Anna G. Wenzel

Olefin Cross-Metathesis

Olefin cross-metathesis has become an indispensable tool for efficient carbon–carbon bond formation. Fundamental studies on functional group tolerance and an understanding of the steric and electronic factors crucial to product selectivity have led to the development of an empirical model for reaction design. Due to the copious amount of recent literature pertaining to this reaction, this review focuses on reports pertaining to important aspects in either the concept or the application of alkene cross-metathesis. Strategies for effecting highly selective cross-metathesis reactions will be presented and discussed.

Efficient Microwave Method for the Oxidative Coupling of Phenols

GRAPHICAL ABSTRACT Abstract: The tert-butyl peroxide–initiated, oxidative coupling of phenols can frequently promote reactions that otherwise perform poorly under alternative conditions. Despite this utility, peroxide coupling reactions employing conventional heat often require high-dilution conditions, multiple additions of oxidant, and long reflux times, while regularly affording only moderate product yields. We recently developed an optimized protocol for peroxide-promoted, oxidative coupling that employs microwave heat. Product yields up to 98% have been attained. The performance and scope of this method relative to other oxidative coupling methodologies will be discussed.