele was also associated with breast cancer (seen in 6/927 cases; P = 0.0079). Ovarian tumors from heterozygous carriers of the Icelandic mutation show loss of the wild-type allele, indicating that BRIP1 behaves like a classical tumor suppressor gene in ovarian cancer.


Nature Genetics | 2012

Discovery of common variants associated with low TSH levels and thyroid cancer risk

Julius Gudmundsson; Patrick Sulem; Daniel F. Gudbjartsson; Jon G. Jonasson; Gisli Masson; Huiling He; Aslaug Jonasdottir; Asgeir Sigurdsson; Simon N. Stacey; Hrefna Johannsdottir; Hafdis T. Helgadottir; Wei Li; Rebecca Nagy; Matthew D. Ringel; Richard T. Kloos; Marieke de Visser; Theo S. Plantinga; Martin den Heijer; Esperanza Aguillo; Angeles Panadero; Enrique Prats; Almudena Garcia-Castaño; Ana de Juan; Fernando Rivera; G. Bragi Walters; Hjordis Bjarnason; Laufey Tryggvadottir; Gudmundur I. Eyjolfsson; Unnur S. Bjornsdottir; Hilma Holm

To search for sequence variants conferring risk of nonmedullary thyroid cancer, we focused our analysis on 22 SNPs with a P < 5 × 10−8 in a genome-wide association study on levels of thyroid stimulating hormone (TSH) in 27,758 Icelanders. Of those, rs965513 has previously been shown to associate with thyroid cancer. The remaining 21 SNPs were genotyped in 561 Icelandic individuals with thyroid cancer (cases) and up to 40,013 controls. Variants suggestively associated with thyroid cancer (P < 0.05) were genotyped in an additional 595 non-Icelandic cases and 2,604 controls. After combining the results, three variants were shown to associate with thyroid cancer: rs966423 on 2q35 (OR = 1.34; Pcombined = 1.3 × 10−9), rs2439302 on 8p12 (OR = 1.36; Pcombined = 2.0 × 10−9) and rs116909374 on 14q13.3 (OR = 2.09; Pcombined = 4.6 × 10−11), a region previously reported to contain an uncorrelated variant conferring risk of thyroid cancer. A strong association (P = 9.1 × 10−91) was observed between rs2439302 on 8p12 and expression of NRG1, which encodes the signaling protein neuregulin 1, in blood.


PLOS Genetics | 2010

Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus.

Simon N. Stacey; Patrick Sulem; Carlo Zanon; Sigurjon A. Gudjonsson; Gudmar Thorleifsson; Agnar Helgason; Aslaug Jonasdottir; Søren Besenbacher; Jelena Kostic; James D. Fackenthal; Dezheng Huo; Clement Adebamowo; Temidayo O. Ogundiran; Janet E. Olson; Zachary S. Fredericksen; Xianshu Wang; Maxime P. Look; Anieta M. Sieuwerts; John W.M. Martens; Isabel Pajares; María Dolores García-Prats; José Manuel Ramón-Cajal; Ana de Juan; Angeles Panadero; Eugenia Ortega; Katja K. Aben; Sita H. Vermeulen; Fatemeh Asadzadeh; K. C.Anton van Engelenburg; Sara Margolin

We used an approach that we term ancestry-shift refinement mapping to investigate an association, originally discovered in a GWAS of a Chinese population, between rs2046210[T] and breast cancer susceptibility. The locus is on 6q25.1 in proximity to the C6orf97 and estrogen receptor α (ESR1) genes. We identified a panel of SNPs that are correlated with rs2046210 in Chinese, but not necessarily so in other ancestral populations, and genotyped them in breast cancer case∶control samples of Asian, European, and African origin, a total of 10,176 cases and 13,286 controls. We found that rs2046210[T] does not confer substantial risk of breast cancer in Europeans and Africans (OR = 1.04, P = 0.099, and OR = 0.98, P = 0.77, respectively). Rather, in those ancestries, an association signal arises from a group of less common SNPs typified by rs9397435. The rs9397435[G] allele was found to confer risk of breast cancer in European (OR = 1.15, P = 1.2×10−3), African (OR = 1.35, P = 0.014), and Asian (OR = 1.23, P = 2.9×10−4) population samples. Combined over all ancestries, the OR was 1.19 (P = 3.9×10−7), was without significant heterogeneity between ancestries (Phet = 0.36) and the SNP fully accounted for the association signal in each ancestry. Haplotypes bearing rs9397435[G] are well tagged by rs2046210[T] only in Asians. The rs9397435[G] allele showed associations with both estrogen receptor positive and estrogen receptor negative breast cancer. Using early-draft data from the 1,000 Genomes project, we found that the risk allele of a novel SNP (rs77275268), which is closely correlated with rs9397435, disrupts a partially methylated CpG sequence within a known CTCF binding site. These studies demonstrate that shifting the analysis among ancestral populations can provide valuable resolution in association mapping.


Nature Communications | 2013

A common variant at 8q24.21 is associated with renal cell cancer

Julius Gudmundsson; Patrick Sulem; Daniel F. Gudbjartsson; Gisli Masson; Vigdis Petursdottir; Sverrir Hardarson; Sigurjon A. Gudjonsson; Hrefna Johannsdottir; Hafdis T. Helgadottir; Simon N. Stacey; Olafur T. Magnusson; Hannes Helgason; Angeles Panadero; Loes F.M. van der Zanden; Katja K. Aben; Sita H. Vermeulen; Egbert Oosterwijk; Augustine Kong; Jose I. Mayordomo; Asgerdur Sverrisdottir; Eirikur Jonsson; Tomas Gudbjartsson; Gudmundur V. Einarsson; Lambertus A. Kiemeney; Unnur Thorsteinsdottir; Thorunn Rafnar; Kari Stefansson

Renal cell carcinoma (RCC) represents between 80 and 90% of kidney cancers. Previous genome-wide association studies of RCC have identified five variants conferring risk of the disease. Here we report the results from a discovery RCC genome-wide association study and replication analysis, including a total of 2,411 patients and 71,497 controls. One variant, rs35252396[CG] located at 8q24.21, is significantly associated with RCC after combining discovery and replication results (OR=1.27, P(combined)=5.4 × 10(-11)) and has an average risk allele frequency in controls of 46%. rs35252396[CG] does not have any strongly correlated variants in the genome and is located within a region predicted to have regulatory functions in several cell lines, including six originating from the kidney. This is the first RCC variant reported at 8q24.21 and it is largely independent (r(2)≤0.02) of the numerous previously reported cancer risk variants at this locus.


Human Molecular Genetics | 2014

Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer.

Thorunn Rafnar; Patrick Sulem; Gudmar Thorleifsson; Sita H. Vermeulen; Hannes Helgason; Jona Saemundsdottir; Sigurjon A. Gudjonsson; Asgeir Sigurdsson; Simon N. Stacey; Julius Gudmundsson; Hrefna Johannsdottir; Kristin Alexiusdottir; Vigdis Petursdottir; Sigfus Nikulasson; Gudmundur Geirsson; Thorvaldur Jonsson; Katja K. Aben; Anne J. Grotenhuis; Gerald W. Verhaegh; Aleksandra M. Dudek; J. Alfred Witjes; Antoine G. van der Heijden; Alina Vrieling; Tessel E. Galesloot; Ana de Juan; Angeles Panadero; Fernando Rivera; Carolyn D. Hurst; D. Timothy Bishop; Sei C. Sak

Genome-wide association studies (GWAS) of urinary bladder cancer (UBC) have yielded common variants at 12 loci that associate with risk of the disease. We report here the results of a GWAS of UBC including 1670 UBC cases and 90 180 controls, followed by replication analysis in additional 5266 UBC cases and 10 456 controls. We tested a dataset containing 34.2 million variants, generated by imputation based on whole-genome sequencing of 2230 Icelanders. Several correlated variants at 20p12, represented by rs62185668, show genome-wide significant association with UBC after combining discovery and replication results (OR = 1.19, P = 1.5 × 10(-11) for rs62185668-A, minor allele frequency = 23.6%). The variants are located in a non-coding region approximately 300 kb upstream from the JAG1 gene, an important component of the Notch signaling pathways that may be oncogenic or tumor suppressive in several forms of cancer. Our results add to the growing number of UBC risk variants discovered through GWAS.


Cancer Research | 2011

Genome-Wide Significant Association Between a Sequence Variant at 15q15.2 and Lung Cancer Risk

Thorunn Rafnar; Patrick Sulem; Søren Besenbacher; Daniel F. Gudbjartsson; Carlo Zanon; Julius Gudmundsson; Simon N. Stacey; Jelena Kostic; Thorgeir E. Thorgeirsson; Gudmar Thorleifsson; Hjordis Bjarnason; Halla Skuladottir; Tomas Gudbjartsson; Helgi J. Ísaksson; Dolores Isla; Laura Murillo; María Dolores García-Prats; Angeles Panadero; Katja K. Aben; Sita H. Vermeulen; Henricus F. M. van der Heijden; William J. Feser; York E. Miller; Paul A. Bunn; Augustine Kong; Holly J. Wolf; Wilbur A. Franklin; Jose I. Mayordomo; Lambertus A. Kiemeney; Steinn Jonsson

Genome-wide association studies (GWAS) have identified 3 genomic regions, at 15q24-25.1, 5p15.33, and 6p21.33, which associate with the risk of lung cancer. Large meta-analyses of GWA data have failed to find additional associations of genome-wide significance. In this study, we sought to confirm 7 variants with suggestive association to lung cancer (P < 10(-5)) in a recently published meta-analysis. In a GWA dataset of 1,447 lung cancer cases and 36,256 controls in Iceland, 3 correlated variants on 15q15.2 (rs504417, rs11853991, and rs748404) showed a significant association with lung cancer, whereas rs4254535 on 2p14, rs1530057 on 3p24.1, rs6438347 on 3q13.31, and rs1926203 on 10q23.31 did not. The most significant variant, rs748404, was genotyped in an additional 1,299 lung cancer cases and 4,102 controls from the Netherlands, Spain, and the United States and the results combined with published GWAS data. In this analysis, the T allele of rs748404 reached genome-wide significance (OR = 1.15, P = 1.1 × 10(-9)). Another variant at the same locus, rs12050604, showed association with lung cancer (OR = 1.09, 3.6 × 10(-6)) and remained significant after adjustment for rs748404 and vice versa. rs748404 is located 140 kb centromeric of the TP53BP1 gene that has been implicated in lung cancer risk. Two fully correlated, nonsynonymous coding variants in TP53BP1, rs2602141 (Q1136K) and rs560191 (E353D) showed association with lung cancer in our sample set; however, this association did not remain significant after adjustment for rs748404. Our data show that 1 or more lung cancer risk variants of genome-wide significance and distinct from the coding variants in TP53BP1 are located at 15q15.2.


Nature Communications | 2017

A genome-wide association study yields five novel thyroid cancer risk loci

Julius Gudmundsson; Gudmar Thorleifsson; Jon K. Sigurdsson; Lilja Stefansdottir; Jon G. Jonasson; Sigurjon A. Gudjonsson; Daniel F. Gudbjartsson; Gisli Masson; Hrefna Johannsdottir; Gisli H. Halldorsson; Simon N. Stacey; Hannes Helgason; Patrick Sulem; Leigha Senter; Huiling He; Sandya Liyanarachchi; Matthew D. Ringel; Esperanza Aguillo; Angeles Panadero; Enrique Prats; Almudena Garcia-Castaño; Ana de Juan; Fernando Rivera; Li Xu; Lambertus A. Kiemeney; Gudmundur I. Eyjolfsson; Olof Sigurdardottir; Isleifur Olafsson; Kristvinsson H; Romana T. Netea-Maier

The great majority of thyroid cancers are of the non-medullary type. Here we report findings from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patients and 287,550 controls from five study groups of European descent. Our results yield five novel loci (all with Pcombined<3 × 10−8): 1q42.2 (rs12129938 in PCNXL2), 3q26.2 (rs6793295 a missense mutation in LRCC34 near TERC), 5q22.1 (rs73227498 between NREP and EPB41L4A), 10q24.33 (rs7902587 near OBFC1), and two independently associated variants at 15q22.33 (rs2289261 and rs56062135; both in SMAD3). We also confirm recently published association results from a Chinese study of a variant on 5p15.33 (rs2736100 near the TERT gene) and present a stronger association result for a moderately correlated variant (rs10069690; OR=1.20, P=3.2 × 10−7) based on our study of individuals of European ancestry. In combination, these results raise several opportunities for future studies of the pathogenesis of thyroid cancer.


Molecular Psychiatry | 2016

A rare missense mutation in CHRNA4 associates with smoking behavior and its consequences

Thorgeir E. Thorgeirsson; Stacy Steinberg; G. W. Reginsson; Gyda Bjornsdottir; Thorunn Rafnar; Ingileif Jonsdottir; Anna Helgadottir; Solveig Gretarsdottir; Hafdis T. Helgadottir; Steinn Jonsson; Stefan E. Matthiasson; Thorarinn Gislason; Thorarinn Tyrfingsson; Tomas Gudbjartsson; Helgi J. Ísaksson; H. Hardardottir; A. Sigvaldason; Lambertus A. Kiemeney; Aage Haugen; Shanbeh Zienolddiny; Holly J. Wolf; Wilbur A. Franklin; Angeles Panadero; Jose I. Mayordomo; Ian P. Hall; Eva Rönmark; Bo Lundbäck; Asger Dirksen; Haseem Ashraf; Jesper Holst Pedersen

Using Icelandic whole-genome sequence data and an imputation approach we searched for rare sequence variants in CHRNA4 and tested them for association with nicotine dependence. We show that carriers of a rare missense variant (allele frequency=0.24%) within CHRNA4, encoding an R336C substitution, have greater risk of nicotine addiction than non-carriers as assessed by the Fagerstrom Test for Nicotine Dependence (P=1.2 × 10−4). The variant also confers risk of several serious smoking-related diseases previously shown to be associated with the D398N substitution in CHRNA5. We observed odds ratios (ORs) of 1.7–2.3 for lung cancer (LC; P=4.0 × 10−4), chronic obstructive pulmonary disease (COPD; P=9.3 × 10−4), peripheral artery disease (PAD; P=0.090) and abdominal aortic aneurysms (AAAs; P=0.12), and the variant associates strongly with the early-onset forms of LC (OR=4.49, P=2.2 × 10−4), COPD (OR=3.22, P=2.9 × 10−4), PAD (OR=3.47, P=9.2 × 10−3) and AAA (OR=6.44, P=6.3 × 10−3). Joint analysis of the four smoking-related diseases reveals significant association (P=6.8 × 10−5), particularly for early-onset cases (P=2.1 × 10−7). Our results are in agreement with functional studies showing that the human α4β2 isoform of the channel containing R336C has less sensitivity for its agonists than the wild-type form following nicotine incubation.


Human Molecular Genetics | 2016

Insertion of an SVA-E retrotransposon into the CASP8 gene is associated with protection against prostate cancer.

Simon N. Stacey; Birte Kehr; Julius Gudmundsson; Florian Zink; Aslaug Jonasdottir; Sigurjon A. Gudjonsson; Asgeir Sigurdsson; Bjarni V. Halldórsson; Bjarni A. Agnarsson; Kristrun R. Benediktsdottir; Katja K. Aben; Sita H. Vermeulen; Ruben G. Cremers; Angeles Panadero; Brian T. Helfand; Phillip R. Cooper; Jenny Donovan; Freddie C. Hamdy; Viorel Jinga; Ichiro Okamoto; Jon G. Jonasson; Laufey Tryggvadottir; Hrefna Johannsdottir; Anna M. Kristinsdottir; Gisli Masson; Olafur T. Magnusson; Paul D. Iordache; Agnar Helgason; Hannes Helgason; Patrick Sulem

Transcriptional and splicing anomalies have been observed in intron 8 of the CASP8 gene (encoding procaspase-8) in association with cutaneous basal-cell carcinoma (BCC) and linked to a germline SNP rs700635. Here, we show that the rs700635[C] allele, which is associated with increased risk of BCC and breast cancer, is protective against prostate cancer [odds ratio (OR) = 0.91, P = 1.0 × 10−6]. rs700635[C] is also associated with failures to correctly splice out CASP8 intron 8 in breast and prostate tumours and in corresponding normal tissues. Investigation of rs700635[C] carriers revealed that they have a human-specific short interspersed element-variable number of tandem repeat-Alu (SINE-VNTR-Alu), subfamily-E retrotransposon (SVA-E) inserted into CASP8 intron 8. The SVA-E shows evidence of prior activity, because it has transduced some CASP8 sequences during subsequent retrotransposition events. Whole-genome sequence (WGS) data were used to tag the SVA-E with a surrogate SNP rs1035142[T] (r2 = 0.999), which showed associations with both the splicing anomalies (P = 6.5 × 10−32) and with protection against prostate cancer (OR = 0.91, P = 3.8 × 10−7).


Human Molecular Genetics | 2011

European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene

Thorunn Rafnar; Sita H. Vermeulen; Patrick Sulem; Gudmar Thorleifsson; Katja K. Aben; J. Alfred Witjes; Anne J. Grotenhuis; Gerald W. Verhaegh; Christina A. Hulsbergen-van de Kaa; Søren Besenbacher; Daniel F. Gudbjartsson; Simon N. Stacey; Julius Gudmundsson; Hrefna Johannsdottir; Hjordis Bjarnason; Carlo Zanon; Hafdis T. Helgadottir; Jon G. Jonasson; Laufey Tryggvadottir; Eirikur Jonsson; Gudmundur Geirsson; Sigfus Nikulasson; Vigdis Petursdottir; D. Timothy Bishop; Sei Chung-Sak; Ananya Choudhury; Faye Elliott; Jennifer H. Barrett; Margaret A. Knowles; Petra J. de Verdier

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Katja K. Aben

Radboud University Nijmegen

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Sita H. Vermeulen

Radboud University Nijmegen

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