Anil Kumar Verma
University of Lucknow
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Publication
Featured researches published by Anil Kumar Verma.
Drug Research | 2017
Anil Kumar Verma; Abha Bishnoi; Shaheen Fatma; Huda Parveen; Vineeta Singh
A simple and highly efficient procedure for the synthesis of novel thiazol-2-amines, via Mannich reaction with secondary amines, is described. The newly synthesized derivatives 8(A-E): and 9(A-E): were characterized by 1H NMR, 13C NMR, IR, Mass spectroscopy and elemental analysis. All the derivatives were evaluated for their in-vitro anti-microbial activity against a panel of pathogenic strains of bacteria and fungi. The SAR showed that the secondary amines had a significant impact on the in-vitro antimicrobial activity of this class of agents. The most potent analogue N-((1H-benzo[d]imidazol-1-yl)methyl)-N-(2(trifluoromethyl)phenyl)-4,5-dihydrothiazol-2-amine (8C): showed excellent inhibition with MIC (zoi) 6.25 (22.5), 25 (21.5) and 25 (18) µg/mL against E. coli, S. typhi and P. aeruginosa respectively as compared to the standard drug. Molecular docking results suggest that compound exhibited inhibitory activity by binding of the title compound within the active sites of the inhibiting Enoyl ACP reductase, Lipid A, Pyridoxal kinase and type I DHQase enzymes. The compound exhibited promising anti-microbial activity which can be further explored as potential lead for the development of cheaper, safe, effective and potent drugs against resistant microbial parasites.
Heterocyclic Communications | 2015
Anil Kumar Tiwari; Abha Bishnoi; Anil Kumar Verma; Shaheen Fatma; Krishna Srivastava; C. K. M. Tripathi; Bikram Banerjee
Abstract Novel spiro derivatives of piperidone 4a–f were synthesized, characterized, and screened against a panel of different bacterial and fungal strains. The study revealed the potential of these molecules for further development as antimicrobial agents.
Journal of Molecular Structure | 2015
Shaheen Fatma; Abha Bishnoi; Anil Kumar Verma
Journal of Molecular Structure | 2016
Anil Kumar Verma; Abha Bishnoi; Shaheen Fatma
Journal of Molecular Structure | 2018
Shaheen Fatma; Abha Bishnoi; Anil Kumar Verma; Vineeta Singh; Krishna Srivastava
ChemistrySelect | 2018
Shraddha Shukla; Abha Bishnoi; Shaheen Fatma; Anil Kumar Verma; Poornima Devi
Journal of Molecular Structure | 2017
Shaheen Fatma; Abha Bishnoi; Anil Kumar Verma; Ramesh P. Singh; Amrita Srivastava
ChemistrySelect | 2017
Anil Kumar Verma; Abha Bishnoi; Shaheen Fatma; Huda Parveen; Vineeta Singh
Der Pharma Chemica | 2016
Anil Kumar Verma; Abha Bishnoi; Shaheen Fatma; Amrita Srivastava; Vineeta Singh
Indo American Journal of Pharmaceutical Research | 2015
Shaheen Fatma; Abha Bishnoi; Anil Kumar Verma; Amrita Srivastava; Vineeta Singh; C. K. M. Tripathi