Anne-Marie Bernard

Correlation Between Interictal Regional Cerebral Blood Flow and Depth-Recorded Interictal Spiking in Temporal Lobe Epilepsy

Summary: Purpose: Single photon emission computed tomography (SPECT) is used as an adjunctive method in preoperative localization of epileptic foci. In temporal lobe epilepsy (TLE), interictal hypoperfusion is observed in 60–70% of cases. Correlation with ictal EEG changes is observed in ∼50–60% of cases. Relationships with interictal EEG have been studied less. We compared interictal SPECT data obtained in 20 patients with their interictal intracerebral electrical activity recorded by depth electrodes to evaluate a potential relationship.

Ictal Single Photon Emission Computed Tomography in Occipital Lobe Seizures

Summary: Purpose: Ictal single photon emission computed tomography (SPECT) has been evaluated as an adjunctive localizing technique in temporal lobe epilepsies and, to a lesser degree, in some extratemporal epilepsies. The purpose of this study was to determine whether occipital lobe seizures are associated with distinctive ictal cerebral blood perfusion (rCP) patterns.

Validation of MRI/SPECT similarity-based registration methods using realistic simulations of normal and pathological SPECT data

We propose a validation methodology to study the behaviour of SPECT/MRI similarity-based registration methods in normal and pathological conditions. Validation data sets were computed by simulating realistic SPECT data from 3D Tl-weighted MRI data, through Monte Carlo simulations, using a perfusion model built from measurements made on real SPECT data (normal or pathological). Validation of four similarity-based registration methods performed on these simulated data showed a registration mean accuracy significantly lower than simulated SPECT spatial resolution.