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Dive into the research topics where Anne Vik is active.

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Featured researches published by Anne Vik.


Acta Neurologica Scandinavica | 2010

Overall survival, prognostic factors, and repeated surgery in a consecutive series of 516 patients with glioblastoma multiforme

R. Helseth; Eirik Helseth; Tom Børge Johannesen; C. W. Langberg; Knut Lote; Pål Rønning; David Scheie; Anne Vik; Torstein R. Meling

Helseth R, Helseth E, Johannesen TB, Langberg CW, Lote K, Rønning P, Scheie D, Vik A, Meling TR. Overall survival, prognostic factors, and repeated surgery in a consecutive series of 516 patients with glioblastoma multiforme. 
Acta Neurol Scand: 122: 159–167.
© 2010 The Authors Journal compilation


Acta Anaesthesiologica Scandinavica | 2007

Severe head injury: control of physiological variables, organ failure and complications in the intensive care unit.

Kari Schirmer-Mikalsen; Anne Vik; Sven Erik Gisvold; Toril Skandsen; H. Hynne; Pål Klepstad

Background:  In patients with severe head injury, control of physiological variables is important to avoid intracranial hypertension and secondary injury to the brain. The aims of this retrospective study were to evaluate deviations of physiological variables and the incidence of extracranial complications in patients with severe head injury. We also studied if these deviations could be related to outcome.


Stroke | 2009

Risk factors for aneurysmal subarachnoid hemorrhage in a prospective population study: the HUNT study in Norway.

Marie Søfteland Sandvei; Pål Romundstad; Tomm Brostrup Müller; Lars J. Vatten; Anne Vik

Background and Purpose— The morbidity and mortality of subarachnoid hemorrhage (SAH) are high, and established risk factors are scarce. We prospectively assessed the association of blood pressure, smoking, and body mass with the risk of aneurysmal SAH. Methods— All residents ≥20 years were invited to the Nord-Trøndelag Health (HUNT) Study (1984 to 1986) and 74 977 (88.1%) attended. The study included standardized measurements of blood pressure, body weight and height, and self-administered questionnaires. Participants who later had aneurysmal SAH (n=132) were identified, and hazard ratios (HRs), adjusted for age and sex, were estimated using Cox regression analysis. Results— The crude annual incidence of aneurysmal SAH was 9.9 per 100 000 people; the incidence was almost twice as high in women as in men (12.9 versus 6.8, P=0.001). Systolic blood pressure was positively associated with risk (P for trend=0.001). Compared with the reference (<130 mm Hg), the adjusted HR in people with systolic blood pressure of 130 to 139 mm Hg was 2.3 (95% CI, 1.4 to 3.8) and for systolic blood pressure >170 mm Hg, the HR was 3.3 (95% CI, 1.7 to 6.3). Diastolic pressure showed similar positive associations. Compared with never smokers, former (HR, 2.7; 95% CI, 1.4 to 5.1) and current (HR, 6.1; 95% CI, 3.6 to 10.4) smokers had substantially higher risk. Compared with normal weight (body mass index, 18.5 to 24.9 kg/m2), overweight people were at lower risk (HR, 0.6; 95% CI, 0.4 to 1.0). Conclusions— Systolic and diastolic blood pressure were strong predictors of aneurysmal SAH, and there was a substantially increased risk associated with smoking. However, high body mass was associated with reduced risk of aneurysmal SAH.


Journal of Neurology, Neurosurgery, and Psychiatry | 2012

A longitudinal MRI study of traumatic axonal injury in patients with moderate and severe traumatic brain injury

Kent Gøran Moen; Toril Skandsen; Mari Folvik; Veronika Brezova; Kjell Arne Kvistad; Jana Rydland; Geoffrey T. Manley; Anne Vik

Objective To study the evolution of traumatic axonal injury (TAI) detected by structural MRI in patients with moderate and severe traumatic brain injury (TBI) during the first year and relate findings to outcome. Methods 58 patients with TBI (Glasgow Coma Scale score 3–13) were examined with MRI at a median of 7 days, 3 months and 12 months post injury. TAI lesions were evaluated blinded and categorised into three stages based on location: hemispheres, corpus callosum and brainstem. Lesions in T2* weighted gradient echo (GRE), fluid attenuated inversion recovery (FLAIR) and diffusion weighted imaging (DWI) were counted and FLAIR lesion volumes were estimated. Inter-rater reliability score was calculated. Outcome was assessed 12 months post injury using the Glasgow Outcome Scale Extended. Results In the initial MRI, 31% had brainstem lesions compared with 17% at 3 months (p=0.008). In the FLAIR sequences, number and volumes of lesions were reduced from early to 3 months (p<0.001). In T2*GRE sequences, the number of lesions persisted at 3 months but was reduced at 12 months (p=0.007). The number of lesions in DWI and volume of FLAIR lesions on early MRI predicted worse clinical outcome in adjusted analyses (p<0.05). Conclusion This is the first study to demonstrate and quantify attenuation of non-haemorrhagic TAI lesions on structural MRI during the first 3 months after TBI; most importantly, the disappearance of brainstem lesions. Haemorrhagic TAI lesions attenuate first after 3 months. Only early MRI findings predicted clinical outcome after adjustment for other prognostic factors. Hence valuable clinical information may be missed if MRI is performed too late after TBI.


Journal of Neurotrauma | 2011

Prognostic Value of Magnetic Resonance Imaging in Moderate and Severe Head Injury: A Prospective Study of Early MRI Findings and One-Year Outcome

Toril Skandsen; Kjell Arne Kvistad; Ole Solheim; Stian Lydersen; Ingrid Haavde Strand; Anne Vik

The clinical benefit of early magnetic resonance imaging (MRI) in severe and moderate head injury is unclear. We sought to explore the prognostic value of the depth of lesions depicted with early MRI, and also to describe the prevalence and impact of traumatic brainstem lesions. In a cohort of 159 consecutive patients with moderate to severe head injury (age 5-65 years and surviving the acute phase) admitted to a regional level 1 trauma center, 106 (67%) were examined with MRI within 4 weeks post-injury. Depth of lesions in MRI was categorized as: hemisphere level, central level, and brainstem injury (BSI). The outcome measure was Glasgow Outcome Scale Extended (GOSE) 12 months post-injury. Forty-six percent of patients with severe injuries and 14% of patients with moderate injuries had BSI. In severe head injury, central or brainstem lesions in MRI, together with higher Rotterdam CT score, pupillary dilation, and secondary adverse events were significantly associated with a worse outcome in age-adjusted analyses. Bilateral BSI was strongly associated with a poor outcome in severe injury, with positive and negative predictive values of 0.86 and 0.88, respectively. In moderate injury, only age was significantly associated with outcome in multivariable analyses. Limitations of the current study include lack of blinded outcome evaluations and insufficient statistical power to assess the added prognostic value of MRI when combined with clinical information. We conclude that in patients with severe head injury surviving the acute phase, depth of lesion on the MRI was associated with outcome, and in particular, bilateral brainstem injury was strongly associated with poor outcomes. In moderate head injury, surprisingly, there was no association between MRI findings and outcome when using the GOSE score as outcome measure.


Archives of Physical Medicine and Rehabilitation | 2010

Cognitive Impairment 3 Months After Moderate and Severe Traumatic Brain Injury: A Prospective Follow-Up Study

Toril Skandsen; Torun Gangaune Finnanger; Stein Andersson; Stian Lydersen; Jan Ferenc Brunner; Anne Vik

OBJECTIVE To explore the magnitude and frequency of cognitive impairment 3 months after moderate to severe traumatic brain injury (TBI), and to evaluate its relationship to disability at 1-year follow-up. DESIGN Prospective follow-up study. SETTING Regional level I trauma center. PARTICIPANTS Patients aged 15 to 65 years with definite TBI, defined as Glasgow Coma Scale score of 3 to 13 and injury documented by magnetic resonance imaging (n=59) or computed tomography (n=2); healthy volunteers (n=47) served as controls. INTERVENTIONS Not applicable. MAIN OUTCOME MEASURES Neuropsychological assessment 3 months postinjury and Glasgow Outcome Scale Extended (GOSE) at 3 and 12 months postinjury. RESULTS Patients with TBI performed worse than controls, most consistently in terms of information processing speed and verbal memory. However, a maximum of only 43% of patients with TBI had impaired test scores (defined as <1.5 SD below mean of normative data) on any one measure. Based on a selection of 9 tests, a 0 or 1 impaired score was seen in 46 (98%) of 47 controls, in 20 (57%) of 35 patients with moderate TBI, and in 9 (35%) of 26 patients with severe TBI. At 1 year postinjury, disability (defined as GOSE score ≤6) was present in 57% of those with 2 or more impaired test scores and in 21% of those with 0 or 1 impaired score (P=.005). CONCLUSIONS In this sample of patients with recent, definite TBI and healthy volunteers, we found that TBI affected cognition in moderate as well as severe cases. The presence of cognitive impairment was associated with future disability. However, half of the patients with moderate TBI and even one third of those with severe TBI had a normal cognitive assessment 3 months postinjury.


Brain Injury | 2013

Differentiated patterns of cognitive impairment 12 months after severe and moderate traumatic brain injury

Torun Gangaune Finnanger; Toril Skandsen; Stein Andersson; Stian Lydersen; Anne Vik; Marit S. Indredavik

Abstract Objective: To assess cognitive function at 12 months after moderate and severe traumatic brain injury (TBI) separately, as well as improvement from 3 to 12 months and relationship to global outcome. Methods: Cognitive function among patients with moderate (n = 30, Glasgow Coma Scale score (GCS) 9–3) and severe traumatic brain injury (n = 20, GCS score ≤ 8), recruited from an unselected neurosurgical cohort, all with MRI performed in the early phase were assessed with a neuropsychological test battery and Glasgow Outcome Scale Extended. Healthy volunteers (n = 47) matched for age, gender and years of education served as controls. Results: Executive function was reduced at 12-months post-injury in patients with both moderate and severe TBI. However, motor function, processing speed and memory were reduced only among patients with severe TBI. Both patients with moderate and severe TBI improved their processing speed and visual memory. Patients with moderate TBI also improved motor function, while patients with severe TBI also improved executive function. Conclusion: Differentiating between patients with moderate and severe TBI yields a more accurate description of cognitive deficits and their improvement over time. Further, executive dysfunction and attention problems affected the ability to resume independent living and employment regardless of injury severity and age.


NeuroImage: Clinical | 2014

Prospective longitudinal MRI study of brain volumes and diffusion changes during the first year after moderate to severe traumatic brain injury

Veronika Brezova; Kent Gøran Moen; Toril Skandsen; Anne Vik; James B. Brewer; Øyvind Salvesen; Asta Håberg

The objectives of this prospective study in 62 moderate–severe TBI patients were to investigate volume change in cortical gray matter (GM), hippocampus, lenticular nucleus, lobar white matter (WM), brainstem and ventricles using a within subject design and repeated MRI in the early phase (1–26 days) and 3 and 12 months postinjury and to assess changes in GM apparent diffusion coefficient (ADC) in normal appearing tissue in the cortex, hippocampus and brainstem. The impact of Glasgow Coma Scale (GCS) score at admission, duration of post-traumatic amnesia (PTA), and diffusion axonal injury (DAI) grade on brain volumes and ADC values over time was assessed. Lastly, we determined if MRI-derived brain volumes from the 3-month scans provided additional, significant predictive value to 12-month outcome classified with the Glasgow Outcome Scale—Extended after adjusting for GCS, PTA and age. Cortical GM loss was rapid, largely finished by 3 months, but the volume reduction was unrelated to GCS score, PTA, or presence of DAI. However, cortical GM volume at 3 months was a significant independent predictor of 12-month outcome. Volume loss in the hippocampus and lenticular nucleus was protracted and statistically significant first at 12 months. Slopes of volume reduction over time for the cortical and subcortical GGM were significantly different. Hippocampal volume loss was most pronounced and rapid in individuals with PTA > 2 weeks. The 3-month volumes of the hippocampus and lentiform nucleus were the best independent predictors of 12-month outcome after adjusting for GCS, PTA and age. In the brainstem, volume loss was significant at both 3 and 12 months. Brainstem volume reduction was associated with lower GCS score and the presence of DAI. Lobar WM volume was significantly decreased first after 12 months. Surprisingly DAI grade had no impact on lobar WM volume. Ventricular dilation developed predominantly during the first 3 months, and was strongly associated with volume changes in the brainstem and cortical GM, but not lobar WM volume. Higher ADC values were detected in the cortex in individuals with severe TBI, DAI and PTA > 2 weeks, from 3 months. There were no associations between ADC values and brain volumes, and ADC values did not predict outcome.


Acta Anaesthesiologica Scandinavica | 2013

Intensive care and traumatic brain injury after the introduction of a treatment protocol: a prospective study

Kari Schirmer-Mikalsen; Kent Gøran Moen; Toril Skandsen; Anne Vik; Pål Klepstad

Traumatic brain injury (TBI) treatment protocols have been introduced in the intensive care unit (ICU) to avoid secondary brain injury. In this study, we aimed to evaluate the deviations from such a treatment protocol and the frequency of extracranial complications, and relate these findings to outcome.


Stroke | 2012

Joint Effect of Modifiable Risk Factors on the Risk of Aneurysmal Subarachnoid Hemorrhage: A Cohort Study

Haakon Lindekleiv; Marie Søfteland Sandvei; Pål Romundstad; Tom Wilsgaard; Inger Njølstad; Tor Ingebrigtsen; Anne Vik; Ellisiv B. Mathiesen

Background and Purpose— The joint effect of risk factors on the risk of aneurysmal SAH (aSAH) has been studied sparsely. Methods— We examined the potential synergism between cigarette smoking, hypertension, and regular alcohol consumption and the risk of aSAH in a prospective, population-based cohort of participants from the Nord-Trøndelag Health Study and the Tromsø Study in Norway. Interaction was assessed on additive and multiplicative scales. Results— We identified 122 cases of aSAH over 977 895 person-years of follow-up. Interaction was observed between current smoking and hypertension on the additive scale, (relative excess risk because of interaction, 6.40; 95% CI, 0.88–11.92, adjusted for sex and age). We found no significant interaction between hypertension and regular alcohol consumption or current cigarette smoking and regular alcohol consumption on the additive scale. No significant interaction was detected on the multiplicative scale. Conclusions— The joint effect of current smoking and hypertension on the risk of aSAH was stronger than was the sum of the independent effects of each factor. Persons at risk of aSAH should be advised of a markedly stronger risk for aSAH with the combination of current smoking and hypertension. In addition, the finding suggests that combining smoking cessation and blood pressure lowering may have an extra risk reduction effect on preventing aSAH.

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Toril Skandsen

Norwegian University of Science and Technology

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Kent Gøran Moen

Norwegian University of Science and Technology

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Asta Håberg

Norwegian University of Science and Technology

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Kari Schirmer-Mikalsen

Norwegian University of Science and Technology

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Kari Anne I. Evensen

Norwegian University of Science and Technology

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Marie Søfteland Sandvei

Norwegian University of Science and Technology

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Torun Gangaune Finnanger

Norwegian University of Science and Technology

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Alexander Olsen

Norwegian University of Science and Technology

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Kjell Arne Kvistad

Norwegian University of Science and Technology

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Ole Solheim

Norwegian University of Science and Technology

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