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Featured researches published by Angelo Guttadauro.


Diseases of The Colon & Rectum | 2000

Hemorrhoidectomy with posterior perineal block: experience with 400 cases.

Francesco Gabrielli; Ugo Cioffi; Marco Chiarelli; Angelo Guttadauro; Matilde De Simone

PURPOSE: The aim of this study was to evaluate the advantages and feasibility of hemorrhoidectomy using regional anesthesia (posterior perineal block). METHODS: From March 1994 to December 1998 we performed 400 hemorrhoidectomies with regional anesthesia in an overnight-stay regimen in our department (Colo-Rectal Unit). Posterior perineal block involves anesthesia of the deep plains (infiltration of the inferior hemorrhoidal nerves, the posterior branch of the internal pudendal nerves, and the anococcygeal nerves) and anesthesia of the superficial plains (block of the inferior gluteal nerves and of perineal branches of minor nerves from the sacral plexus). RESULTS: Posterior perineal block was always effective; optimal to satisfactory intraoperative analgesia was obtained in 379 patients (95.2 percent), whereas in 17 cases (4.2 percent) intravenous analgesic drugs were administered. No conversion to general anesthesia was needed. Urinary retention was 7.8 percent. In our study most of patients (70 percent) reported no pain at all for five to ten hours. Ninety-two percent of patients were discharged in the first 24 hours. CONCLUSIONS: Posterior perineal block allows the surgeon to perform radical hemorrhoidectomies in an overnight-stay regimen with safe and effective intraoperative and postoperative analgesia, sphincter relaxation, and low incidence of urinary retention. Experience of the surgeon combined with careful surgical handling are of great importance for success in this technique.


Diseases of The Colon & Rectum | 2001

Day surgery for mucosal-hemorrhoidal prolapse using a circular stapler and modified regional anesthesia.

Francesco Gabrielli; Marco Chiarelli; Ugo Cioffi; Angelo Guttadauro; Matilde De Simone; Piero Di Mauro; Alessandro Arriciati

PURPOSE: In 1993, prolapse reduction using the circular stapler for the treatment of hemorrhoidal disease was proposed. The procedure is characterized by minimal postoperative pain. In this study we evaluated the above technique using regional anesthesia to identify the advantages and feasibility of stapled hemorrhoidectomy, with special focus on the efficacy of same-day discharge. METHODS: From December 1997 to November 1999, we performed 70 consecutive reduction corrections of mucosal hemorrhoidal prolapse using the circular stapler with regional anesthesia (a technical modification of Martis posterior perineal block). Our series included 41 males and 29 females with a mean age of 43.4 (range, 25–74) years. Three patients were affected by second-degree hemorrhoids and 67 by third-degree hemorrhoids. RESULTS: Sixty-two patients were discharged three hours after the operation in good general condition and without pain, whereas eight patients were discharged the day after for early complications, consisting of two cases of early bleeding, three cases of urinary retention, and three cases of persistent severe pain requiring prolonged medical treatment. CONCLUSION: Our study shows that, in selected cases, it is possible to perform day surgery for patients with hemorrhoidal disease using a circular stapler device when combined with regional anesthesia.


Ambulatory Surgery | 1998

The problem of pain after day-surgery haemorrhoidectomy

Francesco Gabrielli; Marco Chiarelli; Angelo Guttadauro; Luca Poggi

Abstract A total of 185 patients underwent day surgery haemorrhoidectomy with postoperative discharge after 24 h. An open technique (Milligan-Morgan) was adopted in 177 cases (97.8%) and a closed technique (Ferguson) in 8 cases (2.2%). In all cases, anaesthesia was achieved by the posterior perineal block: effective analgesia was obtained in 52.4% of the cases (very good and good analgesia) and postoperative analgesic effectiveness reached 5–10 h in most patients (49.2%), while in 9.2% of the cases analgesia was effective for up to 15 h or over. Innervation complexity and early wound stimulation make a painless haemorrhoidectomy impossible. It was not found that any particular surgical technique was superior to another. No evident advantages could be found in closed haemorrhoidectomies or laser/diathermic dissection nor was routine internal sphincterotomy found useful. Pain control was mainly entrusted to the action of pharmaceutical agents. In the operating theatre, the posterior perineal block can be followed by long term local anaesthetic or NSAIDs infiltration of muco-cutaneous wounds. During the postoperative period, lasting 30 days, pain assessment is not an easy task but this can be performed by Graphic Rating Scale. Pain at rest was moderate to acute during week 1 in 64.3% of the cases, while being light or absent in 35.7%. By week 2, pain had become moderate to acute in 29.2% of the patients, being light or absent in 70.8%. Finally, by week 3, only 10.8% of the patients reported moderate to acute pain (and this was due to complications ensuing such as haemorrhage or stenosis). Pain intensity increased at defecation, with 86% of the patients reporting acute moderate pain in week 1. A more gradual reduction of pain at evacuation was noted in later weeks compared to that at rest. Only in 2.7% of the cases did we have to resort to major analgesia during the first 24 h. In all other cases, NSAIDs (Ketorolac) sufficed with i.m. injections of 30 mg up to three times a day before discharge and 10 mg orally up to three times a day once the patient had returned home. Effective anaesthesia, competent surgery, a close follow up and regularly administered minor analgesics provide effective postoperative pain control after day surgery haemorrhoidectomy. As a result, the operation is no longer feared, as next to normal physical activity was reported towards the end of week 1 in 94.1% of the cases. Most patients expressed full satisfaction with their treatment 30 days after surgery.


The Annals of Thoracic Surgery | 2015

An Incidental Pulmonary Meningioma Revealing an Intracranial Meningioma: Primary or Secondary Lesion?

Marco Chiarelli; Matilde De Simone; Martino Gerosa; Angelo Guttadauro; Ugo Cioffi

A 68-year-old man underwent a resection of the right middle lobe for a solitary lesion detected at computed tomography. The histologic result was suggestive for a pulmonary meningioma. Although the result of a preoperative brain computed tomography scan was negative, magnetic resonance imaging showed a skull-base meningioma. On the basis of the absence of symptoms, we decided to observe the intracranial meningioma. At 3 years of follow-up, the patient was free of recurrence and the cerebral lesion was stable. Primary pulmonary meningioma and benign meningioma metastasis share identical microscopic findings, and only a central nervous system radiologic study allows their distinction. The pulmonary lesion in our patient was classified as a meningioma metastasis.


World Journal of Emergency Surgery | 2018

2017 WSES guidelines on colon and rectal cancer emergencies: obstruction and perforation

Michele Pisano; Luigi Zorcolo; Cecilia Merli; Stefania Cimbanassi; Elia Poiasina; Marco Ceresoli; Ferdinando Agresta; Niccolò Allievi; Giovanni Bellanova; Federico Coccolini; Claudio Coy; Paola Fugazzola; Carlos Augusto Real Martinez; Giulia Montori; Ciro Paolillo; Thiago Josè Penachim; Bruno M. Pereira; Tarcisio Reis; Angelo Restivo; Joao Rezende-Neto; Massimo Sartelli; Massimo Valentino; Fikri M. Abu-Zidan; Itamar Ashkenazi; Miklosh Bala; Osvaldo Chiara; Nicola de’Angelis; Simona Deidda; Belinda De Simone; Salomone Di Saverio

AbstractᅟObstruction and perforation due to colorectal cancer represent challenging matters in terms of diagnosis, life-saving strategies, obstruction resolution and oncologic challenge. The aims of the current paper are to update the previous WSES guidelines for the management of large bowel perforation and obstructive left colon carcinoma (OLCC) and to develop new guidelines on obstructive right colon carcinoma (ORCC).MethodsThe literature was extensively queried for focused publication until December 2017. Precise analysis and grading of the literature has been performed by a working group formed by a pool of experts: the statements and literature review were presented, discussed and voted at the Consensus Conference of the 4th Congress of the World Society of Emergency Surgery (WSES) held in Campinas in May 2017.ResultsCT scan is the best imaging technique to evaluate large bowel obstruction and perforation. For OLCC, self-expandable metallic stent (SEMS), when available, offers interesting advantages as compared to emergency surgery; however, the positioning of SEMS for surgically treatable causes carries some long-term oncologic disadvantages, which are still under analysis. In the context of emergency surgery, resection and primary anastomosis (RPA) is preferable to Hartmann’s procedure, whenever the characteristics of the patient and the surgeon are permissive. Right-sided loop colostomy is preferable in rectal cancer, when preoperative therapies are predicted.With regards to the treatment of ORCC, right colectomy represents the procedure of choice; alternatives, such as internal bypass and loop ileostomy, are of limited value.Clinical scenarios in the case of perforation might be dramatic, especially in case of free faecal peritonitis. The importance of an appropriate balance between life-saving surgical procedures and respect of oncologic caveats must be stressed. In selected cases, a damage control approach may be required.Medical treatments including appropriate fluid resuscitation, early antibiotic treatment and management of co-existing medical conditions according to international guidelines must be delivered to all patients at presentation.ConclusionsThe current guidelines offer an extensive overview of available evidence and a qualitative consensus regarding management of large bowel obstruction and perforation due to colorectal cancer.


Journal of Thoracic Disease | 2017

Chylothorax after mediastinal ganglioneuroma resection treated with fibrin sealant patch: a case report

Marco Chiarelli; Pietro Achilli; Angelo Guttadauro; Giuseppe Vertemati; Sabina Terragni; Matilde De Simone; Ugo Cioffi

Chylothorax is a severe condition resulting from the accumulation of chyle into the pleural space. We report the treatment of postoperative chylothorax after resection of mediastinal ganglioneuroma in a 17-year-old boy. Since conservative measures were not effective, we performed direct ligation of lymphatic vessels and pleurodesis. At subsequent surgical re-exploration for persisting chylothorax, accurate inspection of pleural cavity revealed residual chyle leakage. Fibrin sealant patches (TachoSil®) were placed over the source of leak with complete resolution of chylous effusion. To our knowledge, this is the first report of postoperative chylothorax successfully treated by the use of a fibrin sealant patch.


Journal of Thoracic Disease | 2016

Urgent pulmonary lobectomy for blunt chest trauma: report of three cases without mortality.

Marco Chiarelli; Martino Gerosa; Angelo Guttadauro; Francesco Gabrielli; Giuseppe Vertemati; Massimo Cazzaniga; Luca Fumagalli; Matilde De Simone; Ugo Cioffi

BACKGROUND The majority of patients with severe blunt chest trauma is successfully treated with supportive measures and thoracostomy tube; only few cases need urgent thoracotomy. Lung-sparing techniques are treatments of choice but major pulmonary resections are necessary in case of injuries involving hilar vessels or bronchi. Currently the mortality associated with pulmonary lobectomy performed for chest trauma is 40%. METHODS Over a 2-year period [2013-2014], 210 patients with chest trauma were hospitalized at our Institution. Mechanism of injury was blunt in 204 (97.1%) patients and penetrating in 6 (2.9%). In 48 (22.8%) patients was necessary a ventilatory support and 37 (17.6%) patients were treated with thoracostomy tube. Nineteen (9%) patients needed urgent thoracotomy: 4 (1.9%) cases for penetrating injury and 15 (7.1%) cases for blunt trauma. Three (1.4%) patients treated with urgent thoracotomy required concomitant laparotomy for intra-abdominal injuries. The overall mortality rate was 1.4%. RESULTS We report three cases of urgent lobectomies for chest trauma without mortality and with postoperative complete restoration of respiratory function. The anatomical lobectomies were performed for: massive hemothorax with bronchial disruption, expanding pulmonary hematoma with hypovolemic shock, and massive hemothorax in deep parenchymal laceration. CONCLUSIONS Mortality rate after major pulmonary resections for trauma is very high and increases with the presence of multivisceral injuries, the severity of hypovolemic shock and extent of lung resection. Anterolateral thoracotomy was the approach employed in case of cardiac arrest. In hypovolemic patients a posterolateral incision with a double lumen intubation was performed. The absence of mortality in this series may be related to the prompt diagnosis, short operative time and absence of associated severe neurological or abdominal injuries.


Diseases of The Colon & Rectum | 2015

Circumferential anal giant condyloma acuminatum: a new surgical approach.

Angelo Guttadauro; Marco Chiarelli; Daniele Macchini; Silvia Frassani; Matteo Maternini; Aimone Bertolini; Francesco Gabrielli

INTRODUCTION: Perianal giant condyloma acuminatum is a rare clinical condition related to human papillomavirus infection and characterized by a circumferential, exophytic, cauliflower-like mass with an irregular warty surface localized in the anal region. TECHNIQUE: A circular incision with a diathermocoagulator was performed on macroscopically healthy skin, 1 cm from the margin of the lesion. The dermis was divided from the subcutaneous tissue. This way, a mucocutaneous cylinder including the whole lesion was obtained. A median radial incision was carried out to open the cylinder at its front. A progressive circumferential section on healthy mucosa (≈1 cm above the margin of the lesion) by means of a radiofrequency dissector allowed for the complete removal of the mass. The healthy mucosa of the anal canal was pulled out by Allis forceps and was sutured to the external margin of the internal sphincter with single layer of Vicryl (polyglactin 910) 2-0 sutures. RESULTS: Two months after surgery, no findings of anal stenosis or mucosal ectropion were reported. At the 1-year follow-up there was no recurrence of condylomatosis in any of the 3 cases. CONCLUSIONS: Our procedure seems simpler to perform when compared with other techniques and reduces hospital stay and complications such as anal stenosis and mucosal ectropion.


Archive | 2018

Surgical Management of Full-Thickness Rectal Prolapse in the Elderly Patient

Francesco Gabrielli; Angelo Guttadauro; Matteo Maternini; Nicoletta Pecora

The incidence of full-thickness rectal prolapse is 1% in patients over 65 years of age. Risk factors are multiparity, previous pelvic surgery, and neurological or psychiatric disorders. IBS, constipation, and chronic straining are comorbidity factors. Symptoms and risk of complications are indications for surgical treatment. Among abdominal operations, ventral rectopexy recently seems to offer the best long-term results. Recurrence rate less than 3–4%, a net improvement of continence, is in up to 80–90% of cases; compared with traditional rectopexies, a greater improvement in constipation and a reduced risk of postoperative constipation are observed. Perineal procedures (Altemeier’s proctosigmoidectomy) are less demanding on the patients and are still the favorite technical choice in the elderly, mostly in high-risk patients. Morbidity and mortality are low and postoperative recovery is faster. If the technique is correctly performed, there seems to be no statistically significant difference in recurrence rate between abdominal and perineal procedures. However, in the last few years, there is a new emerging trend for a wider use of laparoscopic ventral rectopexy also in geriatric low-risk patients.


BMC Gastroenterology | 2018

Wirsung atraumatic rupture in patient with pancreatic pseudocysts: a case presentation

Martino Gerosa; Marco Chiarelli; Angelo Guttadauro; Matilde De Simone; Fulvio Tagliabue; Melchiorre Costa; Sabina Terragni; Ugo Cioffi

BackgroundPancreatic duct disruption is a challenging condition leading to pancreatic juice leakage and consequently to pancreatic fluid collections. The manifestations of pancreatic main duct leak include pseudocysts, walled-off necrosis, pancreatic fistulas, ascites, pleural and pericardial effusions. Pseudocyst formation is the most frequent outcome of a pancreatic duct leak.Case presentationWe describe a case of a 64-year old man with large multiple pancreatic cysts discovered for progressive jaundice and significant weight loss in the absence of a previous episode of acute pancreatitis. Computed tomography scan showed lesion with thick enhancing walls. The main cyst dislocated the stomach and the duodenum inducing intra and extrahepatic bile ducts enlargement. Magnetic resonance cholangiopancreatography revealed a communication between the main pancreatic duct and the cystic lesions due to Wirsung duct rupture. Endoscopic ultrasound guided fine needle aspiration cytology did not show neoplastic cells and cyst fluid analysis revealed high amylase concentration. Preoperative exams were suggestive but not conclusive for a benign lesion. Laparotomy was necessary to confirm the presence of large communicating pseudocysts whose drainage was performed by cystogastrostomy. Histology confirmed the inflammatory nature of the cyst wall. Subsequently, the patient had progressive jaundice resolution.ConclusionPancreatic cystic masses include several pathological entities, ranging from benign to malignant lesions. Rarely pseudocysts present as complex cystic pancreatic lesions with biliary compression in absence of history of acute pancreatitis. We describe the rare case of multiple pancreatic pseudocysts due to Wirsung duct rupture in absence of previous trauma or acute pancreatitis. Magnetic resonance showed the presence of communication with the main pancreatic duct and endoscopic ultrasound fine needle aspiration suggested the benign nature of the lesion.

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Luca Fumagalli

University of Milano-Bicocca

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Pietro Achilli

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

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Silvia Frassani

University of Milano-Bicocca

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