Anil M. Sanghani

Synthesis and biological screening of 1,2,4-triazole derivatives

A series of 2-((arylamino)methyl)-5-(3-methoxyphenyl)-1-phenyl-1H-1,2,4-triazole-3-thione derivatives have been synthesized and characterized by FT-IR, NMR, mass spectral and elemental analysis. Compounds (MM4a-m) have been evaluated for their in vitro antibacterial activity against selected gram-positive and gram-negative bacteria and in vitro antifungal activity against fungal pathogens by using broth dilution method. The compounds have been screened for antitubercular activity against Mycobacterium tuberculosis H37Rv strain by using L J Slope method. Of all the compounds, MM4d, MM4e, MM4j and MM4k show good antibacterial activity and MM4a, MM4d, MM4e and MM4j compounds have been found to possess good antitubercular activity.

An efficient synthesis, characterization, and antimicrobial screening of tetrahydropyrimidine derivatives

Several new substituted 1,2,3,4-tetrahydropyrimidine derivatives 2a–h have been synthesized by the modified Biginelli and Hantzsch reactions and compounds were characterized by spectral techniques. All compounds were evaluated for their in vitro antimicrobial activity against different strains of Gram-negative (E. coli and P. aeruginosa) and Gram-positive (S. aureus and S. pyogenus) bacteria and selected fungi C. albicans, A. niger, and A. clavatus using serial Broth dilution method (Mueller–Hinton broth dilution method). Compound 2e was found active against both Gram-negative and -positive bacterial strains used for present study, while compound 2b was good active against Gram-negative and S. pyogenus bacterial strains. Compounds 2a–h were not that much significant against (C. albicans, A. niger, and A. clavatus) selected fungal strains.