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Dive into the research topics where Ankur Omer is active.

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Featured researches published by Ankur Omer.


The Scientific World Journal | 2014

Erratum to “Next Generation Sequencing: Potential and Application in Drug Discovery”

Navneet Kumar Yadav; Pooja Shukla; Ankur Omer; Shruti Pareek; A. K. Srivastava; F.W. Bansode; R. K. Singh

Through this erratum the authors declare that two coauthors were missing in the article entitled “Next generation sequencing: potential and application in drug discovery”. The correct list of the authors and their affiliations are as shown above.


The Scientific World Journal | 2014

Next Generation Sequencing: Potential and Application in Drug Discovery

Navneet Kumar Yadav; Pooja Shukla; Ankur Omer; Shruti Pareek; R. K. Singh

The world has now entered into a new era of genomics because of the continued advancements in the next generation high throughput sequencing technologies, which includes sequencing by synthesis-fluorescent in situ sequencing (FISSEQ), pyrosequencing, sequencing by ligation using polony amplification, supported oligonucleotide detection (SOLiD), sequencing by hybridization along with sequencing by ligation, and nanopore technology. Great impacts of these methods can be seen for solving the genome related problems of plant and animal kingdom that will open the door of a new era of genomics. This may ultimately overcome the Sanger sequencing that ruled for 30 years. NGS is expected to advance and make the drug discovery process more rapid.


Oxidative Medicine and Cellular Longevity | 2015

Saraca indica Bark Extract Shows In Vitro Antioxidant, Antibreast Cancer Activity and Does Not Exhibit Toxicological Effects

Navneet Kumar Yadav; Karan Singh Saini; Zakir Hossain; Ankur Omer; Chetan Sharma; Jiaur R. Gayen; Poonam Singh; Kamal Ram Arya; R. K. Singh

Medicinal plants are used as a complementary and alternative medicine in treatment of various diseases including cancer worldwide, because of their ease of accessibility and cost effectiveness. Multicomposed mixture of compounds present in a plant extract has synergistic activity, increases the therapeutic potential many folds, compensates toxicity, and increases bioavailability. Saraca indica (family Caesalpiniaceae) is one of the most ancient sacred plants with medicinal properties, exhibiting a number of pharmacological effects. Antioxidant, antibreast cancer activity and toxicological evaluation of Saraca indica bark extract (SIE) were carried out in the present study. The results of the study indicated that this herbal preparation has antioxidant and antibreast cancer activity. Toxicological studies suggest that SIE is safer to use and may have a potential to be used as complementary and alternative medicine for breast cancer therapy.


Mini-reviews in Medicinal Chemistry | 2014

An overview of data mining algorithms in drug induced toxicity prediction.

Ankur Omer; Poonam Singh; Navneet Kumar Yadav; R. K. Singh

The growth in chemical diversity has increased the need to adjudicate the toxicity of different chemical compounds raising the burden on the demand of animal testing. The toxicity evaluation requires time consuming and expensive undertaking, leading to the deprivation of the methods employed for screening chemicals pointing towards the need to develop more efficient toxicity assessment systems. Computational approaches have reduced the time as well as the cost for evaluating the toxicity and kinetic behavior of any chemical. The accessibility of a large amount of data and the intense need of turning this data into useful information have attracted the attention towards data mining. Machine Learning, one of the powerful data mining techniques has evolved as the most effective and potent tool for exploring new insights on combinatorial relationships among various experimental data generated. The article accounts on some sophisticated machine learning algorithms like Artificial Neural Networks (ANN), Support Vector Machine (SVM), k-mean clustering and Self Organizing Maps (SOM) with some of the available tools used for classification, sorting and toxicological evaluation of data, clarifying, how data mining and machine learning interact cooperatively to facilitate knowledge discovery. Addressing the association of some commonly used expert systems, we briefly outline some real world applications to consider the crucial role of data set partitioning.


Expert Review of Anticancer Therapy | 2013

Hematological malignancies: role of miRNAs and their in silico aspects

Ankur Omer; Navneet Kumar Yadav; Poonam Singh; Rama Kant Singh

Hematological malignancies is a broad term that includes blood cell cancers including chronic lymphocytic leukemia (CLL), chronic myeloid leukemia (CML), acute myeloid leukemia (AML), Myelodysplastic syndrome, acute lymphocytic leukemia (ALL), multiple myelomas (MM) and lymphomas. miRNAs are ~22-nt long non-coding RNAs that play a very important role in gene regulation by binding to mRNA at their complementary sequence. These miRNAs are conceptually connected with various signal and pathway networks that make them capable of regulating various diseases including hematological malignancies. These miRNAs are not only playing regulatory roles in hematological malignancies, but are also providing new potent markers for efficient diagnosis and prognosis for hematological malignancies patients. Since the discovery of very first miRNA, the importance and role of miRNAs have been established in various fields, and there is a need to search for new potent miRNAs and their targets. A large amount of sequence data have been generated in last few years, which has further generated the need to develop efficient and reliable computational tools to analyze and extract out relevant information promptly from raw data. Here, we review various possible roles played by miRNA in hematological malignancies, principles involved in miRNA gene identification, target prediction and their preceding role in hematological malignancies research.


Drug and Chemical Toxicology | 2016

Alternative methods in toxicology: CFU assays application, limitation and future prospective

Navneet Kumar Yadav; Pooja Shukla; Ankur Omer; Poonam Singh; Rajneesh Kumar Singh

Abstract Blood is a fluid connective tissue which plays a vital role for normal body function. It consist different type of blood cells which is continuously reproduce inside the bone marrow from hematopoietic system. Xenobiotics could be specifically toxic to the hematopoietic system and they can cause hematological disorders by disturbing the normal functions. In vitro hematopoietic colony-forming cell assays play a crucial role to evaluate potential toxic effects of new xenobiotics and also helpful in bridging the gap between preclinical toxicology studies in animal models and clinical investigations. Use of these assays in conjunction with, high-throughput screening reduces the cost and time associated with these assays. This article provides a critical view over in vitro hematopoietic colony-forming cell assays in assessment of hematotoxicity.


Wiley Interdisciplinary Reviews - Rna | 2015

microRNAs: role in leukemia and their computational perspective

Ankur Omer; Poonam Singh; Navneet Kumar Yadav; Rama Kant Singh

MicroRNAs (miRNAs) belong to the family of noncoding RNAs (ncRNAs) and had gained importance due to its role in complex biochemical pathways. Changes in the expression of protein coding genes are the major cause of leukemia. Role of miRNAs as tumor suppressors has provided a new insight in the field of leukemia research. Particularly, the miRNAs mediated gene regulation involves the modulation of multiple mRNAs and cooperative action of different miRNAs to regulate a particular gene expression. This highly complex array of regulatory pathway network indicates the great possibility in analyzing and identifying novel findings. Owing to the conventional, slow experimental identification process of miRNAs and their targets, the last decade has witnessed the development of a large amount of computational approaches to deal with the complex interrelations present within biological systems. This article describes the various roles played by miRNAs in regulating leukemia and the role of computational approaches in exploring new possibilities. WIREs RNA 2015, 6:65–78. doi: 10.1002/wrna.1256


Advances in Protein Chemistry | 2015

Explicit Drug Re-positioning: Predicting Novel Drug–Target Interactions of the Shelved Molecules with QM/MM Based Approaches

Ankur Omer; Venkatesan Suryanarayanan; Chandrabose Selvaraj; Sanjeev Kumar Singh; Poonam Singh

With the demand to enhance the speed of the drug discovery process there has been an increased usage of computational approaches in drug discovery studies. However because of their probabilistic outcomes, the challenge is to exactly mimic the natural environment which can provide the exact charge polarization effect while estimating the binding energy between protein and ligand. There has been a large number of scoring functions from simple one to the complex one available for estimating binding energy. The quantum mechanics/molecular mechanics (QM/MM) hybrid approach has been the preferred choice of interest since last decade for modeling reactions in biomolecular systems. The application of QM/MM approach has been expanded right from rescoring the already known complexes and depicting the correct position of some novel molecule to ranking a large number of molecules. It is expected that the application of QM/MM-based scoring will grow in all areas of drug discovery. However, the most promising area will be its application in repositioning, that is, assigning novel functions or targets to the already existing drugs, as this would stop the rising attrition rates as well as reduce the overall time and cost of drug discovery procedure.


Journal of Biomolecular Structure & Dynamics | 2017

An integrated approach of network-based systems biology, molecular docking, and molecular dynamics approach to unravel the role of existing antiviral molecules against AIDS-associated cancer

Ankur Omer; Poonam Singh

A serious challenge in cancer treatment is to reposition the activity of various already known drug candidates against cancer. There is a need to rewrite and systematically analyze the detailed mechanistic aspect of cellular networks to gain insight into the novel role played by various molecules. Most Human Immunodeficiency Virus infection-associated cancers are caused by oncogenic viruses like Human Papilloma Viruses and Epstein–Bar Virus. As the onset of AIDS-associated cancers marks the severity of AIDS, there might be possible interconnections between the targets and mechanism of both the diseases. We have explored the possibility of certain antiviral compounds to act against major AIDS-associated cancers: Kaposi’s Sarcoma, Non-Hodgkin Lymphoma, and Cervical Cancer with the help of systems pharmacology approach that includes screening for targets and molecules through the construction of a series of drug–target and drug–target–diseases network. Two molecules (Calanolide A and Chaetochromin B) and the target “HRAS” were finally screened with the help of molecular docking and molecular dynamics simulation. The results provide novel antiviral molecules against HRAS target to treat AIDS defining cancers and an insight for understanding the pharmacological, therapeutic aspects of similar unexplored molecules against various cancers.


Journal of Biomolecular Structure & Dynamics | 2015

40 Exploring the possibilities for targeting the existing anti-viral molecules against cancer

Poonam Singh; Ankur Omer

References Bar-Even, A., Noor, E., Savir, Y., Liebermeister, W., Davidi, D., et al. (2011). The moderately efficient enzyme: Evolutionary and physicochemical trends shaping enzyme parameters. Biochemistry, 50, 4402–4410. Copeland, R. A., Pompliano, D. L., & Meek, T. D. (2007). Drug-target residence time and its implications for lead optimization (vol 5, pg 730, 2006). Nature Reviews Drug Discovery, 6, 249–249.

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Poonam Singh

Central Drug Research Institute

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Navneet Kumar Yadav

Central Drug Research Institute

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Pooja Shukla

Central Drug Research Institute

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R. K. Singh

Central Drug Research Institute

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Rama Kant Singh

Central Drug Research Institute

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A. K. Srivastava

National Physical Laboratory

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Chetan Sharma

Central Drug Research Institute

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F.W. Bansode

Central Drug Research Institute

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