Anh-Dung Nguyen

Intratester and Intertester Reliability of Clinical Measures of Lower Extremity Anatomic Characteristics: Implications for Multicenter Studies

ObjectiveTo determine whether multiple examiners could be trained to measure lower extremity anatomic characteristics with acceptable reliability and precision, both within (intratester) and between (intertester) testers. We also determined whether testers trained 18 months apart could perform these measurements with good agreement. SettingUniversitys Applied Neuromechanics Research Laboratory. ParticipantsSixteen, healthy participants (7 men, 9 women). Assessment of Risk FactorsSix investigators measured 12 anatomic characteristics on the right lower extremity in the Fall of 2004. Four testers underwent training immediately preceding the study, and measured subjects on 2 separate days to examine intratester reliability. Two testers trained 18 months before the study (Spring 2002) measured each subject on day 1 to examine the consistency of intertester reliability when testers are trained at different times. Main Outcome MeasurementsKnee laxity, genu recurvatum, quadriceps angle, tibial torsion, tibiofemoral angle, hamstring extensibility, pelvic angle, navicular drop, femur length, tibial length, and hip anteversion. ResultsWith few exceptions, all testers consistently measured each variable between test days (intraclass correlation coefficient≥0.80). Intraclass correlation coefficient values were lower for intertester reliability (0.48 to 0.97), and improved from day 1 to day 2. Intertester reliability was similar when comparing testers trained 18 months before those trained immediately before the study. Absolute measurement error varied considerably across individual testers. ConclusionsMultiple investigators can be trained at different times to measure anatomic characteristics with good to excellent intratester reliability. Intratester reliability did not always ensure acceptable intertester reliability or measurement precision, suggesting more training (or more experience) may be required to achieve acceptable measurement reliability and precision between multiple testers.

Thigh Strength and Activation as Predictors of Knee Biomechanics during a Drop Jump Task

PURPOSE To examine whether normalized quadriceps and hamstring strength would predict quadriceps and hamstring muscle activation amplitudes and whether these neuromuscular factors would predict knee kinematics and kinetics during a drop jump task. METHODS Thirty-nine females and 39 males were measured for isometric quadriceps and hamstring strength and were instrumented to obtain surface electromyography, kinematic, and kinetic measures during the initial landing of a drop jump. Multiple linear regressions first examined the relationship between thigh strength and activation then examined whether these neuromuscular variables were predictive of hip and knee flexion excursions, knee extensor moments (KEM), and anterior knee shear forces during the deceleration phase of the drop jump. RESULTS Females versus males produced lower normalized thigh strength and demonstrated greater quadriceps and hamstring activation amplitudes during the drop jump. Lower thigh muscle strength was a weak (males) to moderate (females) predictor of greater quadriceps activation amplitudes. However, thigh strength and activation were poor predictors of hip and knee joint excursions and KEM. Regardless of sex and thigh strength, anterior shear forces were greater in individuals who demonstrated less hip flexion and greater knee flexion excursions and greater peak quadriceps activation and internal KEM during the landing. CONCLUSIONS Although thigh muscle strength explained some of the variance in quadriceps and hamstring activation levels as measured with surface electromyography, we failed to support the hypothesis that these neuromuscular factors are strong predictors of sagittal plane hip and knee flexion excursions or KEM. Although greater quadriceps activation amplitude was a significant predictor of greater anterior tibial shear forces, its contribution was relatively small compared with kinematic and kinetic variables.

Varus/Valgus and Internal/External Torsional Knee Joint Stiffness Differs between Sexes

Background Torsional joint stiffness is thought to play a role in the observed sex bias in noncontact anterior cruciate ligament injury rates. Hypothesis Women will exhibit lower torsional stiffness values of the knee in response to varus/valgus and internal/external rotations than will men. Study Design Controlled laboratory study. Methods Knee kinematics of 20 university students (10 men, 27.3 ± 3.4 years, 177.3 ± 6.8 cm, 81.1 ± 7.0 kg; 10 women, 22.9 ± 1.5 years, 169.0 ± 7.1 cm, 66.1 ±11.4 kg) were measured while 0 to 10 Nm of varus and valgus torques were applied with the subject nonweightbearing and while 0 to 5 N.m of internal and external torques were applied with the subject nonweightbearing and weightbearing with the use of a custom joint testing device. Joint stiffness values were calculated at 1-N.m increments. Results When low magnitudes of torque were applied to the knee, women had significantly lower stiffness values than did men-With the exception of applied external torque with the joint weightbearing and varus torque with the joint nonweightbearing, women demonstrated an increase in joint stiffness as the magnitude of torque increased from lower to higher magnitudes. In contrast, for the men, joint stiffness values remained unchanged as the magnitude of applied torque increased. Conclusion Women exhibited lower knee stiffness in response to low magnitudes of applied torque compared to men and demonstrated an increase of joint stiffness as the magnitude of applied torque increased. Clinical Relevance The decreased stiffness behavior of the knee in response to low torques that was observed for women may have a role in detrimentally affecting knee biomechanics and resulting neuromuscular function, particularly when an individual transitions from nonweightbearing to weightbearing.

Dynamic Valgus Alignment and Functional Strength in Males and Females During Maturation

CONTEXT Sex differences in dynamic measures have been established in physically mature populations. Gaining information on maturations effect on dynamic performance measures implicated in injury risk may enable us to better design injury prevention programs. OBJECTIVE To examine sex differences in dynamic valgus alignment and triple-hop distance measures across maturational stages in males and females. A secondary purpose was to determine if a field test of strength and power predicts dynamic valgus alignment. DESIGN Cross-sectional study. SETTING Laboratory. PATIENTS OR OTHER PARTICIPANTS 157 young athletes (78 females, 79 males) aged 9 to 18 years. INTERVENTION(S) Subjects performed drop-jump landings and single-leg triple-hop tests as part of a broader injury screening. MAIN OUTCOME MEASURE(S) Maturational status was ascertained from self-report questionnaires and grouped according to Tanner stages 1 and 2 (MatGrp1), 3 and 4 (MatGrp2), and 5 (MatGrp3). Frontal-plane knee valgus displacement, which served as a measure of dynamic valgus alignment, and single-leg triple-hop distance were assessed. RESULTS Males demonstrated less dynamic valgus alignment during drop jumps in the latter maturational stages (MatGrp1 = 13.1 degrees +/- 8.7 degrees , MatGrp2 = 9.0 degrees +/- 6.2 degrees , MatGrp3 = 9.2 degrees +/- 9.4 degrees ), whereas females increased dynamic valgus alignment throughout maturation (MatGrp1 = 11.5 degrees +/- 6.9 degrees , MatGrp2 = 12.8 degrees +/- 8.8 degrees , MatGrp3 = 15.5 degrees +/- 8.7 degrees ). Thus, in the more mature groups, males had less dynamic valgus alignment than females. Both males (MatGrp1 = 393.5 +/- 63.7 cm, MatGrp2 = 491.8 +/- 95.1 cm, MatGrp3 = 559.3 +/- 76.3 cm) and females (MatGrp1 = 360.3 +/- 37.1 cm, MatGrp2 = 380.1 +/- 44.3 cm, MatGrp3 = 440.0 +/- 66.2 cm) increased triple-hop distance, but males increased more. Within each subgroup of MatGrp and sex, triple-hop distance had no predictive ability for dynamic malalignment. CONCLUSIONS When dynamic valgus alignment and strength were assessed, sex and maturational status displayed an interaction. However, functional strength did not predict degree of dynamic valgus alignment.

Joint laxity is related to lower extremity energetics during a drop jump landing.

PURPOSE To examine the relationships between anterior knee laxity (AKL), genu recurvatum (GR), and general joint laxity (GJL) with sagittal plane energetics in males and females during a drop jump task. METHODS A total of 68 females and 50 males were measured for AKL, GR, and GJL and were instrumented to obtain neuromuscular and biomechanical data on their dominant limb during the initial landing phase of a 45-cm drop jump. Multiple linear regressions determined the extent to which the three joint laxity variables combined to predict hip, knee, and ankle work absorption and stiffness. Associations between joint laxity and joint kinematics, joint kinetics, and muscle activation amplitudes were also investigated to further interpret significant relationships. RESULTS Higher AKL and GJL and lower GR combined to predict greater knee work absorption (R2 = 0.210, P = 0.002) and stiffness (R2 = 0.127, P = 0.033) and lower ankle stiffness (R2 = 0.115, P = 0.048) in females. These associations were modulated through greater peak knee extensor moments and flexion angles, lower hamstring activation, and lower ankle extensor moments. In males, joint laxity had little impact on knee energetics, but a significant association was observed between greater GJL and decreased ankle stiffness (R2 = 0.209, P = 0.012), a product of both greater peak ankle flexion and decreased ankle extensor moment. CONCLUSIONS Females with greater AKL and GJL and lower GR demonstrated a landing strategy that increased work absorption and stiffness about the knee, whereas females with greater GR demonstrated a landing style that reduced knee work absorption and stiffness. The findings suggest that AKL, GR, and GJL may represent distinct risk factors and support the need to consider more comprehensive laxity profiles as they relate to knee joint function and anterior cruciate ligament injury risk.

A Preliminary Multifactorial Approach Describing the Relationships Among Lower Extremity Alignment, Hip Muscle Activation, and Lower Extremity Joint Excursion

CONTEXT Multiple factors have been suggested to increase the risk of faulty dynamic alignments that predict noncontact anterior cruciate ligament injury. Few researchers have examined this relationship using an integrated, multifactorial approach. OBJECTIVE To describe the relationship among static lower extremity alignment (LEA), hip muscle activation, and hip and knee motion during a single-leg squat. DESIGN Descriptive laboratory study. SETTING Research laboratory. PATIENTS OR OTHER PARTICIPANTS Thirty men (age= 23.9± 3.6 years, height =178.5± 9.9 cm, mass= 82.0± 14.1 kg) and 30 women (age= 22.2± 2.6 years, height= 162.4± 6.3 cm, mass= 60.3± 8.1 kg). MAIN OUTCOME MEASURE(S) Pelvic angle, femoral anteversion, quadriceps angle, tibiofemoral angle, and genu recurvatum were measured to the nearest degree; navicular drop was measured to the nearest millimeter. The average root mean square amplitude of the gluteus medius and maximus muscles was assessed during the single-leg squat and normalized to the peak root mean square value during maximal contractions for each muscle. Kinematic data of hip and knee were also assessed during the single-leg squat. Structural equation modeling was used to describe the relationships among static LEA, hip muscle activation, and joint kinematics, while also accounting for an individuals sex and hip strength. RESULTS Smaller pelvic angle and greater femoral anteversion, tibiofemoral angle, and navicular drop predicted greater hip internal-rotation excursion and knee external-rotation excursion. Decreased gluteus maximus activation predicted greater hip internal-rotation excursion but decreased knee valgus excursion. No LEA characteristic predicted gluteus medius or gluteus maximus muscle activation during the single-leg squat. CONCLUSIONS Static LEA, characterized by a more internally rotated hip and valgus knee alignment and less gluteus maximus activation, was related to commonly observed components of functional valgus collapse during the single-leg squat. This exploratory analysis suggests that LEA does not influence hip muscle activation in controlling joint motion during a single-leg squat.

Identifying Relationships Among Lower Extremity Alignment Characteristics

CONTEXT The relationship between lower extremity alignment and lower extremity injury risk remains poorly understood, perhaps because most authors have examined only individual or a select group of alignment variables. Examining the relationships among alignment variables may allow us to more accurately describe lower extremity posture and clarify the relationship between lower extremity alignment and injury risk in future studies. OBJECTIVE To measure lower extremity alignment variables and examine whether relationships could be identified among these variables. DESIGN Observational study. SETTING Laboratory. PATIENTS OR OTHER PARTICIPANTS Two hundred eighteen (102 males: age = 23.1 +/- 3.2 years, height = 177.3 +/- 8.4 cm, mass = 80.8 +/- 13.0 kg; 116 females: age = 21.8 +/- 2.7 years, height = 163.5 +/- 7.4 cm, mass = 63.4 +/- 12.4 kg) healthy, college-aged participants. MAIN OUTCOME MEASURE(S) We measured pelvic angle, femoral anteversion, quadriceps angle, tibiofemoral angle, genu recurvatum, and tibial torsion to the nearest degree and navicular drop to the nearest millimeter on the right and left lower extremities. Separate principal components factor analyses were performed for each sex and side (left, right). RESULTS A distinct lower extremity factor was identified, with relationships observed among increased pelvic angle, increased quadriceps angle, and increased tibiofemoral angle. A second distinct lower extremity factor was identified, with relationships observed among increased supine genu recurvatum, decreased tibial torsion, and increased navicular drop. Femoral anteversion loaded as an independent third factor. These distinct lower extremity alignment factors were consistent across side and sex. CONCLUSIONS Factor analysis identified 3 distinct lower extremity alignment factors that describe the potential interactions among lower extremity alignment variables. Future authors should examine how these collective alignment variables, both independently and in combination, influence dynamic knee function and risk for lower extremity injuries.

Relationships Between Lower Extremity Alignment and the Quadriceps Angle

Objective:To determine the extent to which select lower extremity alignment characteristics of the pelvis, hip, knee, and foot are related to the Q angle. Design:Descriptive cohort study design. Setting:Applied Neuromechanics Research Laboratory. Participants:Two hundred eighteen participants (102 males, 116 females). Assessment of Risk Factors:Eight clinical measures of static alignment of the left lower extremity were measured by a single examiner to determine the impact of lower extremity alignment on the magnitude of Q angle. Main Outcome Measures:Q angle, pelvic angle, hip anteversion, tibiofemoral angle, genu recurvatum, tibial torsion, navicular drop, and femur and tibia length. Results:Once all alignment variables were accounted for, greater tibiofemoral angle and femoral anteversion were significant predictors of greater Q angle in both males and females. Pelvic angle, genu recurvatum, tibial torsion, navicular drop, and femur to tibia length ratio were not significant independent predictors of Q angle in males or females. Conclusions:Greater femoral anteversion and tibiofemoral angle result in greater Q angle, with changes in tibiofemoral angle having a substantially greater impact on the magnitude of the Q angle compared with femoral anteversion. As such, the Q angle seems to largely represent a frontal plane alignment measure. As many knee injuries seem to result from a combination of both frontal and transverse plane motions and forces, this may in part explain why Q angle has been found to be a poor independent predictor of lower extremity injury risk.

A Comparison of Cyclic Variations in Anterior Knee Laxity, Genu Recurvatum and General Joint Laxity across the Menstrual Cycle

Changes in anterior knee laxity (AKL), genu recurvatum (GR) and general joint laxity (GJL) were quantified across days of the early follicular and early luteal phases of the menstrual cycle in 66 females, and the similarity in their pattern of cyclic variations examined. Laxity was measured on each of the first 6 days of menses (M1–M6) and the first 8 days following ovulation (L1–L8) over two cycles. The largest mean differences were observed between L5 and L8 for AKL (0.32 mm), and between L5 and M1 for GR (0.56°) and GJL (0.26) (p < 0.013). At the individual level, mean absolute cyclic changes in AKL (1.8 ± 0.7 mm, 1.6 ± 0.7 mm), GR (2.8 ± 1.0°, 2.4 ± 1.0°), and GJL (1.1 ± 1.1, 0.7 ± 1.0) were more apparent, with minimum, maximum and delta values being quite consistent from month to month (ICC2,3 = 0.51–0.98). Although the average daily pattern of change in laxity was quite similar between variables (Spearman correlation range 0.61 and 0.90), correlations between laxity measures at the individual level were much lower (range −0.07 to 0.43). Substantial, similar, and reproducible cyclic changes in AKL, GR, and GJL were observed across the menstrual cycle, with the magnitude and pattern of cyclic changes varying considerably among females.

The Relationship Between Lower Extremity Alignment Characteristics and Anterior Knee Joint Laxity

Background: Lower extremity alignment may influence the load distribution at the knee, potentially predisposing the anterior cruciate ligament to greater stress. We examined whether lower extremity alignment predicted the magnitude of anterior knee laxity in men and women. Hypothesis: Greater anterior pelvic angle, hip anteversion, tibiofemoral angle, genu recurvatum, and navicular drop will predict greater anterior knee laxity. Study Design: Descriptive laboratory study. Methods: Women (n = 122) and men (n = 97) were measured for anterior knee laxity and 7 lower extremity alignment variables on their dominant stance leg. Linear regression determined the extent to which the alignment variables predicted anterior knee laxity for each sex. Results: Lower anterior pelvic tilt and tibiofemoral angle, and greater genu recurvatum and navicular drop were related to greater anterior knee laxity in women, explaining 28.1% of the variance (P < .001). Lower anterior pelvic tilt and greater hip anteversion, genu recurvatum and navicular drop were predictors of greater anterior knee laxity in men, explaining 26.5% of the variance (P < .001). Conclusion: Lower anterior pelvic tilt, greater knee hyperextension, and foot pronation predicted greater anterior knee laxity in both men and women, with genu recurvatum and navicular drop having the greatest impact on anterior knee laxity. Greater hip anteversion was also a strong predictor in men, while a lower tibiofemoral angle was a significant predictor in women. Clinical Relevance: The associations between lower extremity alignment and anterior knee laxity suggest that alignment of the hip, knee, and ankle may be linked to or contribute to abnormal loading patterns at the knee, potentially stressing the capsuloligamentous structures and promoting greater joint laxity.