Anil Kumar RamRakhyani

On the Design of Efficient Multi-Coil Telemetry System for Biomedical Implants

Two-coil based inductive coupling is a commonly used technique for wireless power and data transfer for biomedical implants. Because the source and load resistances are finite, two-coil systems generally achieve a relatively low power transfer efficiency. A novel multi-coil technique (using more than two coils) for wireless power and data transfer is considered to help overcoming this limitation. The proposed multi-coil system is formulated using both network theory and a two-port model. Using three or four coils for the wireless link allows for the source and load resistances to be decoupled from the Q-factor of the coils, resulting in a higher Q -factor and a corresponding improved power transfer efficiency (PTE). Moreover, due to the strong coupling between the driver and the transmitter coil (and/or between the receiver and the load coil), the multi-coil system achieves higher tunable frequency bandwidth as compared to its same sized two-coil equivalent. Because of the wider range of reflected impedance in the multi-coil system case, it is easier to tune the output power to the load and achieve the maximum power transfer condition for given source voltage than in a configuration with two coils. Experimental results showing a three-coil system achieving twice the efficiency and higher gain-bandwidth product compared to its two-coil counterpart are presented. In addition, a figure of merit for telemetry systems is defined to quantify the overall telemetry system performance.

Improving Power Transfer Efficiency of a Short-Range Telemetry System Using Compact Metamaterials

Wireless power transfer using resonant inductive coupling has been employed in a number of applications, including wireless charging of electronic devices and powering of implanted biomedical devices. In these applications, power is transferred over short distances, which are much smaller (~ λ/100) than the wavelength of operation. In such systems, the power transfer efficiency of the link is inversely related to the range of operation. The power transfer efficiency is principally a function of the Qs of the individual coils and the coupling between them. In this paper, we demonstrate improvements in power transfer efficiencies using negative permeability metamaterials by increasing the mutual coupling between coils. A metamaterial slab is designed for operation at 27 MHz and is compact in size. The power transfer efficiency of the telemetry system in free space is compared to that in the presence of the metamaterial placed near one of the coils. The efficiency of the system increased in the presence of the metamaterial even as the free-space separation was held constant. This shows that compact negative permeability metamaterials can be used to increase power transfer efficiency of short-range telemetry systems used in various applications.

On the Design of Microfluidic Implant Coil for Flexible Telemetry System

This paper describes the realization of a soft, flexible, coil fabricated by means of a liquid metal alloy encased in a biocompatible elastomeric substrate for operation in a telemetry system, primarily for application to biomedical implantable devices. Fluidic conductors are in fact well suited for applications that require significant flexibility as well as conformable and stretchable devices, such as implantable coils for wireless telemetry. A coil with high conductivity, and therefore low losses and high unloaded Q factor, is required to realize an efficient wireless telemetry system. Unfortunately, the conductivity of the liquid metal alloy considered-eutectic gallium indium (EGaIn)-is approximately one order of magnitude lower than gold or copper. The goal of this paper is to demonstrate that despite the lower conductivity of liquid metal alloys, such as EGaIn, compared with materials, such as copper or gold, it is still possible to realize an efficient biomedical telemetry system employing liquid metal coils on the implant side. A wireless telemetry system for an artificial retina to restore partial vision to the blind is used as a testbed for the proposed liquid metal coils. Simulated and measured results show that power transfer efficiency of 43% and 21% are obtained at operating distances between coils of 5 and 12 mm, respectively. Further, liquid metal based coil retains more than 72% of its performance (voltage gain, resonance bandwidth, and power transfer efficiency) when physically deformed over a curved surface, such as the surface of the human eye. This paper demonstrates that liquid metal-based coils for biomedical implant provide an alternative to stiff and uncomfortable traditional coils used in biomedical implants.

Multicoil Telemetry System for Compensation of Coil Misalignment Effects in Implantable Systems

Inductive coupling-based wireless power transfer (WPT) is commonly used for near-field power and data transfer to implanted electronics. Some implanted coils undergo relative motion during device operation causing variation in magnetic coupling from their normal position. To ensure stable power transfer efficiency and frequency bandwidth, these WPT systems should have high tolerance with coupling variation. In this letter, a multicoil-based WPT system is utilized to achieve high tolerance for system power transfer efficiency and data bandwidth. It is demonstrated that a multicoil WPT system can reduce variation by half in power transfer efficiency (PTE) and by one third in frequency bandwidth compared to a two-coil WPT system with the same dimensions and operating conditions.

Compact Low-Frequency Metamaterial Design for Wireless Power Transfer Efficiency Enhancement

An extremely compact and low-frequency metamaterial design is presented in the following work. A ferrite loaded solenoid with a size on the order of 1/10000 of the wavelength of operation is used as the unit cell of the proposed metamaterial. This unit cell allows for the construction of a 77 unit-cell sample with dimensions of 6 cm × 6 cm × 2 cm and operating at a working frequency of 5.57 MHz. Measurements show that using this metamaterial sample in a wireless power transfer (WPT) system results in an efficiency enhancement of 10% at a working distance of 4.5 cm, which is twice the efficiency of the original system at the same distance. Alternatively, for a target efficiency of 10%, the range of the system can be extended from 4.5 to 8.8 cm by using the proposed metamaterial, a 4.3-cm, or 95%, extension over the original system range. The proposed metamaterial design, characterized by compactness, low frequency of operation, and large efficiency enhancement, is useful in a number of applications, such as biomedical telemetry systems and wireless charging.

A

There has been recurring interest in using magnetic neural stimulation for implantable localized stimulation. However, the large stimulation voltages and energies necessary to evoke neuronal activity have tempered this interest. To investigate the potential of magnetic stimulation as a viable methodology and to provide the ability to investigate novel coil designs that can result in lower stimulation threshold voltages and energies, there is a need for a model that accurately predicts the magnetic field-tissue interaction that results in neuronal stimulation. In this study, we provide a computational framework to accurately estimate the stimulation threshold and have validated the model with in vivo magnetic stimulation experiments. To make such predictions, we developed a micrometer-resolution anatomically driven computational model of rat sciatic nerve and quantified the effect of tissue heterogeneity (i.e., fascicular organization, axon distribution, and density) and axonal membrane capacitance on the resulting threshold. Using the multiresolution impedance method, we computed the spatial-temporal distribution of the induced electric field in the nerve and applied this field to a Frankenhaeuser-Huxley axon model in NEURON to simulate the nonlinear mechanisms of the membrane channels. The computational model developed predicts the stimulation thresholds for four magnetic coil designs with different geometrical parameters within the 95% confidence interval (experiments count = 4) of measured in vivo stimulation thresholds for the rat sciatic nerve.

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Functional electrical stimulation is the current gold standard for stimulating neuronal interfaces for functional neuromuscular and cortical applications, but it is not without its drawbacks. One such fault is the need to have direct electrical contact with the nerve tissue, and any side effects this causes. Functional magnetic stimulation, which works though electromagnetic induction, does not require electrical contact and may be a viable alternative to functional electrical stimulation. We are investigating the capabilities of magnetic stimulation with centimeter scale (<; 2.5 cm) coils in feline and rodent sciatic nerves in vivo. We have shown that magnetic stimulation can consistently produce the same levels of neuromuscular activation as electrical stimulation. Additionally, the position of the coil relative to the nerve influences neuromuscular activation, suggesting the possibility of selective muscle activation.

m-Scale Computational Model of Magnetic Neural Stimulation in Multifascicular Peripheral Nerves

Previous reports of magnetic stimulation of the peripheral nervous system (PNS) used various coil geometries, all with outer diameters larger than 35 mm, and stimulation energies in the 50 J range to evoke neural excitation. Recent reports of central nervous system (CNS) activation used sub-mm-scale solenoid coils with mJ energy levels. The goal of this study was to translate the lower energy levels from the CNS to the PNS via using smaller coils placed in closer proximity to the neural tissue. Such a performance improvement would advance the state of the art of magnetic stimulation and provide a path towards new neuroprosthetic devices. Primarily, we investigated the range of coil outer diameters from 25 mm down to 5 mm to better understand the dependence of coil diameter on energy required for PNS activation. Nine cm- and mm-scale copper solenoid coils, with various resistances, inductances, inner and outer diameters, and heights were compared by quantizing neuromuscular responses to magnetic stimulation via capacitive discharge excitation of rat sciatic nerves in vivo. Additionally, the effects of stimulus duration and coil position were investigated. As opposed to prior work, this study compares a subset of stimulation parameters in an intact nerve preparation, and shows that magnetic stimulation with coils that abut the nerve is a reliable, effective method of neuromuscular stimulation. Although we observed different energies required for neuromuscular activation depending on the coil and excitation parameters used, for the experimental configuration, devices, and stimulus waveform shapes presented in this manuscript, no systematic dependence of PNS activation on coil diameter was found, even for the mm-scale coils investigated herein. However, there was a clear relationship between discharge circuit capacitance and energy required to evoke a neuromuscular response. Coils approximately 12 mm in outer diameter and larger consistently evoked responses, whereas coils 5 mm in outer diameter did not. Furthermore, we observed meaningful neuromuscular excitation when stimulating with energies as low as 20 J. Although this is an improvement over prior work, it is still orders of magnitude greater than the energy required for conventional electrical stimulation, suggesting that these devices are presently not suitable for use in an application requiring continued pulsed stimulation. Nevertheless, these devices are suitable for basic research and as clinical tools that infrequently stimulate, such as in diagnostic applications.

Magnetic stimulation of mammalian peripheral nerves in vivo: an alternative to functional electrical stimulation.

A popular technique for wireless power transfer, particularly in biomedical implants, is inductive coupling. One of the first applications of this technique in the biomedical field was to supply power to an artificial heart. Since then, it has commonly been used in implantable devices. For short-range wireless power transfer systems, working on inductive coupling, power transfer efficiency, voltage gain and data bandwidth are generally key performance parameters that need to be optimized to design an efficient system. These parameters are strong functions of the quality factor (Q) of the magnetic coils and the coupling between the external and implant coils. Traditionally, two coils are employed in power/data transfer systems: however, due to the moderate Q-factor of the coils and low coupling between the coils, these inductive coupled power/data transfer systems have generally limited power transfer efficiency (<; 40 %) and limited data bandwidth (<; 10% of carrier frequency). Performance variation during the operation of the device is one of the main challenges for a two-coil based system. Two-coil based Wireless Power Transfer (WPT) systems suffer from instable link performance due to variation caused by the change in operating distance, coil misalignment, device operation mode, and change in driver resistance.

In Vivo Magnetic Stimulation of Rat Sciatic Nerve With Centimeter- and Millimeter-Scale Solenoid Coils

Near-field inductive coupling is a commonly used technique for wireless power transfer (WPT) in biomedical implants. Owing to the close proximity of the implant coil(s) with the tissue ( ∼1 mm) and high current ( ∼100-300 mA) in the magnetic coil(s), a significant induced electric field can be generated for the operating frequency (1-20 MHz). In this Letter, a multi-coil-based WPT technique is proposed to selectively control the currents in the external and implant coils to reduce the specific absorption rate (SAR). A three-coil WPT system, that can achieve 26% reduction in peak 1-g SAR and 15% reduction in peak 10-g SAR, as compared to a two-coil WPT system with the same dimensions, is implemented and used to demonstrate the effectiveness of the proposed approach. To achieve the seamless design for the external and implant electronics, the multi-coil system achieves the same voltage gain and bandwidth as the two-coil design with 46% improvement in the power transfer efficiency.