Anne Uyttebroeck
Catholic University of Leuven
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Publication
Featured researches published by Anne Uyttebroeck.
Pediatric Blood & Cancer | 2005
Maarten Mennes; Peter Stiers; Erik Vandenbussche; Gertrui Vercruysse; Anne Uyttebroeck; Geert De Meyer; Stefaan Van Gool
Omitting radiotherapy for central nervous system (CNS) prophylaxis has improved the overall quality of life for long‐term survivors of childhood acute lymphoblastic leukemia (ALL). However, recent reports suggest minor cognitive impairment in survivors who received chemotherapy only.
The American Journal of Surgical Pathology | 2002
K. De Munnynck; S. Van Gool; Ph. Demaerel; Anne Uyttebroeck; Gunnar Buyse; Raphael Sciot
Desmoplastic infantile ganglioglioma is a rare intracranial tumor of early childhood with a usually excellent prognosis despite malignant features both radiologically and histologically. We present the case of a desmoplastic infantile ganglioglioma with histologically highly anaplastic features and both intracerebral and pial metastases. After partial resection the tumor was rapidly progressive and new metastases appeared. A combination of vincristine and carboplatinum was used according to the Low Grade Glioma Protocol of the International Society of Pediatric Oncology, with a temporary good response. When histologically characterized by highly anaplastic features, it seems the biologic behavior of this tumor remains uncertain. The aggressive behavior and the responsiveness to chemotherapy in this case may challenge the belief in the benign nature of these rare tumors.
Leukemia | 2000
S. Van Gool; E Van Kerschaver; Penelope Brock; H. Pottel; F. Hulstaert; Eugeen Vanmechelen; Anne Uyttebroeck; A Van De Voorde; Hugo Vanderstichele
Children acquire neuropsychologic dysfunctions after chemotherapy for hematologic malignancy. In this study, putative changes in levels of CSF-tau (a marker of neural dysintegrity) in leukemic children prior to and during chemotherapy were studied. Cerebrospinal fluid (CSF) samples were obtained before and during treatment from patients with B cell non-Hodgkins lymphoma (NHL, n = 10), non-B cell acute lymphoblastic leukemia/NHL (non-B-ALL, n = 48), acute myeloid leukemia (AML, n = 9), other malignant diseases (n = 9), and six control children. a sandwich-type elisa (innotest htau-ag) was used for measuring csf-tau. sixteen out of 50 patients with hematological malignancies, including the patients with proven leukemic cns invasion, already showed high csf-tau levels at baseline (>300 pg/ml). The pre-induction treatment for non-B-ALL, consisting of only corticosteroids and methotrexate (MTX), resulted in a significant increase of tau at day 8 (on average to 535 pg/ml). Larger increases as compared to baseline levels of CSF-tau were observed in patients treated for B-NHL with systemic vincristine, corticosteroids and cyclophosphamide, and intrathecal MTX (mean 776 pg/ml at day 8). In two AML patients with CNS invasion, CSF-tau increased during chemotherapy up to 1500 and 948 pg/ml, respectively. In one non-B-ALL patient with MTX-induced clinical neurotoxicity, CSF-tau was above the detection limit of 2000 pg/ml. Almost one-third of the patients with hematological malignancies had elevated CSF-tau levels at diagnosis. Transient high levels of CSF-tau, reaching levels observed in other neurodegenerative disorders, were observed during induction chemotherapy for non-B-ALL, B-NHL and CNS+ AML. The clinical implications of both observations will be the subject of further study.
The Journal of Pediatrics | 2013
Marie-Anne Morren; Anne Hoppe; Marleen Renard; Maria Debiec–Rychter; Anne Uyttebroeck; Patrice Dubreuil; Ludovic Martin
Diffuse cutaneous mastocytosis is a less common but potentially life-threatening variant of childhood mastocytosis. Here we report 2 children with diffuse cutaneous mastocytosis in whom an activating somatic KIT mutation was detected. Treatment with imatinib, a KIT inhibitor, resulted in resolution of the lesions and were well tolerated by the patients.
Cancer Genetics and Cytogenetics | 1995
Anne Uyttebroeck; Penelope Brock; Bert De Groote; Marleen Renard; Paola Dal Cin; Herman Van den Berghe; Maria Casteels-Van Daele
A boy aged 8 years, 10 months presented with refractory anemia. Bone marrow investigation revealed monolobular megakaryocytes. Cytogenetic analysis showed a clonal abnormality: 46, XY, del(5)(q14q32). This is the youngest individual ever reported with this disorder. A year after diagnosis, while on treatment with human recombinant erythropoietin, the bone marrow showed an excess of blasts. No bone marrow donor could be found. Transformation to acute myelomonocytic leukemia occurred 3 months later. In spite of intensive chemotherapy, the child died of progressive disease with massive splenomegaly and jaundice. The case illustrates that the 5q- syndrome can occur de novo in children. The outcome in this child was poor, which may reflect a difference from the adult 5q- syndrome or may possibly be related to the erythropoietin the child received.
European Journal of Nuclear Medicine and Molecular Imaging | 2007
Lieselot Brepoels; S Stroobants; W. De Wever; Karoline Spaepen; Peter Vandenberghe; José Thomas; Anne Uyttebroeck; Luc Mortelmans; Chris Peeters; Gregor Verhoef
Circulation, supplement | 2004
Javier Ganame; Anne Uyttebroeck; Marleen Renard; Jan D'hooge; Piet Claus; Bart Bijnens; Marc Gewillig; G.R Sutherland; Luc Mertens
Blood | 2004
Jan Cools; Lucienne Michaux; Carlos Graux; C Melotte; Hilmar Quentmeier; Adolfo A. Ferrando; Robert A. Levine; Vermeesch; M. Stul; B Dutta; Nancy Boeckx; André Bosly; Pierre Heimann; Anne Uyttebroeck; Nicole Mentens; R. Somers; Raf MacLeod; Hans G. Drexler; At Look; D G Gilliland; Peter Vandenberghe; W Wlodarska; Peter Marynen; Anne Hagemeijer
HemaSphere | 2018
Jolien De Bie; Sofie Demeyer; Olga Gielen; Heidi Segers; Lucienne Michaux; Peter Vandenberghe; Nancy Boeckx; Anne Uyttebroeck; Jan Cools
Archive | 2017
Charlotte Sleurs; Jurgen Lemiere; Daan Christiaens; Thibo Billiet; Marjolein Verly; Ronald Peeters; Stefan Sunaert; Anne Uyttebroeck; Sabine Deprez