Anjali Jha

Structure property studies revealed a new indoylfuranone based bifunctional chemosensor for Cu2+ and Al3+

The present report highlights the role of comprehensive structure property relationships (SPRs) in the discovery of a new and more effective molecular system for sensing purposes. From an extensive survey of different classes of amino substituted annulated furanones, it was realized that with some exceptions, these functionalized furanones could sense Cu2+ ions in the semi-aqueous phase irrespective of the nature of substituents; furthermore the same scaffolds could also detect Al3+, if the aldehydic position is specifically filled by a 3-indoyl group. As a result, amino substituted annulated furanones with 3-indoyl groups could detect both metal ions, response time of which mainly depends on the overall molecular framework. After replacing different furanone frameworks, a dual metal ion sensor (for Cu2+ and Al3+) with short response time and high selectivity and association constant was identified. The proposed bifunctional sensor displayed a distinct but observable response (turn off colorimetric for Cu2+ and turn on fluorescence for Al3+) to both metal ions with potential applications in the area of real sample analysis and membrane sensing.

Expeditious microwave-assisted synthesis and bio-evaluation of novel bis (trifluoromethyl) phenyl-triazole-pyridine hybrid analogues by the click chemistry approach

AbstractA series of novel 1,2,3-triazole-2,4-bis(trifluoromethyl) phenyl pyridine hybrids 7a–n were efficiently synthesized by the click chemistry approach. The precursor 6-(3,5-bis(trifluoromethyl)phenyl)pyridin-3-ol 3 was obtained by palladium catalyzed cross coupling between 6-bromo-3-pyridinol (2) and (3,5-bis (trifluoromethyl) phenyl) boronic acid (1) in a microwave under nitrogen conditions, which was further alkylated with propargyl bromide 4 in DMF in the presence of K2CO3 and a catalytic amount of TBAI to get 5. All products obtained in each step were well characterized by various spectral studies and found consistent with expected structure. The triazole derivatives 7a–n were evaluated against human bacterial pathogens, namely, Escherichia coli, Salmonella typhimurium and Staphylococcus aureus and fungal strains Aspergillus niger, Fusarium solani and Penicillium notatum for in vitro activity. Among them, 7e and 7m emerged as potential compounds comparable with the standard drug Ciprofloxacin against tested bacteria, and it is worthwhile to notice that compound 7k emerged more potent than the standard Griseofulvin against fungi.

Optical and electrochemical dual channel sensing of Cu 2+ using functionalized furo[2,3- d ]pyrimidines-2,4[1 H ,3 H ]-diones

Owing to their easy accessibility and high degree of structural and functional diversity, many multicomponent reactions (MCRs) have been a rich source of conjugate π-systems, functionalised chromophores (or fluorophore) and redox active molecules. Despite their high explorative potential and practical benefits, only a few MCR products have been so far investigated for their metal sensing abilities. In the present report, two furopyrimidinones (FPys) based molecular systems have been synthesized by [4+1] cycloaddition based MCR sequence. Designed chemosensors displayed optic (absorption spectra) as well as electroanalytical (ion selective electrode) response toward Cu2+ ion in solution and membrane phase respectively (dual channel sensing). Different aspects of both the sensing phenomena such as selectivity, association constants, detection limit, membrane composition etc. were studied in detail using UV-Vis spectroscopy, NMR titration and cell assembly. Both the compounds showed excellent performance characteristics such as high selectivity, acceptable affinity and low detection limits (10-7M) in both sensing assays with potential utility in the area of sample monitoring.

Synthesis, docking and anticancer activity of azo-linked hybrids of 1,3,4-thia-/oxadiazoles with cyclic imides

A series of novel analogues based on a diazole-imide pharmacophore were synthesized by diazotizing substituted 1,3,4-thia-/oxadiazol-2-amines and subsequently coupling the resulting diazonium salts with N-substituted cyclic imides. The resulting compounds C1 to C28 were characterized by various spectral methods, viz. IR, NMR and mass spectroscopy. All the synthesized compounds were tested against two human cancer cell lines: human breast adenocarcinoma cell line MCF-7 and colorectal adenocarcinoma cell line HT-29. Among the synthesized compounds, C14 (2-(4-chloro-3-((5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl)diazenyl)phenyl)-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione) emerged as a potential candidate against both MCF-7 and HT-29 with

Induced crystal G phase of liquid crystalline amide through inter molecular hydrogen bonding

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Quantum chemical studies of cinnamic acid with anilines for electroptical activity

IC50 values of 0.09 ± 0.02

Synthesis and quantum chemical studies of metalloorganics for electro-optical studies

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