Angelo Pizzigallo

Health-related quality of life as a survival predictor for patients with oral cancer: is quality of life associated with long-term overall survival?

OBJECTIVE The aim of the present prospective study was to obtain further insight into health-related quality of life (HR-QoL) as a predictor of survival in a selected cohort of patients with oral cancer. STUDY DESIGN A total of 124 patients were treated with surgery or combined therapy. All of the recruited patients completed the European Organization for Research and Treatment of Cancer questionnaires QLQC30 and H&N35 on 4 occasions. Overall survival was assessed. Univariate and multivariate Cox proportional hazards regression models were conducted. RESULTS High baseline HR-QoL score and high pain symptom score were significantly associated with a better survival (HR 0.86 and 0.92 respectively). Swallowing (HR 0.94), and speech (HR 0.92) high baseline scores were also significantly associated with a better survival in the adjusted analyses. CONCLUSIONS Patients who reported a better HR-QoL at tumor diagnosis had a better survival than patients with a lower HR-QoL baseline score.

Does microvascular free flap reconstruction in oral squamous cell carcinoma improve patient survival

Objective We analyzed our experiences with microvascular reconstruction after oncologic resections for oral squamous cell carcinoma. Has microvascular surgery changed the survival rate of these patients? Design Retrospective study. Subjects and Methods Forty-two consecutive patients enrolled from March 1999 to December 2004. Follow-up time ranged from 1 to 94 months. Survival rates were evaluated by the Kaplan-Meier method and compared among different groups with the use of Cox regression. Results The actuarial 5-year survival rate was 41.9% (SD = 9.6%). Survival rates were also analyzed according to T, N, and stage. The survival was significantly related only to N, which showed a 72.4% increase in the risk related to the increase of one N stage. Conclusions A comparison between our study group and those of 3 previous similar studies would not provide definitive statistical evidence, but it could certainly suggest a trend. The comparison seems to support that microvascular free tissue transfer does not change the survival of these patients.

Computer-Aided Rehabilitation of Maxillary Oncological Defects Using Zygomatic Implants: A Defect-Based Classification

PURPOSE A complete maxillectomy for neoplastic lesions leads to serious oral dysfunction. Zygomatic implants for fixed bridge support are considered beneficial for maxillary defects after tumor resection. MATERIALS AND METHODS This clinical study examined the management of patients with different maxillary defect types who underwent delayed rehabilitation using zygomatic implants and immediate prosthetic loading. Virtual preoperative planning and intraoperative navigation were performed in all cases. RESULTS Five patients were treated with this new method. The total number of zygomatic implants positioned was 17. Four patients had immediate loading of a fixed prosthesis and 1 had delayed loading. One patient had 1 failed implant. CONCLUSION The use of preoperative virtual surgical planning and an intraoperative navigation system allows the surgeon to achieve safer implant positioning in a complex anatomic site. A systematic bone defect classification was created and a specific treatment protocol is proposed for each type of defect.

Orbital Reconstruction: Patient-Specific Orbital Floor Reconstruction Using a Mirroring Technique and a Customized Titanium Mesh.

Objective:Enophthalmos is a severe complication of primary reconstruction of orbital floor fractures. The goal of secondary reconstruction procedures is to restore symmetrical globe positions to recover function and aesthetics. The authors propose a new method of orbital floor reconstruction using a mirroring technique and a customized titanium mesh, printed using a direct metal laser-sintering method. Methods:This reconstructive protocol involves 4 steps: mirroring of the healthy orbit at the affected site, virtual design of a patient-specific orbital floor mesh, CAM procedures for direct laser-sintering of the customized titanium mesh, and surgical insertion of the device. Using a computed tomography data set, the normal, uninjured side of the craniofacial skeleton was reflected onto the contralateral injured side, and a reconstructive orbital floor mesh was designed virtually on the mirrored orbital bone surface. The solid-to-layer files of the mesh were then manufactured using direct metal laser sintering, which resolves the shaping and bending biases inherent in the indirect method. An intraoperative navigation system ensured accuracy of the entire procedure. Results:Clinical outcomes were assessed using 3dMD photogrammetry and computed tomography data in 7 treated patients. Conclusion:The technique described here appears to be a viable method to correct complex orbital floor defects needing delayed reconstruction. This study represents the first step in the development of a wider experimental protocol for orbital floor reconstruction using computer-assisted design-computer-assisted manufacturing technology.

Intraoperative biopsy of the major cranial nerves in the surgical strategy for adenoid cystic carcinoma close to the skull base

OBJECTIVE Adenoid cystic carcinoma of the salivary glands has a propensity for perineural invasion, which could favor spread along the major cranial nerves, sometimes to the skull base and through the foramina to the brain parenchyma. This study evaluated the relationship between neural spread and relapse in the skull base. STUDY DESIGN During surgery, we performed multiple biopsies with extemporaneous examination of the major nerves close to the tumor to guide the surgical resection. RESULTS The percentage of actuarial local control at 5 years for patients with a positive named nerve and skull base infiltration was 12.5%, compared with 90.0% in patients who were named nerve-negative and without infiltration of the skull base (P = .001). CONCLUSIONS Our study shows that local control of disease for patients who are named nerve-positive with skull base infiltration is significantly more complex compared with patients who are named nerve-negative without infiltration of the skull base.

“Hammock” reconstruction of full-thickness excised lower lip: a case report

A number of techniques have been described to reconstruct lower lip defects. A microsurgical total lower lip reconstruction was performed in a 48-year-old female patient affected by a squamous cell carcinoma of the lower lip. The patient underwent a wide lower lip resection and an immediate aesthetic and functional lower lip reconstruction. The lower lip was reconstructed with a composite radial forearm palmaris longus flap. The subcutaneous layer of the residual upper lip was undermined and palmaris longus tendon was transfixed to the paranasal portion of the orbicularis oris muscle, giving to the flap a good aesthetic “hammock” effect and achieving a nearly impairment free function. The use of a forearm free flap for lower lip reconstruction has previously been described, with poor functional results. We have described a different technique to inset and fix the flap using palmaris longus tendon: the suspension vector of the flap and the preservation of the residual orbicularis oris fibers seem to be of great importance to achieve a satisfactory functional recovery. We propose that the radial forearm free flap comprising palmaris longus tendon, inset and fixed with the described technique, may be a good alternative among the surgical options for full-thickness lower lip defects in order to achieve a satisfactory aesthetic and functional reconstruction.