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Featured researches published by Animesh K. Ghose.


Journal of Inorganic Biochemistry | 1989

The effect of histidine on the structure and antitumor activity of metal-5-halouracil complexes

Udai P. Singh; Ranjana Ghose; Animesh K. Ghose; Ajit Sodhi; Sukh Mahendra Singh; Rakesh K. Singh

The ternary complexes of Mn(II), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) ions with 5-halouracils, viz., 5-fluorouracil (5FU), 5-chlorouracil (5ClU), and 5-bromouracil (5BrU), and the biologically important ligand L-histidine (HISD) have been synthesized and characterized by elemental analysis, conductance measurements, infrared spectra, electronic spectra, and magnetic moment (room temperature) measurements. On the basis of these studies, the structures of the complexes have been proposed. All these ternary complexes were screened for their antitumor activity against Daltons lymphoma in C3H/He mice. It was found that only Mn(II)-5BrU-HISD, Co(II)-5BrU-HISD, Cu(II)-5ClU-HISD, Cu(II)-5BrU-HISD, Zn(II)-5FU-HISD, and Zn(II)-5BrU-HISD complexes have significant antitumor activity with T/C greater than 125% (where T and C represent mean lifespan of treated mice and control mice respectively). The Mn(II)-5FU-HISD, Co(II)-5FU-HISD, Co(II)-5ClU-HISD, Ni(II)-5ClU-HISD, Ni(II)-5BrU-HISD, and Zn(II)-5ClU-HISD complexes are also effective antitumor agents, with T/C greater than 115%. The complexes that showed effective antitumor action in vivo were also found to inhibit 3H-thymidine incorporation (DNA replication) in Daltons lymphoma cells in vitro.


Journal of Inorganic Biochemistry | 1991

Synthesis, characterization, and antitumor activity of 5-iodouracil complexes

Udai P. Singh; Badri N. Singh; Animesh K. Ghose; Rakesh K. Singh; Ajit Sodhi

Complexes of 5-iodouracil (5IU) with Mn(II), Co(II), Cu(II), Zn(II), and Cd(II) ions have been prepared, characterized, and subjected to a screening system for evaluation of antitumor activity against Sarcoma-180 (S-180) and L 929 tumor cells. The complexes were characterized by their elemental analysis, infrared spectra, electronic spectra, magnetic measurements, and powder x-ray diffraction. The antitumor activity results indicate that some complexes have good antitumor activity both in vivo and in vitro against S-180 and L 929 tumor cells.


Transition Metal Chemistry | 1988

Transition metal complexes of 5-chlorouracil

Udai P. Singh; Ranjana Ghose; Animesh K. Ghose

SummaryComplexes of 5-chlorouracil (5-ClU) (1) with 3d metal ions were characterized by elemental analysis, various spectroscopic methods (i.r., u.v. spectroscopy) and magnetic susceptibility measurements. The spectral evidence suggest that 5-ClU behaves as bidentate ligand in NiII, CuII, ZnII, and CdII compounds, coordinating through its one carbonyl oxygen and one nitrogen whereas with MnII and CoII it coordinates through the carbonyl oxygen only. The insolubility of the new complexes in organic solvents suggests that these are polymeric except for the CoII complex which is soluble in pyridine. There is probable OH bridging in the MnII and CuII complexes and the 5-ClU may bridge in the rest.


Inorganica Chimica Acta | 1987

Complexes of some trace metal ions with 5-fluorouracil

Udai P. Singh; Ranjana Ghose; Animesh K. Ghose

Abstract The preparation of 5-fluorouracil complexes with Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) are reported. The new complexes have been characterised by elemental analysis, solid-state infrared, electronic spectra and magnetic measurements. These measurements suggest that the ligand is bonded to the metal ions through the carbonyl group, behaving as a mono- dentate ligand. On the basis of the ν(OH)bending frequencies and the insolubility of the complexes in common organic solvents, polymeric structures have been proposed for the complexes, with bridging through OH groups. Mn(II), Zn(II) and Cd(II) form four-coordinated complexes, while six coordination numbers have been suggested for Co(II), Ni(II) and Cu(II).


Transition Metal Chemistry | 1988

Simple and mixed complexes of cobalt(II) and cobalt(III) ions

Mandalika S. Sastry; Ranjana Ghose; Animesh K. Ghose

SummaryBivalent and trivalent cobalt complexes with 1-(2-pyridylazo)-2-naphthol (PAN), PAN+1, 10-phenanthroline and PAN+2, 2′-bipyridyl were prepared and characterized by physico-chemical and magnetic measurements. The spectral studies suggest that PAN behaves as a bidentate ligand and is coordinated to metal ions through oxygen and (pyridine) nitrogen, whereas 1, 10-phenanthroline and 2, 2′-bipyridyl are coordinated through (pyridine) nitrogen. The tentative ν(M−O) and ν(M−N) band assignments in the lower i.r. region, and magnetic moment data favour four coordination for the complexes studied.


Synthesis and Reactivity in Inorganic and Metal-organic Chemistry | 1994

Synthesis and Spectroscopic Studies of Simple and Mixed Complexes of Nickel(II) and Zinc(II) with an AZO Dye

Mandalika S. Sastry a; Udai P. Singh; Animesh K. Ghose

Abstract New simple and mixed complexes of 1-(2-pyridylazo)-2-naphthol (PAN) and 1,10-phenanthroline (phen) or 2,2′-bipyridyl (bipy) with nickel(II) and zinc(II) were synthesized and characterized by elemental analyses, conductivity, infrared, electronic spectra, room temperature magnetic measurements, and X-ray diffraction studies. The I. R. data suggest the coordination of PAN through oxygen and (pyridine) nitrogen, whereas phen and bipy coordinate through the pyridine nitrogens. The UV-Vis. spectra along with magnetic measurements favor a tetrahedral geometry for the complexes. The podwer X-ray diffraction studies indicate tetragonal symmetry for all these complexes except for Ni(II)-PAN-phen, which has orthorhombic symmetry. aPresent address: School of Materials Science and Technology, I. T, B.H.U., Varanasi - 221 005, India Referee I: C. E. Barnes Referee II: T. C. Strekas


Synthesis and Reactivity in Inorganic Metal-organic and Nano-metal Chemistry | 1991

Oxovanadium(IV) and Dioxouranium(VI) Complexes of Azo Dyes

Mandalika S. Sastry; Udai P. Singh; Ranjana Ghose; Animesh K. Ghose

Abstract Oxovanadium(IV) and dioxouranium(VI) complexes of 1-(2-pyridylazo)-2-naphthol (PAN) and 4-(2-pyridylazo) resorcinol (PAR) have been prepared and characterised by elemental analyses, various physico-chemical methods and magnetic measurements. The I. R. observations suggest that PAN is coordinated through oxygen and (pyridine) nitrogen, whereas PAR is coordinated through (pyridine) nitrogen and the ortho-hydroxyl group. The spectral-studies suggest that oxovanadium(IV) complexes have the coordination number five and dioxouranium(Vl) complexes have the coordination number six for the cations.


Bulletin of the Chemical Society of Japan | 1990

Characterization of metal chelation with a mutagenic agent, 5-bromouracil.

Udai P. Singh; Ranjana Ghose; Animesh K. Ghose


Crystal Research and Technology | 1989

X-ray diffraction studies on 5-chlorouracil complexes with cobalt(II) and nickel (II)

Udai P. Singh; Ranjana Ghose; Animesh K. Ghose


Crystal Research and Technology | 1995

X‐ray diffraction studies on metal complexes of 5‐nitrouracil

Udai P. Singh; Badri N. Singh; Mandalika S. Sastry; Animesh K. Ghose

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Udai P. Singh

Banaras Hindu University

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Ranjana Ghose

Banaras Hindu University

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Ajit Sodhi

Banaras Hindu University

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Badri N. Singh

Banaras Hindu University

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